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4-amino-1-isobutyl-1h-imidazo chemical structure of [4,5-c] quinoline
4-Amino-1-isobutyl-1H-imidazo [4,5-c] quinoline is an organic compound. According to its name, its structure contains an imidazolo-quinoline parent nucleus, which is fused by an imidazole ring and a quinoline ring. The two rings share adjacent carbon atoms to form a unique fused ring structure.
There is isobutyl at 1 position, and isobutyl is a branched chain alkyl group. Its structure is -CH ² CH (CH 🥰) -2, through which the carbon atom is connected to 1 position of the imidazolo-quinoline parent nucleus. The 4-position is connected with an amino group, that is, the -NH ² group, which is directly connected to the parent nucleus.
These compounds containing imidazolo-quinoline structures have attracted much attention in the field of medicinal chemistry due to their unique molecular structures. Imidazolo-quinoline skeletons can provide a variety of biological activities, such as some of these compounds may have anti-tumor, antiviral, antibacterial and other biological activities. The introduction of isobutyl and amino groups can change the physicochemical properties and biological activities of compounds. Isobutyl can enhance the lipid solubility of compounds, affect their transmembrane transport and distribution in vivo; amino groups can participate in the formation of hydrogen bonds and affect the interaction between compounds and biological targets.
What are the main uses of 4-amino-1-isobutyl-1h-imidazo [4,5-c] quinoline
4-Amino-1-isobutyl-1H-imidazo [4,5-c] quinoline, Chinese name or 4-amino-1-isobutyl-1H-imidazolo [4,5-c] quinoline. This substance is quite versatile and is often used as a key intermediate in the field of pharmaceutical research and development to create drugs with specific biological activities.
Looking at the path of medicinal chemistry, with the unique structure of such compounds, they can be chemically modified and modified to endow new molecules with the ability to target specific disease-related targets, such as tumor cell proliferation, inflammatory response pathways, etc., paving the way for the development of anti-tumor and anti-inflammatory drugs.
In the context of materials science, they can participate in the construction of functional materials due to their structural properties. For example, in the creation of optoelectronic device materials, their special electronic structure and optical properties may be used to fabricate materials that have specific responses to light and electrical signals, contributing to the improvement of optoelectronic device performance.
In terms of biochemistry research, because its structure fits with some biomacromolecules, it can be used as a probe molecule to help explore complex biochemical processes in organisms. By marking or specifically combining with biomolecules, insights into the interactions and metabolic pathways of biomolecules provide powerful tools for life science research.
In short, 4-amino-1-isobutyl-1H-imidazo [4,5-c] quinoline has potential application value in many fields such as medicine, materials, biology, etc. It is like an unpolished jade, waiting for researchers to explore it in depth and make it bloom.
What are the physical properties of 4-amino-1-isobutyl-1h-imidazo [4,5-c] quinoline
4-Amino-1-isobutyl-1H-imidazo [4,5-c] quinoline is an organic compound that has attracted much attention in the field of organic chemistry. The physical properties of this compound are quite important, and it is related to its performance in various chemical processes and practical applications.
Its properties are mostly crystalline solids, and its appearance is often white to light yellow. This color and morphology are derived from the arrangement of molecules and the characteristics of electronic transitions. Its melting point is between 180 and 190 ° C. This value is crucial, because the melting point not only reflects the strength of intermolecular forces, but also acts as a key indicator in the purification and identification process of compounds. Higher melting points suggest strong interactions between molecules, such as hydrogen bonds, van der Waals forces, etc., which make the molecules closely arranged and require more energy to destroy the lattice structure, and then melt into a liquid state.
The compound exhibits specific solubility in common organic solvents. It has good solubility in polar organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), because the polar solvent and the compound molecules can form hydrogen bonds or dipole-dipole interactions, which help the molecules to disperse in the solvent. However, in non-polar solvents such as n-hexane and toluene, the solubility is poor, because the interaction between non-polar solvents and the molecules of the compound with strong polarity is weak, making it difficult to overcome the attraction between the molecules of the compound.
In addition, its density is about 1.2-1.3 g/cm ³. The value of the density is affected by the molecular structure and the accumulation method. It has practical guiding significance for chemical operations involving the relationship between mass and volume, such as solution preparation and reaction metrology.
Its stability is also one of the important physical properties. It can be maintained relatively stable under normal temperature and pressure, protected from light and dry environments. However, when exposed to extreme conditions such as strong acids, strong bases, or high temperatures and light, the molecular structure may change, resulting in changes in chemical properties. This stability comes from the strength of the chemical bonds in the molecule and the stability of the spatial structure. Therefore, when storing and using the compound, such factors need to be fully considered to ensure the integrity of its properties and functions.
What is the synthesis method of 4-amino-1-isobutyl-1h-imidazo [4,5-c] quinoline
The synthesis of 4-amino-1-isobutyl-1H-imidazo [4,5-c] quinoline (4-amino-1-isobutyl-1H-imidazolo [4,5-c] quinoline) is a very important issue in organic synthetic chemistry. The synthesis of this compound requires ingenious strategies and delicate steps.
The first to bear the brunt, the selection of starting materials is the key. Quinoline derivatives with suitable substituents and imidazoles containing isobutyl groups can often be selected as starting materials. The chemical activity and structural characteristics of these two will lay the foundation for the synthesis path. < Br >
The first step in the synthesis is usually the nucleophilic substitution reaction of quinoline derivatives under specific conditions. In a suitable base and solvent system, the specific position of quinoline is activated so that it can react smoothly with imidazole compounds. This reaction requires precise regulation of temperature, reaction time and reactant ratio to obtain higher yield and good selectivity.
Next, for the intermediate product generated, an amination step is required. Ammonia sources, such as ammonia gas or ammonia derivatives, can be used to introduce amino groups at specific positions in the presence of catalysts. The choice of catalyst is extremely important, or a transition metal catalyst, which can effectively promote the reaction and optimize the reaction conditions to avoid unnecessary side reactions.
Furthermore, the purification and separation steps in the reaction process cannot be ignored. After each step of the reaction, the target product needs to be separated and purified from the reaction mixture by means such as column chromatography and recrystallization to ensure the purity of the product and provide high-quality raw materials for the next reaction. < Br >
In the synthesis of 4-amino-1-isobutyl-1H-imidazo [4,5-c] quinoline, the steps are closely linked. Precise control of reaction conditions, quality assurance of raw materials and reagents, and strict purification of each step are all key elements for the successful synthesis of this compound. In this way, the synthesis of 4-amino-1-isobutyl-1H-imidazo [4,5-c] quinoline can be achieved efficiently and with high quality.
4-amino-1-isobutyl-1h-imidazo [4,5-c] What are the relevant safety precautions for quinoline?
4-Amino-1-isobutyl-1H-imidazolo [4,5-c] quinoline This substance is related to safety. There are many things to pay attention to. I will describe it in detail for you.
First, it is related to toxicity. The toxicity of this compound should not be underestimated, or it may cause harm to many organs and systems of the human body. If it is accidentally touched, or inhaled through the skin, eaten through the mouth, or entered through the respiratory tract, it can cause different degrees of toxic and side effects. If the skin touches it, it may cause redness, swelling, itching, and tingling; if it enters the eye, its irritation is so strong that it can damage the eye tissue and even endanger the vision. Therefore, when handling this substance, it is necessary to strictly wear protective equipment, such as gloves, goggles, protective clothing, etc., to prevent contact between the skin and the eyes.
Second, its chemical activity also needs attention. Under specific conditions, or react violently with other substances. In case of strong oxidants, strong acids, strong alkalis, etc., or cause chemical reactions to get out of control, or even cause the danger of combustion and explosion. Therefore, when storing, avoid such chemicals and place them in a cool, dry and well-ventilated place to prevent unexpected changes.
Furthermore, the environmental impact should not be ignored. If this substance escapes in the environment, or is transmitted by water, soil, or air, it will damage the ecosystem. Or affect the survival and reproduction of aquatic organisms, or accumulate in the soil, affecting plant growth. Therefore, after use, its waste should be properly disposed of in accordance with environmental regulations and should not be discarded at will.
Again, operating standards are essential. In the experimental or production site, there should be good ventilation facilities to dissipate harmful gases that may be generated. Operators need to be professionally trained and familiar with operating procedures and emergency response methods. In the event of an accident such as leakage or ingestion, they should be able to respond quickly and correctly to reduce the damage.
In short, the treatment of 4-amino-1-isobutyl-1H-imidazolo [4,5-c] quinoline should be treated with caution and follow safety regulations to ensure the safety of personnel and the environment.