As a leading (3S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of (3S) -10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2, 3-dihydro-7H- [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid
(3S) -10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid, this is an organic compound. To clarify its chemical structure, it needs to be explained according to the naming rules.
According to its name, "quinoline-6-carboxylic acid" indicates that the basic parent nucleus is quinoline and has a carboxyl group at the 6th position. The configuration of the carbon atom at the 3rd position of the " (3S) " table is S type. " 10- (1-aminocyclopropyl) "Table 10 is connected with a 1-aminocyclopropyl group, that is, there is an amino substitution on the cyclopropyl group." 9-fluoro "means that there is a fluorine atom substitution at the 9th position, and a methyl substitution at the 3rd position of" 3-methyl "Table 3." 7-oxo "means carbonyl at the 7th position." 2,3-dihydro-7H- [1,4] oxazino [2,3,4-ij] "indicates that the parent nucleus quinoline is combined with [1,4] oxazino, and the 2,3 positions are dihydro structures, and the 7H indicates that the 7 positions are occupied by hydrogen atoms.
So, the chemical structure of this compound is based on quinoline and modified by multiple substitutions and cyclization. Each substituent and cyclization structure endows its unique chemical properties and reactivity, which may be of important value in the fields of organic synthesis and medicinal chemistry.
What are the main uses of (3S) -10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2, 3-dihydro-7H- [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid
(3S) -10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid, this is an organic compound with a wide range of uses.
In the field of medicine, this compound may have antibacterial effects. Due to many quinoline carboxylic acid compounds, it has shown strong inhibition and killing ability against a variety of bacteria. These compounds can interfere with the function of bacterial DNA gyrase or topoisomerase IV, hinder the replication, transcription and repair of bacterial DNA, and then inhibit the growth and reproduction of bacteria. Therefore, (3S) -10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid or can be used to develop new antibacterial drugs to deal with various infections caused by sensitive bacteria, such as respiratory tract infections, urinary system infections, intestinal infections, etc.
This compound is also of great value in medicinal chemistry research. Its unique chemical structure provides a new research target and idea for medicinal chemists. By modifying and modifying its structure, derivatives with better pharmacological activity, lower toxic and side effects, and higher bioavailability may be obtained. This process is helpful for in-depth exploration of the structure-activity relationship of quinoline carboxylic acids, laying a solid foundation for the rational design and development of new antimicrobial drugs.
Furthermore, in the field of organic synthesis, this compound may serve as a key intermediate. With its specific functional groups and structural properties, it can participate in a series of organic reactions to construct more complex organic molecular structures. Organic synthesis chemists can further derive organic compounds by means of various chemical reactions, thus expanding the variety and application of organic compounds.
What is the synthesis method of (3S) -10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2, 3-dihydro-7H- [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid
(3S) - 10 - (1 - aminocyclopropyl) - 9 - fluoro - 3 - methyl - 7 - oxo - 2,3 - dihydro - 7H - [1,4] oxazino [2,3,4 - ij] quinoline - 6 - carboxylic acid, this is a complex organic compound. Its synthesis method, according to the ancient method, requires multiple steps of delicate reaction.
The choice of starting materials is crucial. Often based on quinoline derivatives with specific substituents, this derivative needs to be carefully pretreated to activate its specific check point and facilitate subsequent reactions. < Br >
The first step is to make the quinoline derivative undergo nucleophilic substitution reaction with the fluorine-containing reagent in an appropriate solvent at a specific temperature and under the action of a catalyst, and introduce fluorine atoms. This step requires precise control of the reaction conditions. Due to the introduction position and number of fluorine atoms, it has a profound impact on the structure and properties of the product. The dosage of fluorine reagent, reaction temperature and time need to be repeatedly debugged to achieve the desired reaction effect.
In the next step, a specific cyclization reagent is used to induce intramolecular cyclization to construct the core skeleton of oxazine and quinoline. This cyclization reaction requires precise control of the reaction process and vigilance against the occurrence of side reactions. The polarity of the reaction solvent and the pH of the reaction system are all key factors affecting the selectivity and yield of the cyclization reaction.
Re-introduce 1-aminocyclopropyl and methyl, and this process requires the selection of suitable aminocyclopropylation reagents and methylation reagents. Aminocyclopropylation reactions often need to be carried out slowly in an alkaline environment at low temperature to room temperature to ensure that the aminocyclopropyl is accurately connected to the target position. Methylation reactions require the selection of methylation reagents with moderate activity to avoid excessive methylation.
After each step of the reaction, it needs to go through a purification process, often used column chromatography, recrystallization and other methods to remove impurities and obtain pure intermediate products. The optimization of the reaction conditions at each step and the purification of the intermediate products are complementary and indispensable. In this way, the reaction can be carefully designed and strictly controlled in multiple steps to obtain (3S) -10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid.
What are the physicochemical properties of (3S) -10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2, 3-dihydro-7H- [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid
(3S) -10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H- [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid, this is an organic compound. Its physical and chemical properties are as follows:
From the perspective, it may be a solid at room temperature, but the exact physical form still needs to be determined according to the actual situation. Its melting and boiling point, due to the existence of various chemical bonds and interactions in the molecule, causes complex intermolecular forces, so the melting and boiling point is high. The molecules contain atoms with high electronegativity such as fluorine, oxygen, and nitrogen, which make the molecules have a certain polarity, polarity or affect their solubility. In organic solvents, or due to the principle of similar miscibility, there is a certain solubility in some polar organic solvents, such as ethanol, acetone, etc.; in water, although the carboxyl group can form a hydrogen bond with water, the overall molecular structure may limit its water solubility, so the solubility in water may be limited.
From the theory of chemical properties, its carboxyl group is acidic and can neutralize with bases to form corresponding carboxylates. The lone pair of electrons on the nitrogen atom in the molecule makes it alkaline and can react with acids. In addition, the compound contains multiple unsaturated bonds and heterocyclic structures. These parts have high electron cloud density and nucleophilic properties, which can participate in nucleophilic substitution reactions, nucleophilic addition reactions, etc. The presence of cyclopropyl group, due to the ring tension, makes this part of the chemical activity is high, and it is prone to reactions such as ring opening. At the same time, the conjugate structure of quinoline and oxazine complex ring system affects the molecular stability and reactivity, or participates in special reactions such as photochemical reactions.
(3S) -10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2, 3-dihydro-7H- [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid
(3S) -10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid, which is a new class of quinolones. Looking at its market prospects, there are many things to explore.
In today's pharmaceutical market, there is a constant demand for antimicrobial drugs. Quinolones are very important in the field of anti-infection because of their broad-spectrum antimicrobial activity and good pharmacokinetic properties. ( 3S) -10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid, as a new member, is expected to exhibit better antibacterial activity and lower drug resistance with its unique chemical structure.
From the perspective of research and development, many scientific research institutions and pharmaceutical companies have invested heavily in the research and development of new antibacterial drugs. This compound may be one of the focuses of research and development. With in-depth research, if it can be successfully advanced in pharmacology, toxicology, clinical research, etc., it is very likely to become a new generation of antibacterial sharp weapons.
However, the road to the market is not smooth. The competition of similar drugs is fierce, and many classic quinolones have occupied a large market share. If a new compound wants to stand out, it needs to highlight its advantages in terms of efficacy, safety, and cost-effectiveness. And drug approval regulations are strict, and many regulations and standards need to be met before it can be listed.
In summary, the market prospect of (3S) -10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid is full of opportunities and challenges, and it needs unremitting efforts from all parties to clarify its final market trend.