(3S,4aS,10aR)-3-(Diethylsulfamoylamino)-6-hydroxy-1-propyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline hydrochloride

This is a description of the chemical structure of an organic compound. Its name is quite complicated. Take (3S, 4aS, 10aR) -3- (diethoxy phosphoryl oxide) -6-methoxy-1-methyl-3,4,4a, 5,10,10a-hexahydro-2H-naphthaleno [g] m-dioxane-2-one as an example. To clarify its structure, it can be analyzed from the following.
First, the three-dimensional configuration label (3S, 4aS, 10aR), which depends on the configuration of chiral carbon atoms, indicating that the specific spatial arrangement of molecules is crucial in determining the physicochemical properties and biological activities of compounds. < Br >
The main structure was again examined, and it was naphthalene and [g] m-dioxane, which is the organic structure of polycyclic. Naphthalene ring is a fused cyclic aromatic hydrocarbon with a conjugated system and has certain stability. M-dioxane merges with it, making the overall structure more complex. At the 3rd position, there is a diethoxy phosphoryl group, which is introduced into phosphorus, or makes the compound have specific reactivity and properties. Methoxy group at the 6th position and methyl group at the 1st position have effects on the electron cloud distribution, polarity and steric resistance of the molecule. 3,4,4a, 5,10,10a - Hexahydro indicates that the naphthalene ring is partially hydrogenated, which gives the molecule a unique configuration and properties. 2H - indicates the specific hydrogen atom number and connection method of this compound. The 2-keto ring contains carbonyl groups, which have high reactivity and can participate in many chemical reactions.
The structure of this compound is determined by the rules and methods of organic chemistry, and its properties and functions are determined by the interaction of various parts. It may be of great significance in the fields of organic synthesis and medicinal chemistry.

(3S, 4aS, 10aR) -3- (diethoxy phosphoryl oxy) -6-fluoro-1-methyl-3,4,4a, 5,10,10a-hexahydro-2H-benzo [g] quinoline-2-one, this drug has multiple pharmacological functions. It can act on the nervous system, or can regulate nerve conduction, making the signal transmission between nerve cells smoother, in some neurological dysfunction symptoms, or have the effect of improving. In the cardiovascular system, or can regulate vascular tension, maintain moderate vascular contraction and relaxation, help stabilize blood pressure, and ensure normal blood circulation. In addition, it may also affect the immune system, or it can regulate the activity of immune cells, enhance the body's ability to resist external evil, and in the case of low immune function, it may play a corrective effect. Or it can intervene in the process of cell metabolism, affecting the proliferation and differentiation of cells, etc., in order to achieve the purpose of treating related diseases. In short, this drug shows its unique pharmacological efficacy by acting on multiple systems and links, providing assistance for the treatment of related diseases.

(3S, 4aS, 10aR) -3- (diethoxy phosphoryl) -6-fluoro-1-methyl-3,4,4a, 5,10,10a-hexahydro-2H-benzo [g] quinolinic acid The chemical reaction of this compound is widely used in the field of pharmaceutical synthesis. The process of covering the creation of medicine often requires the construction of complex molecular structures with specific activities, and the reactions involved in this compound may be a key step in the synthesis of drug molecules with specific structures.
In the development of anti-tumor drugs, it may be able to build a core skeleton through this reaction, endowing the drug with the ability to precisely bind to tumor cell targets, and inhibit tumor growth by interfering with key processes such as tumor cell proliferation and differentiation. In the development of drugs for the treatment of neurological diseases, the unique structure of this reaction product may regulate neurotransmitter transmission, improve nerve cell function, and provide new ideas for the treatment of related diseases.
Furthermore, in the field of anti-infective drugs, compounds synthesized based on this reaction may have unique antibacterial and antiviral activities, showing high-efficiency inhibitory effects against specific pathogens, injecting new vitality into the development of anti-infective drugs. These are all common application scenarios of (3S, 4aS, 10aR) -3- (diethoxy phosphoryl) -6-fluoro-1-methyl-3,4,4a, 5,10,10a-hexahydro-2H-benzo [g] quinolinate related reactions in the field of pharmaceutical synthesis, which are of great significance for promoting the development of medicine.

(3S, 4aS, 10aR) -3- (diethoxy phosphoryloxy) -6-fluoro-1-methyl-3,4,4a, 5,10,10a-hexahydro-2H-benzo [g] quinolinic acid esters exhibit specific chemical properties in many reactions. Among them, due to its unique molecular structure, in the nucleophilic substitution reaction, the phosphoryloxy site of these compounds has a small spatial barrier, and the electron cloud distribution is suitable. For some nucleophiles, the reaction can occur more smoothly without showing obvious disadvantages. < Br >
In terms of oxidation reaction, due to the quinoline structure and surrounding substituents in its molecule, when some milder oxidizing agents are used, the compound can exist stably and will not be damaged by oxidation, and will not undergo changes that are not conducive to the expected reaction process. This is because some groups in its structure can play a certain buffering role in the oxidizing agent, avoiding the occurrence of excessive oxidation.
In the reaction under high temperature environment, if such compounds participate in some intramolecular rearrangement reactions, because their hexahydrobenzoquinoline ring system has certain rigidity and stability, within a certain temperature range, there will be no adverse reactions such as ring rupture or excessive isomerization due to high temperature, which can maintain the relative stability of the structure and make the reaction proceed in the expected direction. However, if there are strong acidic or strong basic substances in the reaction system and under high temperature conditions, then there may be adverse situations such as destroying the molecular structure and affecting the reaction selectivity.

To prepare (3S, 4aS, 10aR) -3- (diethoxy phosphoryl oxy) -6-methoxy-1-methyl-3,4,4a, 5,10,10a-hexahydro-2H-naphthalene and [g] quinoxaline-2-one, the method is as follows:
First take an appropriate amount of starting material, when the compound with a specific spatial configuration is used as the base, this configuration is related to the (3S, 4aS, 10aR) configuration of the target product. The raw material undergoes many delicate transformations to obtain this target product.
First, apply specific reaction conditions to the raw material, and add an appropriate amount of reagent in a suitable reaction vessel. The reagents involved need to be carefully selected, and their activity and selectivity have a significant impact on the reaction process. Taking phosphorus-containing reagents as an example, after precise measurement, they react with specific groups in the raw material. This step aims to introduce diethoxy phosphoryl groups. The reaction temperature and duration need to be properly controlled. The temperature may vary from tens of degrees Celsius to 100 degrees Celsius depending on the difficulty of the reaction, and the duration may take several hours or even days to ensure that the reaction is complete.
Second, when introducing the structural unit of hexahydronaphthalene and quinoxaline, an ingenious cyclization reaction can be used. By adjusting the pH of the reaction system and selecting a suitable catalyst, the groups in the molecule can interact and cyclize to form the desired thick ring structure. In this cyclization reaction, the type and dosage of the catalyst are crucial, either metal salts or organic bases, and the dosage is proportionally allocated according to the amount of raw materials.
Third, the introduction of methoxy and methyl groups also needs to be paid attention to. The introduction of methoxy groups is often reacted with the raw materials under alkaline conditions with the corresponding halogenated methane, and the polarity of the reaction solvent needs to be carefully considered. The introduction of methyl groups, or through alkylation, can be combined with the active check point in the raw materials under specific conditions with suitable methylating reagents.
After the reaction, the product needs to be separated and purified. Methods such as column chromatography and recrystallization can be used to remove impurities to obtain pure (3S, 4aS, 10aR) -3- (diethoxy phosphoryl) -6-methoxy-1-methyl-3,4,4a, 5,10,10a-hexahydro-2H-naphthalene and [g] quinoxaline-2-one. Each step needs to be carefully controlled to ensure the purity and accuracy of the configuration of the product.