(3S)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride

(3S) -6,7-diacetoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic anhydride, its chemical structure is as follows.
This compound has an isoquinoline ring as its core structure. At position 3, the carboxyl group with a specific stereoconfiguration is dehydrated and condensed to form an acid anhydride structure, which is labeled with (3S) to indicate its stereochemical characteristics. At positions 6 and 7, there are acetoxy groups, which are connected to the carbon of the isoquinoline ring through oxygen atoms. Positions 1, 2, 3, and 4 participate in the formation of the tetrahydroisoquinoline part, indicating that positions 1, 2, 3, and 4 of the isoquinoline ring are hydrogenated, which reduces its unsaturation.
This structure endows the compound with unique chemical properties. The anhydride structure has high reactivity and is easy to react with nucleophiles, such as alcohols, amines, etc., to form corresponding esters or amides. Acetoxy groups can be hydrolyzed under appropriate conditions to release acetic acid and hydroxyl-containing isoquinoline derivatives. The existence of tetrahydroisoquinoline parts affects the electron cloud distribution and spatial conformation of molecules, and also plays an important role in their physicochemical properties and biological activities. The various characteristics of this structure make (3S) -6,7-diacetoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid anhydride have potential application value in organic synthesis and medicinal chemistry.

(3S) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic anhydride is a key intermediate in organic synthesis. It has a wide range of main uses and is of important value in many fields.
In the field of medicinal chemistry, this compound is often used as a key building block for the synthesis of various biologically active drug molecules. Due to its unique chemical structure, it can endow drug molecules with specific spatial configuration and chemical properties, which helps to improve the binding affinity of drugs and targets, thereby enhancing the efficacy of drugs. For example, in some drug development for neurological diseases, this intermediate will be used to design ligands with high selectivity for neurotransmitter receptors by modifying their surrounding chemical groups, providing potential drug lead compounds for the treatment of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.
In the field of total synthesis of natural products, (3S) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic anhydride also plays an indispensable role. Many natural products with complex structures contain similar structural units in their core skeletons. By using this intermediate as a starting material and applying the strategies and methods of organic synthetic chemistry, complex structures consistent with natural products can be gradually constructed, thus realizing the total synthesis of natural products. This not only helps to deeply explore the biological activity and mechanism of action of natural products, but also lays the foundation for the development of innovative drugs based on natural products.
Furthermore, in the field of materials science, this compound also shows potential application prospects. By appropriate chemical modification and modification, it can be made to possess specific optical, electrical or thermal properties, which are expected to be applied to the preparation of new functional materials, such as organic Light Emitting Diode (OLED) materials, sensor materials, etc., providing new opportunities and directions for the development of materials science.

The preparation of (3S) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic anhydride is the key to organic synthesis. This compound has a wide range of uses in the field of medicinal chemistry, so its preparation method has attracted much attention.
To prepare (3S) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic anhydride, the conventional method. First, with suitable starting materials, the core skeleton is constructed through multi-step reaction, and then ethoxy and carboxyl groups are introduced, and finally the anhydride is formed. This process requires fine regulation of reaction conditions, such as temperature, pH, reaction time and ratio of reactants.
First take the nitrogen-containing heterocyclic compound and treat it with appropriate nucleophiles to construct the isoquinoline skeleton. This step requires the selection of suitable solvents and catalysts to promote the efficient progress of the reaction. Commonly used catalysts such as metal salts or organic bases, and solvents are selected depending on the reaction requirements.
Next, ethoxy groups are introduced into the skeleton. The reaction of halogenated hydrocarbons and sodium alcohols can be used, which is a classic nucleophilic substitution reaction. Precise control of reaction conditions ensures accurate positioning of ethoxy groups and avoids side reactions.
After the ethoxy group is introduced, a carboxyl group is constructed. Or a specific functional group is converted into a carboxyl group by oxidation reaction; or a reagent containing a carboxyl group is introduced by substitution or addition reaction.
Finally, the carboxyl group is dehydrated to form an anhydride. In this step, a dehydrating agent, such as acetic anhydride, phosphorus oxychloride, etc., is used to realize the conversion of carboxylic acid to acid anhydride at an appropriate temperature and reaction time. The whole preparation process requires strict control of each step to obtain high-purity (3S) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid anhydride.

(3S) -6,7-dimethyloxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic anhydride is a kind of organic compound. Its physical and chemical properties are as follows:
Looking at its properties, it is in a solid state at room temperature and pressure, but it also varies slightly depending on the specific purity and surrounding environmental conditions. As for the melting point, the melting point is given a certain value by the specific structure due to the interaction between molecules, but to know it accurately, it needs to be determined experimentally, about several degrees Celsius; the boiling point is also in a certain temperature range due to similar factors to ensure that the molecule breaks free from the liquid phase and gasifies. < Br >
In terms of solubility, it may exhibit a certain solubility in organic solvents, such as ethanol, dichloromethane, etc. Due to the principle of similar miscibility, the force between the molecules of the organic solvent and the compound can promote its dispersion. In water, the solubility may be limited, because the hydrophilic groups in the molecular structure are relatively scarce, and the interaction with water molecules is weak.
Once again on its chemical properties, the acid anhydride structure in the molecule is active and easy to react with nucleophiles. In case of water, it can be hydrolyzed to produce corresponding carboxylic acids. In case of alcohols, under suitable conditions, an alcoholysis reaction may occur to form ester products. And because of its nitrogen-containing heterocyclic structure, the lone pair electrons on the nitrogen atom can participate in various reactions, such as reacting with acids to form salts, or participating in electrophilic substitution reactions under specific conditions, introducing other groups on the heterocyclic ring, and then deriving a variety of chemical transformations, which are quite useful in the field of organic synthesis.

(3S) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic anhydride, which is a rather special chemical substance. However, the market price is difficult to say exactly.
Due to the intertwining of many factors, its price fluctuates. First, the cost of raw materials has a great impact. If the starting materials required to synthesize this compound are scarce or expensive to obtain, the price of the final product will rise. Second, the complexity of the preparation process also affects the price. If precise reaction conditions, lengthy steps or special catalysts are required, the preparation cost will increase significantly, which will increase the price. Third, the amount of market demand is the key factor. If an industry has strong demand for this substance and limited supply, its price will rise; otherwise, there is little demand, and the price may also decrease.
In addition, the prices quoted by different suppliers are also very different due to differences in production scale, technical level, and operating costs. In addition, factors such as market competition, international trade policies, and exchange rate fluctuations are mixed in, making their prices even more unpredictable. Therefore, in order to obtain the exact price of (3S) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic anhydride, it is necessary to consult the relevant chemical product suppliers in detail, and combine multi-party quotations and market facts before a conclusion can be reached.