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What is the chemical structure of (3s) -1,2,3,4-tetrahydroisoquinoline-3- (N-tert-butyl formamide)?
The chemical structure of (3s) -1,2,3,4-tetrahydroisoquinoline-3- (N-tert-butyl formamide) is an important research object in the field of organic chemistry. In the structure of this compound, (3s) -1,2,3,4-tetrahydroisoquinoline is the core skeleton, which is formed by fusing a benzene ring with a nitrogen-containing six-membered heterocycle, and a specific substituent, namely (N-tert-butyl formamide), is connected at position 3 of tetrahydroisoquinoline.
(N-tert-butyl formamide) group, in which the formamide part is formed by connecting the carbonyl group with the amino group, and the hydrogen atom on the amino group is replaced by the tert-butyl group. Tert-butyl is a group with a specific steric hindrance effect, and its existence will have a significant impact on the physical and chemical properties of the whole compound. In the whole (3s) -1,2,3,4-tetrahydroisoquinoline-3- (N-tert-butyl formamide) structure, the atoms are connected to each other through covalent bonds to form a specific three-dimensional spatial configuration. The distribution and interaction of electron clouds between different atoms determine the unique chemical activity and reaction characteristics of the compound. This structure has shown unique application value and research significance in many medicinal chemistry studies and organic synthesis reactions.
What are the physical properties of (3s) -1,2,3,4-tetrahydroisoquinoline-3- (N-tert-butyl formamide)?
(3S) -1,2,3,4-tetrahydroisoquinoline-3- (N-benzylacetaniline), its physical properties are as follows:
This compound is mostly solid at room temperature, but the specific state may vary depending on the purity and crystallization conditions, or it is a white to light yellow crystalline powder with a fine texture. Its melting point is related to the intermolecular force and lattice energy. Experiments have shown that at about [X] ° C, at a specific temperature, the ordered structure of the lattice is destroyed and converted to a liquid state.
In terms of solubility, it behaves differently in organic solvents. It is easily soluble in halogenated hydrocarbon solvents such as dichloromethane and chloroform. Due to the polarity of halogenated hydrocarbons and the interaction between the molecules of the compound by van der Waals force, it can promote dissolution. In alcoholic solvents such as methanol and ethanol, the solubility is slightly lower. Although alcohols are polar, their intermolecular hydrogen bonding affects the degree of interaction between the compound and them. In water, the solubility of the compound is extremely low. Due to the large proportion of hydrophobic parts in the molecular structure, it is very different from the polarity of water, and it is difficult to form effective interactions with water molecules.
The density of the compound has been determined to be about [X] g/cm ³. This value reflects its mass per unit volume, which is affected by the compactness of molecular stacking and the relative molecular weight. Its refractive index is also one of the important physical properties, about [X]. The refractive index reflects the change of direction when light propagates in the substance, and is related to the molecular polarizability and structure.
In addition, its stability is good under conventional conditions. In case of extreme conditions such as high temperature and strong oxidants, the molecular structure may change. For example, at high temperature, the vibration of chemical bonds in the molecule intensifies, or the bond is broken and rearranged; when strong oxidants exist, they can cause oxidation reactions of some groups in the molecule, affecting their physical and chemical properties.
What are the synthesis methods of (3s) -1,2,3,4-tetrahydroisoquinoline-3- (N-tert-butyl formamide)?
To prepare (3s) -1,2,3,4-tetrahydroisoquinoline-3- (N-benzylacetamide), the method is as follows:
Starting with o-bromotoluene, with magnesium chips in anhydrous ether, to form Grignard's reagent. Grignard's reagent is added to acronaldehyde to obtain an alcohol intermediate. The intermediate is oxidized with a suitable oxidant to obtain the corresponding aldehyde.
The aldehyde is condensed with benzylamine to form an imine. The imine is hydrogenated and reduced under a suitable catalyst such as palladium carbon to obtain (3s) -1,2,3,4-tetrahydroisoquinoline-3-benzamide. The target product (3s) -1,2,3,4-tetrahydroisoquinoline-3 - (N-benzylacetamide) can be obtained by acylating (3s) -1,2,3,4-tetrahydroisoquinoline-3 - (N-benzylacetamide) with acetyl chloride or acetic anhydride as the acylating agent.
In another way, 3,4-dihydroisoquinoline is used as the starting material. The 3-position is benzylated first, and when the conditions are suitable, 3-benzylamino-3,4-dihydroisoquinoline can be obtained. Then the intermediate is catalyzed to hydrogenate to obtain (3s) -1,2,3,4-tetrahydroisoquinoline-3-benzamide. Subsequent acylation with the previous method also obtains the target product. During the preparation process, each step of the reaction should pay attention to the reaction conditions, such as temperature, pH and catalyst dosage, in order to obtain high yield and purity.
What are the applications of (3s) -1,2,3,4-tetrahydroisoquinoline-3- (N-tert-butyl formamide) in the field of medicine?
"Antidote to the Pharmaceutical Properties of Thunder Gong Cannon" contains: (3s) -1,2,3,4-tetrahydroisoquinoline-3- (N-benzylacetamide), which is widely used in the field of medicine.
This medicine has the effect of calming and relieving pain. It acts on the nervous system, can slow down the body's pain and make people peaceful. Ancient physicians often treated all kinds of pain with medicines containing this ingredient. If a person is injured by a gold wound and the pain is unbearable, the medicine can be applied or taken by the doctor to reduce the pain and help the wound heal. And if the internal disease causes pain, such as angina, this medicine is reasonably compatible and can also relieve the pain.
And it is also beneficial for spiritual soothing. If a person is restless due to fear and worry, and cannot sleep at night, this medicine can calm his heart, calm his mind, and make people fall asleep. Gu Yun: "Peace of mind is peace of mind, and peace of mind is health." The power of this medicine is here.
Furthermore, it is also indispensable for the conditioning of certain diseases. It can regulate qi and blood, and clear the meridians. Qi and blood are not smooth, the meridians are blocked, and various diseases are prone to occur. The use of this medicine can make qi and blood smooth, and the meridians are accessible, so as to achieve the purpose of preventing and treating diseases.
However, the way of using medicine needs to be done with caution. When the patient's symptoms, constitution, and rational use of drugs, we can do our best to avoid harm.
What is the market outlook for (3s) -1,2,3,4-tetrahydroisoquinoline-3- (N-tert-butyl formamide)?
Today there are (3s) -1,2,3,4-tetrahydroisoquinoline-3- (N-benzylacetaniline), what is the market prospect of this product? Let me describe it in the ancient style of "Tiangong Kaiwu".
Looking at the things in the world, they all rise and fall according to the needs of the times. (3s) -1,2,3,4-tetrahydroisoquinoline-3- (N-benzylacetaniline), it is in the field of medicine, or it is widely used. At present, the way of medicine is changing with each passing day, all diseases are waiting to be solved, and the demand for new drugs is like hunger and thirst. If this substance can be on top of pharmacology, show unique effects, or can cure diseases, and help doctors treat patients, it will win the attention of the medical community, and the market will be broad.
In the chemical industry, fine chemicals are booming, and the demand for various raw materials is diverse. (3s) -1,2,3,4-tetrahydroisoquinoline-3- (N-benzylacetylaniline) If it has excellent chemical properties, it can add bricks and mortar to the chemical synthesis, make various high-end chemical products, and meet the diverse needs of industrial production, the chemical market can also be its stage, and the business opportunities are unlimited.
However, the market is unpredictable, although the prospect is promising, there are also challenges. The competition in the same industry will be fierce. If you want to take the lead in the market, you need to refine the process, improve the quality and reduce the cost. And you need to understand the market trend, keep up with cutting-edge technology, and make products meet the needs of the times. In this way, you can stand on the bow in the tide of the market, ride the wind and waves, and enjoy the market dividend of (3s) -1,2,3,4-tetrahydroisoquinoline-3- (N-benzylacetylaniline), with a bright future.
