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What is the chemical structure of 4- {3-chloro-4- [ (cyclopropylcarbamoyl) amino] phenoxy} -7-methoxyquinoline-6-carboxamide?
This is a chemical nomenclature, and in order to know its chemical structure, it is necessary to analyze it according to the nomenclature. "4 - {3-chloro-4- [ (cyclopropanoformyl) amino] phenoxy} -7 -methoxyquinoline-6-formamide", which is composed of many parts.
"Quinoline" is the basic parent nucleus and has a nitrogen-containing heterocyclic structure. "7-methoxy" indicates that there is a methoxy group (-OCH 🥰) at the 7th position of the quinoline parent nucleus; "6-formamide", that is, there is a formamide group (-CONH ²) at the 6th position.
Look at the phenoxy part again, "3-chloro-4- [ (cyclopropanoyl) amino] phenoxy", indicating that the benzene ring has a chlorine atom (-Cl) at position 3, and a (cyclopropanoyl) amino group at position 4. Cyclopropanoyl, which is connected to a formyl group (-CO-), this formyl group is connected to the amino group and then connected to the benzene ring at position 4, and the phenoxy group is connected to the quinoline parent nucleus at position 4 as a whole.
So, according to this naming convention, the chemical structure of "4- {3-chloro-4- [ (cyclopropionyl) amino] phenoxy} -7-methoxyquinoline-6-formamide" can be constructed.
What are the main uses of 4- {3-chloro-4- [ (cyclopropylcarbamoyl) amino] phenoxy} -7-methoxyquinoline-6-carboxamide?
4 - {3-Chloro-4- [ (cyclopropionyl) amino] phenoxy} -7-methoxyquinoline-6-formamide, this is an organic compound. Its main use is often found in the field of medicinal chemistry.
In the process of drug development, many organic compounds exhibit potential biological activities due to their unique chemical structures and characteristics. This compound may have specific pharmacological activities, or it may act on specific targets in organisms, affect certain physiological processes, and then demonstrate value in the treatment of diseases.
Or it can be studied for specific diseases, such as inflammation, tumors, etc. For example, when exploring drugs to treat inflammation, researchers screen various compounds. If this compound can regulate inflammation-related signaling pathways, inhibit the generation and release of inflammatory mediators, or become a key raw material for the development of anti-inflammatory drugs.
Or in the development of anti-tumor drugs, if it can interfere with tumor cell proliferation, invasion or induce tumor cell apoptosis, it is expected to become a lead compound for new anti-tumor drugs, laying the foundation for subsequent drug design and optimization.
Furthermore, in the field of medicinal chemistry, it may also serve as a template for structural modification. Researchers implement chemical modifications according to their structural characteristics, hoping to obtain drug molecules with better activity and higher safety. The modified derivatives may have better pharmacokinetic properties, such as better solubility and stability, thus enhancing the efficacy and application prospects of the drug.
What are the synthesis methods of 4- {3-chloro-4- [ (cyclopropylcarbamoyl) amino] phenoxy} -7-methoxyquinoline-6-carboxamide?
To prepare 4 - {3-chloro-4- [ (cyclopropanoyl) amino] phenoxy} -7-methoxyquinoline-6-formamide, there are three methods.
One is to react 3-chloro-4-aminophenol with cyclopropanoyl chloride to obtain 3-chloro-4- [ (cyclopropanoyl) amino] phenol, and then react with 4,7-dichloro-7-methoxyquinoline-6-formamide under alkali catalysis to obtain the target by condensation. The raw materials are easy to obtain in this way, but the reaction conditions need to be precisely controlled. The amount of alkali, reaction temperature and time are all critical, and the yield will be affected if there is a slight difference in the pool.
The second is to prepare 4,7-dichloro-7-methoxyquinoline-6-formamide first, react with 3-chloro-4-hydroxyaniline to obtain an intermediate product, and then react with cyclopropanoyl chloride. This diameter step is slightly complicated, but the reaction of each step is relatively mild, which requires slightly less equipment. However, the separation and purification of intermediate products requires fine operation, otherwise impurities will affect the purity of the final product.
The third is to start with 7-methoxy-6-quinolinecarboxylic acid, and first form acyl chloride, which reacts with 3-chloro-4- [ (cyclopropionyl) amino] aniline. This way, the starting material is single and the process is short, but the price of 7-methoxy-6-quinolinecarboxylic acid may be higher, and the acyl chloride forming step requires an anhydrous environment, which requires strict reaction equipment and operation. If there is a little carelessness, there will be many side reactions.
All synthesis methods have their own advantages and disadvantages. The actual selection needs to comprehensively consider factors such as raw material cost, equipment conditions, product purity and yield, and weigh the advantages and disadvantages to choose the best method.
What are the physical properties of 4- {3-chloro-4- [ (cyclopropylcarbamoyl) amino] phenoxy} -7-methoxyquinoline-6-carboxamide?
4- {3-Chloro-4- [ (cyclopropionyl) amino] phenoxy} -7-methoxyquinoline-6-formamide, this is an organic compound. Its physical properties are quite important, and it is related to its performance in various chemical processes and practical applications.
First of all, the appearance is usually white to white crystalline powder. This form makes the compound easy to handle and operate in many scenarios, and its powder shape is convenient for accurate weighing and mixing.
Melting point is also one of the key physical properties. After experimental determination, its melting point is in a specific temperature range, which is of great significance for the determination of the purity of the compound. If the purity is high, the melting point range is relatively narrow and stable; if it contains impurities, the melting point will shift and the range will become wider. This property is helpful for quality control and purity analysis.
In terms of solubility, the compound has a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide. In dichloromethane, it can form a homogeneous solution, which is conducive to serving as a reaction medium in organic synthesis reactions, allowing the reactants to be fully contacted and accelerating the reaction rate. However, the solubility in water is very small, and this difference determines its separation, purification and application scenarios.
In terms of stability, under conventional environmental conditions, the compound is relatively stable. However, when exposed to strong acids, strong bases or high temperatures, the structure may change. If in a strong acid environment, its amide bonds may be hydrolyzed, which affects its chemical properties and functions. Therefore, it is necessary to avoid acid and alkali and control temperature during storage to maintain its stability and integrity.
4- {3-chloro-4- [ (cyclopropylformyl) amino] phenoxy} -7 -methoxyquinoline-6-formamide The physical properties of the amide are of important guiding value for its production, storage and application in the fields of organic synthesis and drug research and development.
What is the market outlook for 4- {3-chloro-4- [ (cyclopropylcarbamoyl) amino] phenoxy} -7-methoxyquinoline-6-carboxamide?
Nowadays, there are compounds called 4- {3-chloro-4- [ (cyclopropanoformyl) amino] phenoxy} -7-methoxyquinoline-6-formamide. Looking at its market prospects, it is actually complex and changeable.
This compound may have potential value in the field of pharmaceutical research and development. Due to its unique chemical structure, it is expected to become a key ingredient in new drugs. Today's pharmaceutical market is hungry for innovative drugs, and many pharmaceutical companies and scientific research institutions are doing their best to explore new and effective treatment methods. If this compound can demonstrate good pharmacological activity and safety, it may emerge in the field of treatment of specific diseases and gain market favor.
If you want to reach this state, it is not a smooth road. The research and development of new drugs takes a long time, requires huge investment, and is extremely risky. From laboratory research to clinical trials, and then to approval for marketing, you need to go through many barriers. Each step requires rigorous experiments and a large amount of data support. If there is a slight mistake, it may be in vain.
In the field of chemical materials, it may also have applications. For example, in the synthesis of some high-performance materials, as a special additive or monomer, it endows the material with unique properties. However, the chemical market is highly competitive, and various new materials are emerging one after another. If this compound wants to get a share of the pie, it needs to have significant advantages in performance and cost.
In addition, the market environment is also influenced by many factors such as policies and regulations, economic situation, etc. Policies encourage innovation, and may support the research and development of new compounds that meet the conditions; while economic fluctuations may affect R & D investment and market consumption capacity.
In summary, the market prospect of 4- {3-chloro-4- [ (cyclopropylformyl) amino] phenoxy} -7-methoxyquinoline-6-formamide, although there are opportunities, there are many challenges. Only with a solid R & D foundation, keen market insight and flexible response strategies can we have the opportunity to gain a place in the market.