(3s,4as,8as)-n-(1,1-dimethylethyl)decahydro-2-[(2r,3r)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide mesylate

This is the name given to a complex organic compound. To understand its chemical structure, the following steps are required to analyze it.
" (3s, 4as, 8as) -n- (1,1-dimethylethyl) decahydro-2- [ (2r, 3r) -2 -hydroxy-3- [ (3-hydroxy-2-methylbenzoyl) amino] -4 - (phenylthio) butyl] -3 -isoquinoline formamide, methanesulfonate".
" (3s, 4as, 8as) " is a chiral central configuration identifier, revealing a specific atomic spatial arrangement. " N- (1,1 -dimethylethyl) "indicates that there is an isopropyl group attached to the nitrogen atom." Decahydro "means that the double bond of the isoquinoline ring system is fully hydrogenated to a saturated state.
" 2- [ (2r, 3r) -2 -hydroxy-3- [ (3-hydroxy-2-methylbenzoyl) amino] -4 - (phenylthio) butyl] ", this paragraph describes the 2-position side chain structure of the isoquinoline ring. (2r, 3r) is a chiral central configuration, and the side chain contains hydroxyl, benzoylamino and phenylthio.
"3-isoquinoline formamide" is determined to be an isoquinoline ring with a 3-position dimethamide group. "Methanesulfonate" refers to the salt formed by the compound and methanesulfonic acid.
In summary, this compound takes isoquinoline as the core, is connected with specific side chains and substituents, and forms methanesulfonate. Its structure is complex, and there are many chiral centers. Each group is connected according to specific rules to form a unique chemical structure.

(3S, 4aS, 8aS) -N- (1,1-dimethylethyl) decahydro-2- [ (2R, 3R) -2 -hydroxy-3- [ (3-hydroxy-2-methylbenzoyl) amino] -4- (phenylthio) butyl] -3 -isoquinoline formamide methanesulfonate, this drug has a wonderful pharmacological effect.
It can adjust the balance of the body, such as controlling external evil and restoring the integrity of the viscera. In the operation of qi and blood, it can smooth its flow and prevent it from stagnating. Viewing its effect on the veins and collaterals, so that the blood flow is orderly and nourishes the whole body.
And it can help the viscera perform their duties, such as assisting the transportation and transformation of the spleen, so that the water and valley are subtly distributed; benefiting the lungs and spreading, so that clear qi can enter and turbid qi can come out. Between the meridians and collaterals, it can also be blocked by it, so that the meridian qi can flow unimpeded.
It can also calm the mind and mind, make the emotions comfortable and not irritable. Its adjustment in the body, multi-pronged, is like a wonderful hand conditioning, so that the body and mind can return to a peaceful and healthy state, so it is valued by doctors, used to treat all kinds of discomfort, and has the ability to sink and rehabilitate.

This medicine is called (3S, 4aS, 8aS) -N- (1,1-dimethylethyl) decahydro-2- [ (2R, 3R) -2-hydroxy-3- [ (3-hydroxy-2-methylbenzoyl) amino] -4- (phenylthio) butyl] -3-isoquinolinformamide methanesulfonate. However, in ancient Chinese, it should be expressed in simple and elegant words.
This medicine is quite widely used in clinical practice. First, it is related to the treatment of diseases. It may be used for some difficult and miscellaneous diseases, which can adjust the yin and yang of the body, replenish the deficiency of qi and blood, and remove the infestation of evil poisons. If a person is suffering from deep illness, poor qi and blood flow, and dysregulation of the viscera, this medicine may dredge the meridians and collaterals, reconcile qi and blood, and make the body return to normal. Second, it can help the good luck of the viscera. If there is a disharmony in the viscera, such as the imbalance of the spleen and stomach, and the weakness of transportation and transformation, this medicine may help the spleen and stomach, so that the water and valley can be melted, the fine cloth can be obtained, and the whole body can be nourished. Third, it may have the power of adjuvant therapy for emotional diseases. If a person is emotionally depressed and has poor qi, this medicine may regulate qi and relieve depression, smooth the emotions, and make people feel at peace.
In clinical practice, it is often emphasized by doctors. It is applied to patients, hoping to cure depression and restore people's health. However, the way of medication requires a detailed review of the condition and weighing the pros and cons in order to cure the disease and live up to the kindness of the doctor and the efficacy of the medicine stone.

(3S, 4aS, 8aS) -N- (1,1-dimethylethyl) decahydro-2- [ (2R, 3R) -2-hydroxy-3- [ (3-hydroxy-2-methylbenzoyl) amino] -4- (phenylthio) butyl] -3-isoquinoline formamide methanesulfonate, the adverse reactions of this drug, the ancient saying.
It may cause gastrointestinal discomfort, such as nausea, vomiting, diarrhea. The spleen and stomach are the foundation of the day after tomorrow. The medicine enters the body and disturbs the qi machine of the spleen and stomach. If the stomach qi is reversed, it will be nauseated, and if the temper is unlucky, it will cause diarrhea.
In the liver, it may have an impact. The liver is the main drain, and the metabolism of the medicine may be tired of the liver, causing liver enzymes to rise. The liver is just and visceral, and the body is yin and yang is used. The bias of the medicine may disturb the balance of yin and yang, causing abnormal liver drain.
And it should not be underestimated for the blood system. Or cause thrombocytopenia and other diseases. If the blood is in the vein, it will nourish the whole body. If there are few platelets, it will hinder the opportunity of coagulation, and it is easy to see signs of
There are also reactions of the nervous system, such as dizziness and headache. The brain is the sea of marrow, the palace of the clear sun. The influence of medicine may cause the clear yang to not rise, the turbid yin to not fall, and the clear orifice to be blinded, so dizziness and headache.
All kinds of adverse reactions, when taking medicine, should be carefully observed and handled with caution to ensure the safety of medication.

There are currently compounds (3s, 4as, 8as) -n- (1,1-dimethylethyl) decahydro-2- [ (2r, 3r) -2-hydroxy-3- [ (3-hydroxy-2 -methylbenzoyl) amino] -4- (phenylthio) butyl] -3 -isoquinoline formamide methanesulfonate, which is synthesized according to the following steps.
First take the appropriate starting material, take the decahydroisoquinoline derivative as the base, and introduce the (1,1-dimethylethyl) group under specific reaction conditions. This step requires a mild reaction environment to avoid side reactions. The reagents used need to be pure and have accurate proportions. For example, a halogenated (1,1-dimethylethyl) reagent, under the catalysis of a base, interacts with decahydroisoquinoline derivatives, and the temperature is controlled within a certain range to make the reaction sufficient and orderly.
Then, construct (2r, 3r) -2 -hydroxy-3- [ (3-hydroxy-2-methylbenzoyl) amino] -4- (benzenthio) butyl side chain. First, a suitable butene derivative is used to introduce hydroxyl, phenylthio and other groups in sequence through several steps of reaction. Each step requires precise control of the three-dimensional configuration. When a hydroxyl group is introduced, a chiral catalyst can be used to guide the product of a specific configuration. After the side chain is constructed, it is connected to the 2-position of the decahydroisoquinoline derivative by a condensation reaction. In this step, attention should also be paid to the selection of reaction conditions, such as solvent, temperature, catalyst type, etc., in order to achieve the best reaction effect.
Finally, the resulting product interacts with methanesulfonic acid to form methanesulfonate. This step requires controlling the pH, temperature and reaction time of the reaction to complete the salt-forming reaction and ensure the purity and stability of the product. Throughout the synthesis process, each step requires fine operation, strict control of the reaction conditions, and precise calibration of the instruments used, so that the target product can be obtained.