What is the chemical structure of (3S) 2- {N- [ (1S) -1- (ethoxycarbonyl) -3-phenylpropyl] -L-alanyl} -6,7-dimethoxy-1,2,3, 4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride?

This is the chemical structure analysis of (3S) - 2 - {N - [ (1S) - 1 - (ethoxycarbonyl) - 3 - phenylpropyl] - L - alanyl} - 6,7 - dimethoxy - 1,2,3,4 - tetrahydroisoquinoline - 3 - carboxylic acid hydrochloride.

Looking at its name, its main structure can be analyzed first. The configuration of the (3S) and (1S) chiral centers is crucial for determining the three-dimensional spatial arrangement of molecules. The main body contains the nucleus of tetrahydroisoquinoline - 3 - carboxylic acid, which is the key parent nucleus. The 6,7-dimethoxy group is attached to the parent nucleus, which affects the electron cloud distribution and physicochemical properties of the molecule.

2-site contact {N- [ (1S) -1- (ethoxycarbonyl) -3-phenylpropyl] -L-alanyl} group, this long chain structure is complex, (1S) -1- (ethoxycarbonyl) -3 -phenylpropyl is modified on the L-alanyl nitrogen atom, enriching the chemical diversity of the molecule. The ethoxycarbonyl group has the characteristics of an ester group, the phenyl group is hydrophobic to increase the molecule, and the alanyl is an amino acid residue, or it is involved in specific biological activities and interactions.

The form of hydrochloride shows that the molecule forms a salt with hydrogen chloride, which can change its solubility and stability, and is of great significance in the field of drug development. Overall, this chemical structure integrates multiple functional groups and chiral centers, and the parts cooperate to give the molecule unique physical, chemical and biological activities.

What are the physical properties of (3S) 2- {N- [ (1S) -1- (ethoxycarbonyl) -3-phenylpropyl] -L-alanyl} -6,7-dimethoxy-1,2,3, 4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride?

(3S) - 2 - {N - [ (1S) - 1 - (ethoxycarbonyl) - 3 - phenylpropyl] - L - alanyl} - 6,7 - dimethoxy - 1,2,3,4 - tetrahydroisoquinoline - 3 - carboxylic acid hydrochloride, this is an organic compound. Its physical properties are critical and affect many application fields.

When it comes to appearance, this compound usually appears as a white to white-like crystalline powder. This morphology is easy to observe and operate, and in the process of drug preparation, this appearance is conducive to quality control and subsequent processing. The melting point of

is also one of the important physical properties. Its melting point is specific, and during the heating process, a phase transition will occur at a certain precise temperature range. Accurately knowing the melting point helps to determine the purity of the compound, because impurities will change or reduce the melting point range.

In terms of solubility, it exhibits certain solubility characteristics in specific organic solvents. In common solvents such as water, ethanol, and dichloromethane, the solubility varies. In the aqueous phase, its solubility may be limited, while in some organic solvents, the solubility effect is better. This property has a profound impact on its application in different chemical reaction systems and drug formulations. For example, in drug development, appropriate dosage forms need to be designed according to their solubility to ensure that the active ingredients can be released and absorbed reasonably in the body.

In addition, the stability of the compound cannot be ignored. Under specific temperature, humidity and light conditions, the stability will change. High temperature, high humidity or strong light exposure may cause it to decompose and deteriorate, which affects its chemical structure and activity. Therefore, when storing and using, these physical properties need to be fully considered to maintain its quality and performance.

What is the synthesis method of (3S) 2- {N- [ (1S) -1- (ethoxycarbonyl) -3-phenylpropyl] -L-alanyl} -6,7-dimethoxy-1,2,3, 4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride?

The synthesis of (3S) 2- {N- [ (1S) -1- (ethoxycarbonyl) -3-phenylpropyl] -L-alanyl} -6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride is the key to organic synthesis.

To prepare this product, you can first take 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid as the initial raw material, and use an appropriate condensing agent, such as carbodiimide, to promote it to react with (N- [ (1S) -1- (ethoxycarbonyl) -3-phenylpropyl] -L-alanine in a suitable organic solvent, such as dichloromethane or N, N-dimethylformamide. This step requires attention to the reaction temperature and time. Generally, the temperature is controlled at 0 ° C to room temperature, and the reaction process is monitored for several hours. After the raw materials are exhausted, the intermediate product is obtained.

Then, the obtained intermediate product is acidified. Select a suitable inorganic acid, such as an alcoholic solution of hydrochloric acid, and add it dropwise to the reaction system to form a salt of the intermediate product, that is, (3S) -2-{ N- [ (1S) -1- (ethoxycarbonyl) -3-phenylpropyl] -L-alanyl} -6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride.

Or take another approach, use 1,2,3,4-tetrahydroisoquinoline as the starting material, first methoxylate, and introduce 6,7-dimethoxy groups. Subsequently, its 3-position access to carboxyl groups can be achieved by specific nucleophilic substitution or oxidation reactions. After that, the target product can also be obtained by following the above condensation and salt formation steps.

The whole process of synthesis, the purity of raw materials, the precise control of reaction conditions, and the appropriate means of separation and purification are all factors that affect the yield and purity of the product. During separation, column chromatography, recrystallization, etc. can be selected according to the characteristics of the product to obtain high-purity (3S) -2-{ N- [ (1S) -1- (ethoxycarbonyl) -3-phenylpropyl] -L-alanyl} -6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride.

What are the application fields of (3S) 2- {N- [ (1S) -1- (ethoxycarbonyl) -3-phenylpropyl] -L-alanyl} -6,7-dimethoxy-1,2,3, 4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride?

(3S) - 2 - {N - [ (1S) - 1 - (ethoxycarbonyl) - 3 - phenylpropyl] - L - alanyl} - 6,7 - dimethoxy - 1,2,3,4 - tetrahydroisoquinoline - 3 - carboxylic acid hydrochloride, this compound has a wide application field.

In the field of pharmaceutical research and development, it may have unique pharmacological activities. Cover because its structure contains a variety of functional groups and specific configurations, or can interact with specific targets in organisms. For example, the tetrahydroisoquinoline structure is often a key part of many bioactive compounds, or can act on the neurotransmitter system, and may have potential value in the treatment of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. It is expected to use this compound to develop new therapies.

In organic synthesis chemistry, its complex structure is also of concern to organic synthesis chemists. This compound can be used as a target product to test and develop new synthesis methods and strategies. The synthesis process requires precise control of each step of the reaction to ensure the accuracy of the stereochemical configuration, which helps to promote the progress of organic synthesis technology.

In pharmaceutical chemistry research, its structure can be modified to explore the relationship between structure and activity. By changing the substituents such as ethoxycarbonyl and phenyl, or adjusting the substitution mode on the tetrahydroisoquinoline ring, the activity, selectivity and pharmacokinetic properties of the compounds can be optimized, providing lead compounds for the creation of new drugs.

What is the market prospect of (3S) 2- {N- [ (1S) -1- (ethoxycarbonyl) -3-phenylpropyl] -L-alanyl} -6,7-dimethoxy-1,2,3, 4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride?

(3S) - 2 - {N - [ (1S) - 1 - (ethoxycarbonyl) - 3 - phenylpropyl] - L - alanyl} - 6,7 - dimethoxy - 1,2,3,4 - tetrahydroisoquinoline - 3 - carboxylic acid hydrochloride, this is a rather complex organic compound. In terms of the current market situation, this compound may have potential value in the field of pharmaceutical research and development.

Looking back at the past, many compounds with similar structures have been studied and discovered, showing unique biological activities, which may provide opportunities for the creation of new drugs. However, in order to gain insight into its market landscape, many factors must be considered in detail. First and foremost, the process complexity of synthesizing this compound is quite high, and the cost of raw materials may be high, which poses a serious challenge to its large-scale preparation and cost control.

From the perspective of demand, if it can be confirmed that it has definite efficacy for specific diseases, such as neurological diseases, cardiovascular diseases, etc., and the efficacy is better than that of existing drugs, the market demand may be considerable. However, the pharmaceutical market is highly competitive, and the road to new drug development is full of thorns. Clinical trials must go through many strict barriers before they can be approved for marketing.

Furthermore, regulations and policies are extremely strict in the supervision of pharmaceutical products. If this compound wants to enter the market, it must meet many regulatory requirements. Overall, (3S) -2- {N- [ (1S) -1- (ethoxycarbonyl) -3-phenylpropyl] -L-alanyl} -6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride has potential opportunities, but it also faces many challenges such as synthesis, clinical and regulatory. The market situation is still difficult to determine, and it needs to be further studied and explored.