(3s)-N-Tert-Butyl-3,4-Dihydro-1h-Isoquinoline-3-Carboxamide

The chemical structure of (3S) -N-tert-butyl-3,4-dihydro-1H-isoquinoline-3-formamide is a key content in the field of organic chemistry. This compound has a specific atomic arrangement and chemical bonding method.
From its naming analysis, (3S) shows that the compound has a specific three-dimensional configuration at the third position of carbon and is S-type. "N-tert-butyl" means that the nitrogen atom is connected to tert-butyl. Tert-butyl is a group containing three methyl groups connected to the same carbon atom, and the structure is stable. " 3,4-Dihydro-1H-isoquinoline "presents its core skeleton as an isoquinoline structure, but double-bond hydrogenation is introduced at the 3rd and 4th positions to form a partially saturated heterocyclic structure. Isoquinoline itself is a double-ring system formed by fusing benzene ring and pyridine ring, which gives the compound unique chemical activity." 3-Formamide "indicates that the isoquinoline ring is connected to formamido and formamido-CONH ² at the 3rd position, which contains both carbonyl and amino groups, so that it can participate in various chemical reactions, such as the formation and fracture of amide bonds.
Its overall chemical structure integrates the steric hindrance effect of tert-butyl, the conjugation stability of isoquinoline ring, and the reactivity of formamide group. It may have important uses in pharmaceutical chemistry, organic synthesis, etc., such as being used as a lead compound for structural modification and activity optimization to develop new drugs.

(3S) -N-tert-butyl-3,4-dihydro-1H-isoquinoline-3-formamide is one of the organic compounds. Its physical properties are unique and related to many aspects.
Looking at its appearance, it often takes the form of white to white solid powder. This form is conducive to storage and transportation, and is easy to identify. The powder is fine in texture, gently twisted in the hand, and feels smooth to the touch. It is like fine sand but more soft.
When it comes to the melting point, this compound undergoes a phase transition within a specific temperature range. The exact value of its melting point fluctuates slightly due to factors such as preparation process and purity, but it is roughly in a stable range. When the external temperature gradually rises near the melting point, the substance quietly melts from solid to liquid, just like ice and snow melting in the warm sun, and the process is smooth and orderly.
In terms of solubility, (3S) -N-tert-butyl-3,4-dihydro-1H-isoquinoline-3-formamide exhibits different solubility characteristics in organic solvents. In common organic solvents, such as dichloromethane and chloroform, it can be well dissolved, just like salt dissolves in water, and can be uniformly mixed with solvents to form a clear solution. However, in water, its solubility is poor, just like oil floating on the water surface, and it is difficult to blend. This characteristic also determines its application choice in different reaction systems.
In addition, the compound has a moderate density, although it is not as heavy as a metal, nor is it comparable to a lightweight foam. The value of its density provides a specific physical basis for its actual operation and use, affecting such as the sedimentation or suspension state in solution.
Its various physical properties are key elements for the study and application of this compound, helping researchers to gain insight into its characteristics, and then rationally apply it to various fields, such as drug synthesis, organic chemistry research, etc., to exert its unique value.

The synthesis method of (3S) -N-tert-butyl-3,4-dihydro-1H-isoquinoline-3-formamide is an important topic in the field of organic synthesis. Its synthesis route has been explored by many scholars in the past, and the method described above is for you.
First, isoquinoline is used as the starting material. First, isoquinoline is introduced into the carboxyl functional group at the third position under specific reaction conditions under the action of suitable reagents to obtain 3-carboxyl isoquinoline derivatives. Then, the 3,4-double bond is hydrogenated and reduced, and the method of catalytic hydrogenation can be used to achieve double bond reduction with noble metal catalysts, such as palladium carbon, under suitable temperature and pressure conditions, to obtain 3,4-dihydro-3-carboxyisoquinoline. Subsequently, the carboxyl group is converted into an amide group, which can be amidated with tert-butylamine in a condensing agent, such as carbodiimide reagents, to obtain the target product (3S) -N-tert-butyl-3,4-dihydro-1H-isoquinoline-3-formamide. < Br >
Second, the o-halobenzyl halide and enamide compound are used as raw materials. The nucleophilic substitution reaction of the two first occurs to construct the prototype of the isoquinoline parent nucleus. Then through the subsequent steps, the specific position on the ring is modified to introduce carboxyl groups and tert-butyl amide groups. For example, under the action of a suitable base, the o-halobenzyl halide reacts with enamines to form a preliminary product. Then through hydrolysis, oxidation and other steps, the carboxyl group is constructed at the third position, and then through reduction and amidation reactions, the synthesis of the target product is completed. This path requires fine control of the reaction conditions of each step to ensure the selectivity and yield of the reaction.
Third, the bionic synthesis strategy is adopted Simulate the relevant synthetic pathways in vivo, with natural products or fragments with similar structures as the starting materials. Through enzyme catalysis or mild chemical reactions, the structure is gradually modified to guide the synthesis of the target product. This method is green and environmentally friendly, but it requires strict reaction conditions, requires accurate simulation of the in vivo environment, and the acquisition and application of related enzymes are also challenging.
The above synthetic methods have their own advantages and disadvantages. Organic synthesizers can choose the best one according to actual needs, such as raw material availability, cost considerations, product purity requirements, etc., and can efficiently synthesize (3S) -N-tert-butyl-3,4-dihydro-1H-isoquinoline-3-formamide.

(3S) -N-tert-butyl-3,4-dihydro-1H-isoquinoline-3-formamide has a wide range of uses. In the field of pharmaceutical research and development, it is often a key intermediate, helping to synthesize compounds with specific biological activities, or the creation of therapeutic drugs involved in nervous system diseases, cardiovascular diseases, etc. Because of its unique chemical structure, it can bind to specific targets in organisms to show pharmacological effects, so it is an important cornerstone for the development of new drugs.
In the field of organic synthesis, it can be used as an important structural unit to build complex organic molecules through various chemical reactions, expand the structural diversity of organic compounds, and provide key building blocks for materials science, total synthesis of natural products, etc., to promote the development of related fields.
In the field of scientific research and exploration, as a research object, scientists use their investigation of their chemical properties, reactivity, and interactions with biomacromolecules to deepen their understanding of the basic theories of organic chemistry and biochemistry, contribute to the development of the discipline, and promote the expansion of scientific frontiers.

(3S) -N-tert-butyl-3,4-dihydro-1H-isoquinoline-3-formamide, when using this product, many matters must not be ignored.
First, safety is the first priority. Although there is no detailed toxicity data, when operating, you still need to be careful not to let it come into contact with the skin and eyes. If you accidentally touch it, rinse it with plenty of water quickly, and seek medical consultation if necessary. At the operation site, good ventilation must be done to prevent the accumulation of steam and cause accidents.
Second, stability is also key. This product is quite sensitive to light and heat. When storing, it should be placed in a cool, dry and dark place, and the temperature should also be strictly controlled to prevent deterioration. Before use, be sure to check the appearance and properties carefully. If there is any abnormality, do not use it.
Third, accurate weighing is about success or failure. Because it is often used in fine synthesis or experiments, whether the dosage is accurate or not has a significant impact. When weighing, precise instruments are required to avoid errors in the operation process to ensure the accuracy of the experiment or production.
Fourth, the chemical reaction conditions are complex and changeable. When participating in the reaction, the product and reaction rate are different under different conditions. Be sure to strictly control the temperature, pH, reaction time and other conditions according to the specific reaction, carefully observe the reaction process, and make detailed records.
Fifth, compatibility taboos cannot be ignored. When combined with specific chemical substances, adverse reactions may occur. Before use, when fully understanding its chemical properties and avoiding contact with contraindicated substances, if mixed, do a small test to confirm that it is safe before large-scale operation.