(3R)-1-azabicyclo[2.2.2]oct-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate butanedioate (1:1)

This is a description of the structure of the chemical substance. (3R) - 1 - aminobicyclo [2.2.2] octyl - 3 - group, (1S) - 1 - naphthyl - 3,4 - dihydroisobean - 2 (1H) - ketosuccinic anhydride (1:1).
(3R) - 1 - aminobicyclo [2.2.2] octyl - 3 - group, " (3R) " indicates the specific chiral configuration of the compound, and this chiral center is at position 3, which is the R configuration. Ammonia heterobicyclic [2.2.2] octyl-3-yl, indicating that it is a nitrogen-containing heterocyclic atom bicyclic structure, this bicyclic skeleton structure is like Tiancheng, just like an ancient treasure, composed of two identical bridge rings, just like the delicate mechanism of heaven and earth creation, and No. 3 is a specific connection check point.
(1S) -1-naphthyl-3,4-dihydroisoincense bean-2 (1H) -keto part, " (1S) " Table No. 1 chiral center is S configuration. 1-Naphthyl, naphthalene is a fused cyclic aromatic hydrocarbon, just like layers of mountains are stacked on top of each other, and this naphthalene group is connected at position 1. 3,4-Dihydro-isocoumarin-2 (1H) -keto, isocoumarin-like structures are hydrogenated and reduced at positions 3,4 to form a dihydro structure, and position 2 is a ketocarbonyl group. 1H indicates the existence of a hydrogen atom at position 1.
Succinic anhydride is combined with the above two in a 1:1 ratio. Succinic anhydride is a cyclic anhydride, like a delicate ring, which is connected to the above structure to form this unique chemical structure. This structure is like a carefully carved treasure in the world. It has the characteristics of various structural units and hi

(3R) -1 -aminobicyclo [2.2.2] octyl-3-yl (1S) -1 -phenyl-3,4 -dihydroisoquinoline-2 (1H) -ketosuccinic acid succinic acid (1:1) This compound has the following physical properties.
In terms of view, this compound is often in a solid state, and its melting point is crucial for discrimination and purity determination. However, due to the special structure of the compound, its melting point is difficult to generalize, and it needs to be accurately determined by experiments.
In terms of solubility, according to its structure, it contains polar and non-polar parts, and may have a certain solubility in organic solvents such as ethanol and dichloromethane. The polar aminobicycle and the carboxyl group part may make it have a good affinity for polar solvents; while the non-polar phenyl group and the dihydroisoquinoline part make it soluble in non-polar organic solvents. However, the solubility in water is limited, because the whole is not a highly hydrophilic structure.
In addition, the compound may have certain stability. In the structure, the aminobicycle and the dihydroisoquinoline skeleton are relatively rigid, which can enhance the stability. However, it contains functional groups such as ketone groups and carboxyl groups. Under specific conditions such as strong acids, strong bases or high temperatures, the reaction may cause structural changes. For example, in alkaline environments, carboxyl groups or form salts; under acidic conditions, ketone groups may participate in reactions such as nucleophilic addition.

(3R) -1-aminobicyclo [2.2.2] octyl-3-yl, and (1S) -1-phenyl-3,4-dihydroisoquinoline-2 (1H) -dimethyl carboxylate (1:1) are widely used.
The combination of the two is of great significance in the development of medicine. In the drug exploration of nervous system diseases, or by virtue of its special structure, it can interact with nerve receptors to regulate nerve transmission, and is expected to become a key component in the treatment of epilepsy, Parkinson's disease and other diseases.
In the field of organic synthesis, it can be used as an extremely important intermediate. Due to their unique structure, they can derive many organic compounds with complex structures and special properties through various chemical reactions, providing a cornerstone for the creation of new materials.
Furthermore, in terms of biological activity research, this composition can help researchers to deeply explore the biochemical reaction mechanism in vivo. By observing its interaction with biological macromolecules, we can gain insight into the mysteries of life processes, and then pave the way for the development of innovative drugs and the advent of new diagnostic and therapeutic methods.

To prepare (3R) -1 -aminobicyclo [2.2.2] octyl-3-yl, and (1S) -1 -phenyl-3,4 -dihydroisoquinoline-2 (1H) -ketosuccinate (1:1), the method is as follows.
First take the relevant raw materials of aminobicyclo, according to specific reaction conditions, such as suitable temperature and pressure, in a suitable solvent, add an appropriate amount of catalyst, initiate the reaction, and gradually construct the molecular structure to obtain (3R) -1 -aminobicyclo [2.2.2] octyl-3-yl intermediate. < Br >
Then with phenyl and other raw materials, the structure of isoquinolinone is constructed through several steps of reaction, and (1S) -1 -phenyl-3,4 -dihydroisoquinoline-2 (1H) -one is obtained.
Then, the above two intermediates are reacted with succinic acid in a specific reaction environment according to a specific molar ratio. When reacting, pay attention to the reaction process, which can be monitored by thin-layer chromatography or other methods. After the reaction is completed, the impurities are removed by separation and purification, such as column chromatography, recrystallization, etc., and finally (3R) -1 -aminobicyclic [2.2.2] octyl-3-yl, and (1S) -1 -phenyl-3,4 -dihydroisoquinoline-2 (1H) -ketosuccinate (1:1) products are obtained. The whole process requires fine control of the reaction conditions at each step to achieve excellent yield and purity.

There are (3R) -1-azabicyclo [2.2.2] octyl-3-yl, and (1S) -1-phenyl-3,4-dihydroisoquinoline-2 (1H) -ketosuccinate (1:1). When storing and using, many matters need to be paid attention to.
This compound is stored at the temperature and humidity of the first environment. Due to high or low temperature and humidity, its properties may change and quality may be affected. It should be placed in a cool, dry place away from direct sunlight to prevent chemical reactions caused by light and deterioration.
Furthermore, the storage place should be well ventilated to avoid mixing with other chemicals to prevent interaction and damage its chemical stability.
As for the use, be sure to strictly follow the operating procedures. Before use, read the relevant instructions carefully and accurately grasp the dosage to prevent improper dosage from causing deviation of experimental results or causing other adverse consequences. During operation, protective measures should also be taken, such as wearing suitable protective equipment to avoid direct contact with the skin and respiratory tract, because the compound may be potentially harmful to the human body. The experimental site should also be equipped with necessary emergency equipment for emergencies. In short, when storing and using this compound, care must be taken to ensure safety and effectiveness.