4-Hydroxy-6-fluoroquinoline

4-Hydroxy-6-fluoroquinoline, an organic compound, has unique chemical properties. In its molecular structure, the quinoline ring is the core, and the 6-position fluorine atom and the 4-position hydroxyl group give the substance different characteristics.
Let's talk about the physical properties first. At room temperature, 4-hydroxy-6-fluoroquinoline is often in a solid state, but the specific melting point and boiling point will vary depending on the purity. In terms of solubility, because it contains polar hydroxyl groups, it may have a certain solubility in polar solvents such as alcohols and ketones, but in non-polar solvents such as alkanes, the solubility may be low.
Let's talk about the chemical properties again. The 4-position hydroxyl group has high activity and can participate in many chemical reactions. One is the acid-base reaction. Hydroxyhydrogen has a certain acidity. When it encounters a strong base, it is easy to be deprived of protons and form corresponding salts. Second, the hydroxyl group can undergo a substitution reaction. For example, under basic conditions with halogenated hydrocarbons, the oxygen atom in the hydroxyl group attacks the halogen atom in the halogenated hydrocarbon to connect the carbon atom, and the halogen atom leaves to form ether compounds.
6 fluorine atoms also affect the chemical properties of 4-hydroxy-6-fluoroquinoline. Fluorine atoms are highly electronegative and have a strong electron-absorbing induction effect, which decreases the electron cloud density of the quinoline ring, resulting in changes in the activity of electrophilic substitution reactions on the ring. Compared with fluoroquinoline, electrophilic substitution reactions are more difficult to occur. However, the presence of fluorine atoms can enhance molecular stability and biological activity, which is of great significance in the field of medicinal chemistry.
In addition, the 4-hydroxy-6-fluoroquinoline quinoline ring can undergo reduction reaction. Under the action of suitable reducing agents, the double bonds on the ring can be partially or completely reduced to form different reduced products. Due to structural changes, the properties and reactivity of these products are also different from the original compound. In organic synthesis, it is often used as a key intermediate, and complex organic molecular structures are constructed through various reactions.

4-Hydroxy-6-fluoroquinoline is one of the unique properties of organic compounds. It has a wide range of uses and is often a key intermediate in the creation of antibacterial drugs. Geinquinoline compounds often have antibacterial activity. This 4-hydroxy-6-fluoroquinoline has a unique structure and can be chemically modified to enhance the antibacterial effect and inhibit the growth of pathogens. It is of great significance in the development of anti-infective drugs.
In the field of pesticides, it is also an important raw material. It can be derived from pesticides with efficient pest control functions. By precisely designing the molecular structure, the prepared pesticide can specifically act on the specific physiological target of pests, or interfere with their nervous system, or destroy their metabolic process, so as to achieve the purpose of efficient pesticide killing and ensuring the safe growth of agricultural crops.
Furthermore, it has also emerged in the field of materials science. Because its structure contains special functional groups, it can be used to prepare materials with special optical and electrical properties. For example, it can participate in the preparation of organic optoelectronic materials, which have potential applications in devices such as Light Emitting Diode and solar cells, providing new opportunities for the development of material innovation.
In addition, in the field of scientific research, it is often used as a model compound for chemical synthesis research. Chemists deepen their understanding of the basic principles of organic chemistry by exploring their reaction mechanisms and structural changes, providing theoretical and practical support for the development of new synthetic methods and the construction of complex organic molecules, and promoting the continuous progress of organic chemistry.

The synthesis method of 4-hydroxy-6-fluoroquinoline has been known for a long time, and is described in detail below.
First, suitable aromatic amines and halogenated aromatic hydrocarbons containing fluorine are used as starting materials. In a suitable reaction vessel, aromatic amines and halogenated aromatic hydrocarbons containing fluoride are added, supplemented by specific bases and catalysts. The bases can be potassium carbonate, sodium carbonate, etc. to adjust the acid-base environment of the reaction; the catalysts are often copper catalysts, such as cuprous iodide, which can accelerate the reaction process. The mixture is placed in a heating device and heated at a certain temperature (e.g. 120-150 ° C). After several hours (about 6-10 hours), the molecules interact and the nucleophilic substitution steps are taken to gradually build the skeleton of quinoline. After the reaction is completed, 4-hydroxy-6-fluoroquinoline can be obtained after cooling, extraction, column chromatography and other post-treatment operations.
Second, fluorinated phenolic compounds and enamines can also be used as raw materials. In the reaction system, phenols and enamines are added, and an appropriate amount of acid catalyst, such as p-toluenesulfonic acid, is added. Under mild heating conditions (about 80-100 ℃), the phenolic hydroxyl group and the enamine double bond undergo an addition reaction, and then it is cyclized within the molecule to form a quinoline structure. After the reaction, the product can be purified by conventional separation methods, such as distillation, recrystallization, etc., and the target 4-hydroxy-6-fluoroquinoline can also be obtained.
Third, fluorine-containing aldehyde and aminophenol derivatives can also be used as starting materials. In a solvent, the aldehyde is mixed with aminophenol derivatives, and a suitable condensing agent, such as polyphosphoric acid, is added. At an appropriate temperature (such as 100-130 ° C), the two first undergo a condensation reaction, and then cyclize to form 4-hydroxy-6-fluoroquinoline. After the reaction is completed, it is separated and purified to remove impurities and finally obtain a pure product.
The above synthesis methods have their own advantages and disadvantages. It is necessary to choose the good one according to the actual situation, such as the availability of raw materials, cost, yield and other factors.

I don't know what the market price of 4-hydroxy-6-fluoroquinoline is. The price of various chemicals on the market often changes due to various reasons, such as the trend of supply and demand, the difficulty of preparation, the difference in quality, the amount of purchase, and even the change of market conditions, the distance of origin, etc., can all affect its price.
If in the era of "Tiangong Kaiwu", there was no such fine chemical. At that time, the technology of chemistry was not as refined as it is today, and these compounds had not been synthesized, and there was no easy market price to test.
If you want to know the market price of 4-hydroxy-6-fluoroquinoline at this time, you can consult the chemical raw material trading platform and chemical reagent supplier for details, or you can contact the merchant specializing in this industry and ask for the price of different specifications and different purity products. Because of its unpredictable market dynamics, the real-time price can only be known by asking the industry.

For 4-hydroxy-6-fluoroquinoline, many matters should be paid attention to during storage and transportation.
Its nature may be more active, and the temperature and humidity of the environment should be the first priority during storage. It should be placed in a cool and dry place to prevent moisture decomposition and deterioration. If the humidity is too high, it may cause it to absorb water vapor, which will affect the purity and quality; if the temperature is not suitable, it may cause chemical reactions to occur, and if it is too low, it may cause changes in the physical state, which is not conducive to its preservation.
Furthermore, this substance is sensitive to light, so it should be avoided in a dark place to prevent light from causing decomposition or other photochemical reactions, which will damage its inherent properties.
As for the transportation process, the packaging must be sturdy and well sealed. First, to prevent leakage, if it leaks outside, it will not only waste, but also cause harm to the surrounding environment and people and animals; second, to ensure that it will not be damaged during transportation bumps. The environment of the means of transportation should also be controlled to maintain appropriate temperature and humidity, and avoid mixing with other substances that may react to prevent dangerous chemical reactions and endanger transportation safety.
When handling, operators should also be careful, follow established operating procedures, and wear appropriate protective equipment to prevent contact with this object and harm themselves. In this way, 4-hydroxy-6-fluoroquinoline must be properly stored and transported to ensure its quality and safety.