4-Amino-2-bromoquinoline

4-Amino-2-bromoquinoline is one of the organic compounds. Its physical properties have the following characteristics.
First appearance, under normal conditions, it is often white to light yellow crystalline powder. The appearance of this color state is due to its molecular structure and light action. The powder form is easy to use and subsequent experimental operations and reactions.
When it comes to the melting point, it is about 198-202 ° C. The melting point is the critical temperature at which a substance changes from solid to liquid. In this temperature range, the force between the molecules of 4-amino-2-bromoquinoline changes, and the lattice structure disintegrates, thereby realizing the phase transition. This melting point characteristic is of great significance in the purification and identification of compounds.
As for solubility, it is slightly soluble in water. In water, polar solvents are also. Although the molecular structure of 4-amino-2-bromoquinoline contains amino groups, which can form hydrogen bonds with water, the presence of bromine atoms and quinoline rings changes the overall polarity of the molecule, so it is only slightly soluble in water. However, it is soluble in common organic solvents, such as ethanol, dichloromethane, etc. Ethanol has a certain polarity, and can interact with 4-amino-2-bromoquinoline molecules by hydrogen bonds and van der Waals forces; although dichloromethane has a weak polarity, the hydrophobic part of the quinoline ring is compatible with it, so it can be dissolved. This solubility difference can be well utilized in chemical operations such as separation and extraction.
In addition, 4-amino-2-bromoquinoline has a certain stability. Under normal temperature and pressure and general environmental conditions, it is not easy to spontaneous decomposition or other violent reactions. However, when it encounters special chemical reagents such as strong oxidizing agents, strong acids, and strong bases, its stability or destruction will trigger chemical reactions, which is also related to the activity of amino groups, bromine atoms, and quinoline rings in its molecular structure.
In summary, the physical properties of 4-amino-2-bromoquinoline, such as appearance, melting point, solubility, and stability, are determined by its unique molecular structure, and play an important role in many fields such as chemical research and drug synthesis, providing a basic basis for related operations and reactions.

4-Amino-2-bromoquinoline is an organic compound with unique chemical properties. In this compound, the bromine atom and the amino group are both key functional groups, giving it a variety of chemical activities.
Bromine atoms are active and can participate in nucleophilic substitution reactions. Due to the high electronegativity of bromine, the C-Br bond is polar, making bromine easily replaced by nucleophiles. For example, in the presence of appropriate bases and nucleophiles, bromine can be replaced by hydroxyl, alkoxy or amino groups to synthesize various quinoline derivatives, which is important for the construction of complex organic molecular structures.
Amino groups also have important chemical properties. Amino groups are alkaline and can react with acids to form salts. In organic synthesis, this property can be used to regulate the solubility and reactivity of compounds. In addition, amino groups can participate in electrophilic substitution reactions, because the lone pair electrons on the nitrogen atom can provide electron cloud density to the benzene ring or quinoline ring, making the benzene ring or quinoline ring more susceptible to electrophilic attack, thus introducing new functional groups to achieve structural modification and functionalization.
4 -Amino-2 -bromoquinoline has a wide range of uses in the field of organic synthesis due to the synergistic effect of bromine atoms and amino groups. It can be used as a key intermediate for the preparation of drugs, dyes and functional materials. Its unique chemical properties provide many possibilities for the research and application of organic synthetic chemistry.

4-Amino-2-bromoquinoline is a compound commonly involved in the field of organic synthesis. There are three common methods for its synthesis.
First, the method of using quinoline as the initial material. Under specific conditions, shilling quinoline is brominated with brominating reagents such as bromine and N-bromosuccinimide (NBS), and bromine atoms are introduced into the 2-position of the quinoline ring to obtain 2-bromoquinoline. Then, 2-bromoquinoline is reacted with ammonia sources, such as liquid ammonia, ammonia water, etc., under high temperature and pressure or with the help of catalysts, so that the bromine atom is replaced by the amino group, and the final 4-amino-2-bromoquinoline is obtained. The steps of this route are clear, but the reaction conditions of bromination and aminolysis may be more severe, which requires quite high equipment.
Second, the method of using aniline derivatives as starting materials. The aniline derivative is reacted with suitable brominating reagents to introduce bromine atoms at specific positions in the benzene ring. After cyclization, the quinoline ring structure is constructed. This cyclization reaction often requires suitable catalysts and specific reaction conditions, such as in acidic or alkaline environments, facilitated by heating or light conditions. After cyclization, the target product is obtained by conversion of appropriate functional groups. This method can flexibly adjust the structure of the starting material, facilitate the modification of the target molecule, and then the selectivity and yield of the cyclization reaction may need to be finely regulated.
Third, the coupling reaction method with the help of transition metal catalysis. First, quinoline derivatives containing bromine and active groups that can be coupled with amino groups are prepared, and then suitable transition metal catalysts, such as palladium and copper, are selected. Under the condition of ligand assistance, the coupling reaction occurs with the amino source. This method has the advantages of mild reaction conditions and good selectivity. However, the cost of catalysts and ligands may be higher, and the reaction system may be more complex, which also requires high reaction operation.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively weigh factors such as raw material availability, cost consideration, product purity requirements, etc., and choose the optimal method to prepare 4-amino-2-bromoquinoline.

4-Amino-2-bromoquinoline, an organic compound, is used in many fields.
In the field of medicinal chemistry, it is an important synthetic intermediate. Geinquinoline compounds have various biological activities, such as antibacterial, anti-inflammatory, and anti-tumor. 4-Amino-2-bromoquinoline can introduce different functional groups through specific chemical reactions to build complex drug molecules. For example, by reacting with specific amine compounds, it can generate new quinoline derivatives with potential anti-cancer activity, which act on specific targets of cancer cells and inhibit their proliferation.
In the field of materials science, it also has certain application potential. It can be used as a starting material for the synthesis of functional materials. Due to the existence of amino and bromine atoms, it can participate in polymerization reactions, etc., to form polymeric materials with unique optoelectronic properties. It may be applied to devices such as organic Light Emitting Diode (OLED) to endow materials with unique luminous properties and improve the luminous efficiency and stability of the device.
In the field of pesticide chemistry, it has also attracted much attention. Quinoline structures are common in some pesticides, and 4-amino-2-bromoquinoline may be modified to develop new pesticides. Or it has repellent or toxic effects on specific pests, providing a new way for agricultural pest control, and may be more selective and environmentally friendly than traditional pesticides.
In conclusion, although 4-amino-2-bromoquinoline is a small organic molecule, it has important application value in many fields such as medicine, materials, and pesticides. With the deepening of research, its potential application may become more extensive.

4 - Amino - 2 - bromoquinoline is an organic compound. Its market price is difficult to sum up, and it depends on various factors.
First, the difficulty of production has a great impact on its price. If the preparation of this compound requires cumbersome steps, special raw materials or harsh reaction conditions, the production cost will be high, and the price will also rise. For example, if the required raw materials are scarce and difficult to find, or the reaction requires precise control of temperature and pressure, and the equipment requirements are quite high, the cost will rise.
Second, the situation of market supply and demand is also key. If the demand for 4-Amino-2-bromoquinoline is strong at a certain time, but the supply is limited, such as the development of new drugs in the pharmaceutical field, there is a large demand for it, but the number of manufacturers is not large, or the production scale is limited, the price will rise due to the shortage of supply. On the contrary, if the supply exceeds the demand, the price will decline.
Third, the quality is also related to the price. High purity 4-Amino-2-bromoquinoline, because it is widely used in scientific research, high-end pharmaceutical production and other fields, the price is often higher than that of lower purity.
In addition, different suppliers offer different prices due to their different cost structures and business strategies. Large and technically mature suppliers may have an advantage in price due to economies of scale, while small suppliers, or due to high flexibility, may also have attractive prices under certain circumstances.
Therefore, to know the exact market price of 4 - Amino - 2 - bromoquinoline, it is necessary to check the market conditions in detail, compare the quotations of different suppliers, and consider the above factors to obtain more accurate price information.