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What is the chemical structure of (3R) -1-azabicyclo [2.2.2] octyl-3-yl (1S) -1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid hydrochloride (1:1)?
(3R) -1-aminobicyclo [2.2.2] octyl-3-yl (1S) -1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid ester (1:1) The structure of this compound is composed of two parts.
One of them is (3R) -1-aminobicyclo [2.2.2] octyl-3-yl, which is a nitrogen-containing bilicyclic structure. Bicyclic [2.2.2] octane is used as the parent nucleus, and a substituent is attached to the 3-position carbon according to the R configuration. The two-ring structure has a specific spatial configuration and stereochemical characteristics, and the nitrogen atom occupies a specific position in the ring, which affects the chemical properties and reactivity of the whole molecule.
The second is (1S) -1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid ester, (1S) indicates that the configuration of the 1-position carbon is S-type. The 1-position carbon is linked with a phenyl group to form an aromatic structure, which endows the molecule with certain stability and hydrophobicity. The 3,4-dihydroisoquinoline part is an unsaturated structure with a nitrogen heterocycle, and the 2 (1H) -carboxylic acid ester represents a carboxylic acid ester group attached to the 2-position in the 1H state. The existence of this part of the structure makes the molecule not only have aromatic-related properties, but also have unique reactivity due to carboxylic acid ester groups, which can participate in a variety of organic reactions.
The two combine in a ratio of 1:1 to form a unique chemical structure, and the interaction of each part jointly determines the physical, chemical properties and potential biological activities of the compound.
What are the physical properties of (3R) -1-azabicyclo [2.2.2] octyl-3-yl (1S) -1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid hydrochloride (1:1)?
(3R) - 1 - aminobicyclo [2.2.2] octyl - 3 - group, and (1S) - 1 - naphthyl - 3,4 - dihydroisocoumarin - 2 (1H) - one, mixed in a ratio of 1:1, the physical properties are as follows:
After mixing the two, the appearance may show a specific morphology. (3R) - 1 - aminobicyclo [2.2.2] octyl - 3 - group, with a specific spatial structure, its molecular atomic connection makes the part have a certain stability and chemical activity tendency. ( 1S) -1-naphthyl-3,4-dihydroisocoumarin-2 (1H) -one also has a unique structure. Naphthyl gives it a certain conjugate system characteristics, and dihydroisocoumarin-2 (1H) -one partially determines its chemical properties.
When the two are mixed at 1:1, their melting points may change due to intermolecular interactions. Due to the existence of different functional groups in the two structures, there may be weak interactions with each other, such as van der Waals force, hydrogen bond, etc., resulting in different melting points from the two alone. The boiling point is the same, and the intermolecular forces change, which makes the energy required for gasification different, which in turn affects the boiling point.
In terms of solubility, (3R) -1 -aminobicyclo [2.2.2] octyl-3-yl, and (1S) -1 -naphthyl-3,4 -dihydroisocoumarin-2 (1H) -one, due to the different hydrophilicity of their respective functional groups, the solubility in various solvents after mixing is also characterized. In polar solvents, the polar groups contained in the two or interact with solvent molecules to affect the degree of solubility; in non-polar solvents, the interaction of non-polar parts plays a leading role.
In terms of density, the molecular arrangement and mutual filling after mixing are different from the densities of the two alone, which are caused by the combination of intermolecular space occupation and interaction force in the mixed system. And the optical properties of the mixture, such as refractive index, also have specific effects on light propagation due to molecular structure and interaction.
What is the preparation method of (3R) -1-azabicyclo [2.2.2] octyl-3-yl (1S) -1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid hydrochloride (1:1)?
There are now (3R) -1 -aminobicyclo [2.2.2] octyl-3-yl, and (1S) -1 -naphthyl-3,4 -dihydroisocoumarin-2 (1H) -one, prepared in a ratio of (1:1), as detailed below.
To prepare a mixture of the two in a ratio of 1:1, you can first take an appropriate amount of (3R) -1 -aminobicyclo [2.2.2] octyl-3-based raw materials, which need to be finely purified to remove impurities to maintain their purity. At the same time, an equal amount of properly treated (1S) -1-naphthyl-3,4-dihydroisocoumarin-2 (1H) -one is also taken.
Then, the two are placed in a clean and suitable reaction vessel. The temperature and pressure of the reaction environment need to be precisely controlled, and the temperature should be maintained at a specific range, such as XX degrees Celsius, and the pressure should be stable at XX kPa. At the same time, an appropriate amount of catalyst can be added according to the reaction needs. This catalyst needs to be carefully selected to promote the efficiency and selectivity of the reaction between the two.
During the reaction process, the reaction state needs to be closely monitored, and the progress of the reaction and the formation of the product can be understood by means such as spectral analysis. When the reaction reaches the expected level, the obtained product can be further purified by specific separation and purification methods, such as recrystallization, column chromatography, etc., and the unreacted raw materials and by-products are removed. The final product is (3R) -1 -aminobicyclo [2.2.2] octyl-3-yl, mixed with (1S) -1 -naphthyl-3,4 -dihydroisocoumarin-2 (1H) -one in a (1:1) ratio. The entire preparation process requires considerable care in terms of raw material purity, reaction conditions, and operating skills.
(3R) -1-azabicyclo [2.2.2] octyl-3-yl (1S) -1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid hydrochloride (1:1) What are the application fields?
(3R) -1 -aminobicyclo [2.2.2] octyl-3-yl, and (1S) -1 -naphthyl-3,4 -dihydroisoincense-2 (1H) -ketone (1:1) compounds have applications in many fields.
In the context of pharmaceutical research and development, it may have unique pharmacological activities. Due to the characteristics of (3R) -1 -aminobicyclo [2.2.2] octyl-3-yl structure, it can modify the spatial configuration of drug molecules and enhance the compatibility with specific targets. The (1S) -1-naphthyl-3,4-dihydroisoincense-2 (1H) -ketone part may endow the drug with antioxidant and anti-inflammatory effects. The combination of the two at 1:1 may bring opportunities for the creation of new therapeutic drugs, such as drugs for nervous system diseases and cardiovascular diseases.
In the field of organic synthesis, this compound can be used as a key intermediate. With its special structure, it can construct more complex organic molecules through various organic reactions, such as nucleophilic substitution, addition, etc. Its (3R) -1-aminobicyclo [2.2.2] octyl-3-yl and (1S) -1-naphthyl-3,4-dihydroisoberyl-2 (1H) -keto structural units provide organic synthesis chemists with a wealth of synthetic strategies to help synthesize new functional materials, natural product analogs, etc.
In the field of materials science, this compound may exhibit special optical, electrical or mechanical properties due to its unique molecular structure. ( The conjugated structure of 1S) -1-naphthyl-3,4-dihydroisobean-2 (1H) -one may give the material a certain optical activity, while (3R) -1-aminobicyclo [2.2.2] octyl-3-group can regulate the intermolecular interaction, which is expected to be used in the development of new photoelectric materials, high-performance polymers, etc.
What is the market outlook for (3R) -1-azabicyclo [2.2.2] octyl-3-yl (1S) -1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylate hydrochloride (1:1)?
Nowadays, there are (3R) -1 -aminobicyclo [2.2.2] octyl-3-yl (1S) -1 -naphthyl-3,4 -dihydroisoquinoline-2 (1H) -ketoate in the ratio of (1:1). The market prospect of this product is really the focus of the business community.
This compound has a unique structure and is cleverly connected by aminobicyclo with naphthyl, dihydroisoquinoline ketoate and other parts. The configuration of (3R) and (1S) gives it a specific spatial orientation, or affects its biological activity and chemical properties. The combination of a ratio of (1:1) also suggests that it needs to be precisely controlled in its preparation and application.
In the field of medicine, it may have unique pharmacological activities. The combination of this structure may be compatible with specific biological targets, such as acting on neurotransmitter receptors to regulate nervous system function and bring new opportunities for the treatment of nervous system diseases; it may also affect cell signaling pathways, inhibiting the growth and proliferation of tumor cells, and is expected to be developed into new anti-cancer drugs.
In the chemical industry, it may be used as a ligand for high-efficiency catalysts. With its unique structure, it may play a key role in organic synthesis and improve the yield and purity of the target product by inducing the selectivity and activity of chemical reactions.
However, its market prospects are also facing challenges. The synthesis process may be complex, the cost is high, and large-scale production is restricted. And the research and development of new drugs requires a long cycle and huge investment, and strict clinical trials are required to enter the market.
To sum up, (3R) -1 -aminobicyclo [2.2.2] octyl-3-yl (1S) -1 -naphthyl-3,4 -dihydroisoquinoline-2 (1H) -ketoate (1:1) Although it has potential, it is necessary for scientific research and the business community to join hands to overcome technical problems and explore application methods in order to tap its commercial value.