4 Chloro 7 Fluoro 6 Methoxyquinoline 3 Carbonitrile
quinoline thiophene imidazole thiazole

4-chloro-7-fluoro-6-methoxyquinoline-3-carbonitrile

Taiy Chemical

    Specifications

    HS Code

    549840

    Chemical Formula C11H6ClFN2O
    Molecular Weight 238.63
    Appearance Solid (usually)
    Physical State At Room Temp Solid
    Odor Typically odorless or faint
    Melting Point Varies, specific data needed from literature
    Boiling Point Varies, specific data needed from literature
    Solubility In Water Low solubility
    Solubility In Organic Solvents Soluble in some organic solvents like dichloromethane, DMSO
    Density Data from experimental determination required
    Pka Data from experimental determination required
    Flash Point Data from experimental determination required

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    Frequently Asked Questions

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    What is the chemistry of 4-chloro-7-fluoro-6-methoxyquinoline-3-carbonitrile?
    4-Chloro-7-fluoro-6-methoxyquinoline-3-formonitrile, this is an organic compound. Looking at its structure, the quinoline ring is its core, and many substituents on it give it unique chemical properties.
    Let's talk about the chlorine atom first. It has electron-withdrawing properties, which can change the distribution of molecular electron clouds and affect the reactivity. In the nucleophilic substitution reaction, the chlorine atom can act as a leaving group. When there is a nucleophilic agent attack, it leaves to form a new compound.
    The fluorine atom also has a strong electron-withdrawing effect, and the atomic radius is small, which will enhance the molecular fat solubility and affect the biological activity and metabolic stability. In medicinal chemistry, fluorine-containing compounds often exhibit good pharmacological activity due to the unique properties of fluorine atoms.
    Methoxy group is the power supply group, which can increase the electron cloud density of the quinoline ring, which has an impact on the localization of electrophilic substitution reactions, or makes the reactions more likely to occur at specific locations.
    Cyanyl groups are active and can participate in a variety of reactions, such as hydrolysis to form carboxylic acids, reduction to amines, or addition to nucleophiles.
    This compound can be used as a key intermediate in the field of organic synthesis due to the interaction of these substituents to construct complex organic molecules through different reaction pathways. In drug development, due to its structural characteristics or potential biological activity, it can be used as a lead compound to further optimize the modification and develop new drugs. Due to its unique chemical properties, it has attracted much attention in chemistry and related fields, and is of great research and application value.
    What are 4-chloro-7-fluoro-6-methoxyquinoline-3-carbonitrile synthesis methods?
    The synthesis of 4-chloro-7-fluoro-6-methoxyquinoline-3-formonitrile is a subject of considerable interest in organic synthetic chemistry. Its synthesis path is often achieved by a multi-step reaction, and each step of the reaction is complementary to each other to achieve the target product.
    In the first step, a suitable starting material, such as an aromatic compound with a specific substituent, is often used to introduce a methoxy group through a nucleophilic substitution reaction. This step requires the selection of a suitable base and a reaction solvent to promote the smooth progress of the reaction. The strength of the base and the polarity of the solvent have a great influence on the reaction rate and yield. If the base is too strong, it may cause side reactions to breed; improper solvent polarity may also reduce the reactivity.
    The second step involves the introduction of chlorine atoms and fluorine atoms at appropriate positions. This process may involve halogenation, which can be achieved by halogenating reagents, such as compounds containing chlorine and fluorine, under specific reaction conditions. Reaction temperature, time, and the amount of halogenating reagent are all key factors. If the temperature is too high, or excessive halogenation is initiated; if the time is too short, the halogenation is incomplete.
    The last step is to construct a quinoline ring and introduce a cyanide group. This step often requires the use of cyclization and cyanidation reactions. The cyclization reaction can form a quinoline structure in the molecule by suitable catalysts and reaction conditions; the cyanidation reaction can introduce the cyanide group into the target position through the cyanide reagent. The activity of the catalyst and the stability of the cyanide reagent have a significant impact on the formation of the final product.
    When synthesizing 4-chloro-7-fluoro-6-methoxyquinoline-3-formonitrile, the precise control of each step of the reaction and the purification of the intermediate are all crucial. The optimization of the conditions of each step requires comprehensive consideration of various factors in order to improve the yield and purity of the target product and achieve the purpose of efficient synthesis.
    What are the main uses of 4-chloro-7-fluoro-6-methoxyquinoline-3-carbonitrile?
    4-Chloro-7-fluoro-6-methoxyquinoline-3-formonitrile is an important compound in the field of organic synthesis. It has a wide range of uses and has outstanding performance in many fields such as medicinal chemistry and materials science.
    In the field of medicinal chemistry, this compound is often used as a key intermediate. Due to its unique chemical structure, it can be reacted through a series of chemical reactions to build molecular structures with specific biological activities. For example, by modifying its substituents, targeted drugs for specific diseases can be developed. The occurrence and development of causative diseases involves many biochemical pathways, and compounds with specific structures can precisely act on key targets, thereby regulating biological processes and achieving the purpose of treating diseases. Therefore, 4-chloro-7-fluoro-6-methoxyquinoline-3-formonitrile is a cornerstone for the creation of new drugs, providing possibilities for pharmaceutical developers to explore new paths.
    In the field of materials science, this compound has also emerged. Due to its special optical or electrical properties, it can be used to prepare functional materials. For example, through rational design and synthesis, or materials with specific photoluminescence properties can be prepared, which can be used in optoelectronic devices such as organic Light Emitting Diode (OLED) to improve the luminous efficiency and stability of the device; or because of its electrical properties, it can be applied to the field of semiconductor materials, optimize the electrical properties of materials, and promote the development of miniaturization and high performance of electronic devices.
    In summary, 4-chloro-7-fluoro-6-methoxyquinoline-3-formonitrile is used in modern chemistry-related fields. With its unique structure, it has triggered a variety of uses and injected vitality into the innovation and development of various fields.
    What is the market outlook for 4-chloro-7-fluoro-6-methoxyquinoline-3-carbonitrile?
    4-Chloro-7-fluoro-6-methoxyquinoline-3-formonitrile is an important compound in the field of organic synthesis. Looking at its market prospects, it can be said to be quite broad.
    In the field of pharmaceutical research and development, this compound has a unique structure and may provide a key intermediate for the creation of new drugs. Geinquinoline compounds often exhibit a variety of biological activities, such as antibacterial, antiviral, and antitumor. The specific substituent of 4-chloro-7-fluoro-6-methoxyquinoline-3-formonitrile may endow it with unique pharmacological properties, which has attracted many pharmaceutical companies and scientific research institutions to compete for research. It is expected to give birth to novel therapeutic drugs to meet the needs of patients, which is also a potential opportunity in the pharmaceutical market.
    Furthermore, in the field of materials science, organic compounds are often the basis for the preparation of high-performance materials. The special structure of 4-chloro-7-fluoro-6-methoxyquinoline-3-formonitrile may give it unique optical and electrical properties. Therefore, it can be used to develop new photovoltaic materials, such as organic Light Emitting Diode (OLED), solar cell materials, etc. With the rapid development of science and technology, the demand for such materials is increasing day by day, and its market potential cannot be ignored.
    However, its market also faces challenges. Synthesis of this compound may require fine processes and specific raw materials, and the cost may be high. And in large-scale production, how to ensure the purity and stability of the product is also an urgent problem to be solved. In addition, the competition of similar compounds is also quite fierce. To gain a place in the market, it is necessary to continuously improve the technology and improve the product quality and competitiveness.
    To sum up, although the market prospect of 4-chloro-7-fluoro-6-methoxyquinoline-3-formonitrile is bright, it also needs to deal with many challenges. If the relevant problems can be properly solved, it will be able to shine in the market.
    Is the production process of 4-chloro-7-fluoro-6-methoxyquinoline-3-carbonitrile complicated?
    The production process of 4-chloro-7-fluoro-6-methoxyquinoline-3-formonitrile is not to proliferate. This compound is often used in the field of medicinal chemistry, and its synthesis can follow the conventional path of organic synthesis.
    Initially, suitable starting materials can be selected to construct the core structure of quinoline. Often based on compounds containing nitrogen and aromatic rings, quinoline is formed by various reactions, such as nucleophilic substitution, cyclization, etc.
    If you want to introduce a chlorine atom at the 4th position, or you can use a chlorinated reagent, such as a chlorine-containing halogen, under appropriate reaction conditions, perform an electrophilic substitution or nucleophilic substitution reaction, so that the chlorine atom falls precisely at the 4th position. The introduction of a fluorine atom at the 7th position also requires the selection of a suitable fluorine-containing reagent, which controls the reaction conditions according to the reactivity of the fluorine atom and the characteristics of the substrate, so that it is connected to the 7th position. The addition of the 6-position methoxy group can be made by means of a methoxylating reagent and a nucleophilic substitution method to make it connected to the 6th position. As for the generation of the 3-position nitrile group, this key nitrile functional group can be obtained by the cyanide-containing reagent through
    During the reaction process, temperature, reaction time, proportion of reactants and choice of solvent are all important. If the temperature is too high or too low, the reaction rate and selectivity can be different from expectations; the length of the reaction time also affects the purity and yield of the product; the proportion of reactants is improper, or side reactions may occur; and the nature of the solvent is related to the feasibility and rate of the reaction.
    After the reaction is completed, separation and purification techniques, such as column chromatography, recrystallization, etc. are required to remove impurities and obtain pure 4-chloro-7-fluoro-6-methoxyquinoline-3-formonitrile. Therefore, although the process of synthesis requires precise control of details, it is difficult to do it according to the principles and laws of organic synthesis.