4 Chloro 8 Methoxy 2 Methylquinoline
quinoline thiophene imidazole thiazole

4-Chloro-8-methoxy-2-methylquinoline

Taiy Chemical

    Specifications

    HS Code

    153272

    Chemical Formula C11H10ClNO
    Molecular Weight 207.656 g/mol
    Solubility In Water Likely low as it is a relatively non - polar organic compound
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane etc. due to its organic nature
    Odor No information on odor without additional data

    As an accredited 4-Chloro-8-methoxy-2-methylquinoline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing
    Storage
    Shipping
    Free Quote

    Competitive 4-Chloro-8-methoxy-2-methylquinoline prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615365036030 or mail to info@alchemist-chem.com.

    We will respond to you as soon as possible.

    Tel: +8615365036030

    Email: info@alchemist-chem.com

    General Information
    Where to Buy 4-Chloro-8-methoxy-2-methylquinoline in China?
    As a trusted 4-Chloro-8-methoxy-2-methylquinoline manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Chloro-8-methoxy-2-methylquinoline supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 4-Chloro-8-methoxy-2-methylquinoline?
    4-Chloro-8-methoxy-2-methylquinoline is one of the organic compounds. Its physical properties are unique, let me tell them one by one.
    Looking at its appearance, under normal temperature and pressure, it is often in a solid state. The color of this compound, or white to light yellow powder, is like the light light under the autumn morning light, delicate and pure.
    The melting point has been determined by many researchers and is about a specific temperature range. The number of this melting point is crucial in many processes such as organic synthesis, separation and purification. Because the melting point is known, it is possible to know the temperature at which the compound can be converted from solid to liquid, which is convenient to control the transition of its physical state, and can accurately grasp the temperature during production and preparation.
    In other words, its solubility has a certain solubility in common organic solvents, such as ethanol and acetone. This property is crucial for the construction of organic reaction systems. Because organic reactions are mostly carried out in a solution environment, good solubility allows the reactants to be fully contacted, accelerating the reaction process and improving the reaction efficiency. If in water, its solubility is poor, which is also in line with the versatility of many organic compounds containing aromatic rings. The hydrophobicity of the aromatic ring structure makes it difficult for the compound to blend closely with water molecules.
    In addition, the density of 4-chloro-8-methoxy-2-methylquinoline is also an important physical parameter. Although the specific value needs to be accurately measured to know, the density of the compound has an impact on the separation and storage of substances. The difference in density can be used to separate the compound from other substances by physical methods. When storing, it is also necessary to choose a suitable container and storage method according to its density characteristics.
    As for its volatility, it is relatively weak. Due to its stable molecular structure and strong intermolecular forces, the compound is not easy to evaporate into gas at room temperature. This feature provides a certain guarantee for the safety of its storage and use. It is not easy to volatilize, which reduces the loss caused by volatilization and reduces the risk of forming harmful gases in the air.
    What are the chemical properties of 4-Chloro-8-methoxy-2-methylquinoline?
    4-Chloro-8-methoxy-2-methylquinoline, this is an organic compound. It has many unique chemical properties.
    Let's talk about its physical properties first, usually solid, white or yellowish in color, with specific melting points and boiling points. However, these values vary according to specific conditions.
    In terms of chemical activity, chlorine atoms give it active properties. Chlorine is an electron-absorbing group, which changes the electron cloud density of the benzene ring, making it more prone to nucleophilic substitution reactions. When there are nucleophiles, chlorine atoms are easily replaced, and various compounds are derived. It is of great significance in the field of drug synthesis. It can be used to introduce different functional groups and expand the functions of compounds.
    8-site methoxy group also has an effect on the distribution of molecular electron clouds. Methoxy group is a donator group, which can enhance the electron cloud density of the benzene ring and affect the check point and activity of the reaction in some reactions. It can stabilize the reaction intermediate and has a great influence on the reaction process and product selectivity involving the benzene ring. The presence of
    2-methyl group affects the molecular spatial structure and electronic effect. Methyl group is a donator group. Although it does not affect the degree of methoxy group, it can change the molecular polarity and steric resistance, affect the intermolecular force, and then affect its physical and chemical properties, such as solubility and melting point. And due to the steric resistance, the attack direction and reactivity of reagents will be affected in some reactions.
    Furthermore, the quinoline parent nucleus of this compound is aromatic, stable and participates in various reactions. The quinoline ring electron cloud distribution is unique, and electrophilic substitution reactions can occur. The reaction check point is affected by the localization effect of other substituents on the ring.
    In short, 4-chloro-8-methoxy-2-methylquinoline presents rich chemical properties due to the interaction of each substituent with the quinoline parent nucleus, providing a broad space for organic synthesis and drug development.
    What are the main uses of 4-Chloro-8-methoxy-2-methylquinoline?
    4-Chloro-8-methoxy-2-methylquinoline is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the synthesis of drugs in the field of medicinal chemistry. Due to its unique chemical activity, it can be combined with other compounds through many chemical reactions to construct complex molecular structures with specific pharmacological activities, which can help create new drugs, such as the development and preparation of antibacterial, anti-inflammatory, anti-tumor and other drugs. All rely on this compound as a starting material.
    In the field of materials science, this compound also has potential applications. Its molecular structure imparts specific optical and electrical properties, or can be used to prepare materials with special properties, such as organic Light Emitting Diode (OLED) materials, photoconductor materials, etc. Its unique structure can affect the electron transport and energy conversion efficiency of materials, providing possibilities for innovative development of materials science.
    Furthermore, in the field of organic synthetic chemistry, 4-chloro-8-methoxy-2-methylquinoline is also an important synthetic building block. Chemists can manipulate their functional groups to synthesize a series of organic compounds with diverse structures through various reactions such as substitution, addition, and cyclization, expanding the types and functions of organic compounds, and promoting the continuous progress of organic synthetic chemistry. It is of great significance in basic research and industrial production.
    What are 4-Chloro-8-methoxy-2-methylquinoline synthesis methods?
    The synthesis method of 4-chloro-8-methoxy-2-methylquinoline is an important topic in the field of organic synthesis. In the past, when exploring the synthesis of this compound, various strategies were tried.
    First, the quinoline parent nucleus was constructed by condensation reaction of aromatic amines and halogenated acetophenone. In an appropriate solvent, such as ethanol or toluene, an appropriate amount of base, such as potassium carbonate or sodium carbonate, was added, and heated to reflux, which promoted the nucleophilic substitution reaction of aromatic amines and halogenated acetophenone, and then cyclized to form a quinoline structure. Thereafter, chlorine atoms can be introduced at specific positions through selective halogenation reactions, such as N-chlorosuccinimide (NCS) as a chlorination reagent, and chlorine atoms can be introduced at the 4-position of the quinoline ring under suitable reaction conditions. As for the introduction of methoxy groups, the nucleophilic substitution reaction of the corresponding haloalkane and phenol salt can be used, and the reaction of dimethyl sulfate or iodomethane with the corresponding phenolic compound under basic conditions can be used to introduce methoxy groups at the 8-position. The presence of 2-methyl groups may be included at the time of starting material design, or may be introduced by subsequent methylation reactions, such as iodomethane and the corresponding quinoline derivatives, under base catalysis. < Br >
    Second, heterocyclic compounds are also used as the starting materials for conversion. For example, a suitable pyridine derivative is selected, and the quinoline structure is constructed through a series of substitution and cyclization reactions. The pyridine ring is modified first, and a suitable substituent is introduced, and then the quinoline ring is formed by the reaction of the intron ring. After that, 4-chloro, 8-methoxy and 2-methyl groups are introduced at the target position according to similar halogenation, methoxylation and methylation methods.
    Third, the microwave radiation synthesis method is also an effective way. This method can accelerate the reaction process, shorten the reaction time and improve the reaction yield. Using conventional starting materials, the reaction is carried out under specific power, time and temperature conditions in a microwave radiation device. During this process, the molecules are rapidly vibrated by microwave radiation, accelerating the collision frequency between the reaction molecules, thereby promoting the efficient synthesis of the reaction.
    All synthesis methods have their own advantages and disadvantages. According to the specific experimental conditions, the availability of raw materials and the purity requirements of the target product, an appropriate synthesis strategy should be carefully selected to achieve the purpose of efficient and high-quality synthesis of 4-chloro-8-methoxy-2-methylquinoline.
    4-Chloro-8-methoxy-2-methylquinoline What are the precautions in storage and transportation?
    4-Chloro-8-methoxy-2-methylquinoline is an organic compound. During storage and transportation, many things need to be paid attention to to to ensure its quality and safety.
    When storing, the first choice of environment. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. This compound is easily decomposed by heat, and the temperature is too high or close to the fire source, or it may cause danger. For example, if stored in a high temperature, unventilated place, the compound may deteriorate due to heat accumulation, or even cause combustion, explosion and other accidents.
    Humidity is also a key factor. Because it may react with water vapor, it is necessary to prevent moisture. It can be stored in a sealed container, such as a glass or plastic bottle, to ensure a good seal and prevent the intrusion of water vapor. If the seal is not good, water vapor seeps in, or the compound undergoes a reaction such as hydrolysis, which changes its chemical properties.
    In addition, the storage place should be kept away from oxidants and acids. 4-chloro-8-methoxy-2-methylquinoline or react violently with these substances. For example, contact with strong oxidants, or cause violent oxidation reactions, resulting in fire or explosion.
    When transporting, the packaging must be stable and tight. Choose suitable packaging materials to ensure that it will not be damaged and leaked due to vibration or collision during transportation. For example, it is necessary to use a strong outer packaging with a buffer material inside to prevent damage to the packaging during transportation bumps.
    Transportation vehicles are also required to be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. If a leak occurs during transportation, it can be responded to in time. And transportation personnel need to be professionally trained and familiar with the characteristics of the compound and emergency treatment methods. In case of leakage, know how to properly collect and deal with the leak to avoid environmental pollution and personal injury.
    Transportation route planning should not be ignored. Densed areas and environmentally sensitive areas should be avoided to prevent large-scale hazards caused by leakage. Therefore, during the storage and transportation of 4-chloro-8-methoxy-2-methylquinoline, attention should be paid to the above items to ensure its safety and avoid accidents.