4-Hydroxy-6-bromoquinoline-3-carboxylicacid

4-Hydroxy-6-bromoquinoline-3-carboxylic acid is one of the organic compounds. It has a wide range of uses and is often a key intermediate in the creation of new drugs in the field of medicinal chemistry. The structure of geinoquinoline is common in many bioactive molecules. The special structure of this compound may endow drugs with unique biological activities, such as antibacterial, anti-inflammatory, and anti-tumor equivalent properties.
In the field of materials science, it also has potential uses. Or it can be chemically modified to introduce specific functional groups to prepare materials with special optical and electrical properties, such as organic Light Emitting Diode materials, sensor materials, etc. Due to the bromine atoms and hydroxyl groups in its structure, it can participate in a variety of chemical reactions, providing an opportunity for the regulation of material properties.
In addition, in the field of organic synthetic chemistry, this compound can be used as a starting material for the synthesis of more complex organic molecules. With the reactivity of its specific functional groups, novel carbon-carbon bonds and carbon-heteroatom bonds can be constructed by means of various organic reactions, such as nucleophilic substitution, redox, etc., thereby expanding the structural diversity of organic compounds and contributing to the development of organic synthetic chemistry.

4-Hydroxy-6-bromoquinoline-3-carboxylic acid, this is an organic compound. Its physical properties are unique, let me tell them one by one.
Looking at its appearance, it is often a solid powder like white to light yellow, fine and uniform. This substance is quite stable under normal temperature and pressure, and it is potentially dangerous in case of hot topics or open flames.
When it comes to melting point, it is about a specific temperature range, and its exact value varies slightly according to the preparation process and purity. The determination of melting point is one of the important indicators to distinguish the purity of this compound.
In terms of solubility, it shows different in common organic solvents. In some polar organic solvents, such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), it exhibits good solubility and can be uniformly dispersed to form a clear solution. However, in non-polar organic solvents, such as n-hexane, toluene, etc., the solubility is poor, and it is mostly suspended or precipitated. In water, its solubility is also limited. Although the hydroxyl group in the molecular structure can form hydrogen bonds with water, the existence of quinoline ring and bromine atom limits its solubility in water.
In addition, its density is also an important physical property. Although the exact value needs to be determined by professional instruments, the approximate range can be inferred according to its molecular structure and similar compounds.
The physical properties of this compound are crucial in the fields of organic synthesis and drug development. Knowing its appearance, melting point, solubility and density, etc., can rationally design the reaction conditions, optimize the synthesis path, and lay the foundation for its application in various fields.

The synthesis method of 4-hydroxy-6-bromoquinoline-3-carboxylic acid is described in detail below.
First take an appropriate amount of quinoline as the starting material, which is the foundation of the synthesis. Place it in a suitable reaction vessel, which should be clean and dry to prevent impurities from interfering with the reaction. Then, under specific reaction conditions, add a brominating reagent. The choice of this brominating reagent is crucial, and it should be carefully selected according to the specific requirements and conditions of the reaction. Generally speaking, liquid bromine or N-bromosuccinimide (NBS) are commonly used brominating reagents. When adding brominating reagents, pay attention to the reaction temperature, reaction time and the proportion of reactants. Too high or too low temperature can affect the process of bromination reaction and the selectivity of the product. After this bromination reaction, 6-bromoquinoline derivatives can be obtained.
Then, the obtained 6-bromoquinoline derivatives are hydroxylated. This step is also extremely important and involves the introduction of hydroxyl groups into the target product. Suitable hydroxylating reagents, such as aqueous solutions of alkali metal hydroxides, can be used to react at appropriate temperatures and reaction times. During the reaction, it is necessary to closely monitor the changes in the reaction system, such as color and precipitation formation, to determine the progress of the reaction.
Finally, carboxylation of the resulting product is carried out. This process can use carbon dioxide as a carboxylation reagent, and in the presence of organometallic catalysts, under specific reaction conditions. There are many types of organometallic catalysts, and those with high activity and selectivity for the reaction need to be selected. At the same time, the pressure, temperature and other conditions of the reaction need to be strictly controlled, so as to promote the smooth introduction of carboxyl groups to obtain 4-hydroxy-6-bromoquinoline-3-carboxylic acid.
During the synthesis process, after each step of the reaction, the product needs to be separated and purified. Common separation and purification methods such as column chromatography and recrystallization can be used to obtain high-purity products to ensure the success of the synthesis and the quality of the products.

4-Hydroxy-6-bromoquinoline-3-carboxylic acid, the price of this product in the market is difficult to determine. The price often changes due to various reasons.
Looking at the market of chemical raw materials in the past, the change in their price is related to the trend of supply and demand. If there are many people in the market, but the supply is small, the price will rise; conversely, if the supply exceeds the demand, the price may decline.
The difficulty of its preparation is also the main reason. The preparation of 4-hydroxy-6-bromoquinoline-3-carboxylic acid involves complex steps, special raw materials and exquisite processes. If the preparation is difficult, the raw materials are rare, and the process is difficult, the cost will be high, and its price in the market will not be low.
Furthermore, changes in the current situation and policy regulations can affect its price. The current situation is turbulent, transportation is blocked, material flow is not smooth, and prices may fluctuate; policy regulations, such as environmental protection orders and industrial policies, can affect the cost and scale of production, and then make prices change.
Then I checked the ancient books such as "Tiangong Kaiwu" in the past, but I did not get the exact market value of this product. In today's chemical market, new products are stacked, and prices are also changing rapidly. In order to know the exact price, the more accurate market price can be obtained by consulting chemical material merchants, intermarket brokers, or referring to the detailed price information of chemical products.

4-Hydroxy-6-bromoquinoline-3-carboxylic acid is a very important organic compound, and many key precautions must be paid attention to during storage.
The first to bear the brunt are the temperature and humidity of the storage environment. This compound is quite sensitive to temperature and humidity, and should be stored in a cool and dry place. High temperature can easily cause its chemical instability or cause adverse reactions such as decomposition; and high humidity may cause it to become damp, which in turn affects its purity and quality. Therefore, it is appropriate to store it in an environment with a temperature of about 15-25 ° C and a relative humidity of 40% -60%.
Secondly, light can also affect it. 4-Hydroxy-6-bromoquinoline-3-carboxylic acid should be avoided from direct exposure to strong light, because light may cause it to undergo photochemical reactions, resulting in structural changes. Therefore, it should be stored in brown bottles or other dark containers to effectively block light and slow down possible reaction rates.
Furthermore, the material of the storage container should not be underestimated. Containers that are chemically stable and do not react with the compound must be selected. Such as glass containers, if the material is suitable, can provide good sealing and chemical inertness; however, some plastic containers, or because they contain additives that can interact with compounds, need to be carefully selected to prevent reactions between containers and compounds, resulting in product deterioration.
In addition, pay attention to the ventilation of the storage space. Good ventilation can avoid the accumulation of harmful gases, and at the same time maintain the fresh air in the storage environment, which helps to prevent compounds from being polluted by other gases in the environment. And the storage place should be kept away from fire sources, heat sources, and various strong oxidizing agents, reducing agents, etc. Because of its specific chemical activity, contact with these substances may cause violent reactions, endangering safety.
Finally, during storage, be sure to make clear identification and records, indicating in detail the name, specification, storage date and other key information of the compound, so that it can be effectively managed and tracked in the follow-up, to ensure that its status and characteristics can be accurately grasped during use, and to avoid improper use due to unclear information. In this way, 4-hydroxy-6-bromoquinoline-3-carboxylic acid can be properly stored to maintain its good quality and performance.