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3 - Quinolinecarboxylic acid, 1, 2 - dihydro - 1 - (1 - methylethyl) -2 - oxo - what is the chemical structure
Alas! This is a question of chemical structure. 3-Quinoline carboxylic acid, 1,2-dihydro-1- (1-methylethyl) -2-oxygen, has a unique chemical structure.
Looking at this name, it can be seen that its core structure is a quinoline ring. Quinoline is a nitrogen-containing heterocyclic aromatic hydrocarbon, which is fused from a benzene ring and a pyridine ring. In this structure, at the 3rd position of the quinoline ring, there is a carboxyl group, which is one of its important functional groups. The carboxyl group is acidic and can participate in many chemical reactions. < Br >
In addition, 1,2-dihydro means that the double bonds of the 1 and 2 positions of the quinoline ring are hydrogenated to form a single bond. This change makes the electron cloud distribution and reactivity of the ring different. And the 1-bit is connected (1-methylethyl). The existence of this isopropyl has a great impact on the overall properties of the molecule due to steric resistance and electronic effects. Furthermore, the 2-bit is the oxygen generation, that is, there is a carbonyl group. The polarity of the carbonyl group changes the electron cloud density of the surrounding atoms, which affects the stability and reactivity of the molecule.
In summary, the chemical structure of this compound is derived from the quinoline ring, modified by dihydro, substituent and oxygen, forming a unique chemical structure, and the interaction of each part endows it with specific physical and chemical properties.
3 - Quinolinecarboxylic acid, 1, 2 - dihydro - 1 - (1 - methylethyl) -2 - oxo - what are the physical properties
1,2-Dihydro-1- (1-methylethyl) -2-oxo-3-quinoline carboxylic acid, this substance has a variety of physical properties. Its appearance is often in a specific form, mostly crystalline powder, with a white or nearly colorless color and fine texture, which is conducive to identification and processing.
In terms of solubility, its solubility in water is limited, but it can be well dissolved in some organic solvents such as ethanol and acetone. This property is related to the molecular structure, and the molecular polarity determines the difference in solubility. In organic synthesis and drug development, suitable solvents can be selected to help it participate in the reaction or prepare preparations. The melting point of
is also an important physical property. Its melting point is in a specific temperature range. By measuring the melting point, the purity of the substance can be determined. If impurities are mixed in, the melting point will change. For example, in chemical production, accurately knowing the melting point can monitor the purity of the product.
In terms of stability, normal conditions are relatively stable, but in case of strong acid, strong alkali or high temperature, structural changes may occur due to reactions. For example, during storage and transportation, such conditions need to be avoided to ensure the integrity of its chemical structure and maintain its inherent properties and functions.
Density also has unique values. Although it is not intuitive, it affects the mixing and separation of materials in the chemical process. For example, when mixed with other substances, the density difference determines the mixing uniformity and delamination.
3 - Quinolinecarboxylic acid, 1, 2 - dihydro - 1 - (1 - methylethyl) -2 - oxo - what is the main use
1,2-Dihydro-1- (1-methylethyl) -2-oxo-3-quinolinocarboxylic acid, this substance is widely used. In the field of medicine, it is a key intermediate for the synthesis of quinolone antibacterial drugs. Quinolone antibacterial drugs have the characteristics of wide antibacterial spectrum and strong activity, and can effectively inhibit and kill many bacteria. They can be used to treat various infectious diseases in the human body, such as respiratory tract infections, urinary system infections, intestinal infections, etc. With their excellent antibacterial properties, they escort human health.
In the chemical industry, it can be used as a raw material for organic synthesis. With its own specific chemical structure and reactivity, it participates in the synthesis of many organic compounds, laying the foundation for the synthesis of organic materials with special properties and structures, promoting the innovative development of chemical materials, and assisting the research and development of new materials to meet different industrial needs.
In the field of scientific research, as an important chemical reagent for researchers to deeply explore its chemical reaction mechanism and properties. By studying it, it can expand the knowledge boundary of organic chemistry, provide support for the birth of new synthetic methods and theories, promote the continuous development of chemistry, and lead scientific research to new heights.
3 - Quinolinecarboxylic acid, 1, 2 - dihydro - 1 - (1 - methylethyl) -2 - oxo - what are the synthesis methods
The synthesis method of 1,2-dihydro-1- (1-methylethyl) -2-oxo-3-quinoline carboxylic acid, although it is not contained in the classic "Tiangong Kaizi", can now find a chemical synthesis method.
First take a suitable quinoline derivative as the starting material, with its quinoline parent nucleus, which is the key structure. Under specific reaction conditions, organic solvents such as toluene, dichloromethane, etc. are often required to provide the reaction medium and have good solubility.
Add a suitable nucleophilic reagent to the system, and this nucleophilic reagent reacts with the specific check point of the quinoline derivative. In order to promote the reaction, it may be necessary to add alkali substances, such as potassium carbonate, sodium carbonate, etc., to adjust the pH of the reaction system and enhance the activity of nucleophiles.
During the reaction, the temperature and time need to be precisely controlled. Usually warmed to a certain range, such as 50-80 ° C, in this temperature range, the reaction rate and product selectivity can reach a good balance. After several hours to ten hours of reaction, the nucleophilic substitution is fully completed.
Then, the oxidation step is carried out. A suitable oxidizing agent, such as manganese dioxide, potassium dichromate, etc., is often used to oxidize a specific group to construct the 2-oxo structure of the target product. The oxidation reaction conditions also need to be carefully controlled, and the temperature and reaction time are all exquisite to ensure that the degree of oxidation is just right to avoid the structural damage of the product caused by excessive oxidation.
Finally, after separation and purification, column chromatography, recrystallization and other methods are used to remove the residual raw materials, by-products and impurities in the reaction system to obtain pure 1,2-dihydro-1- (1-methylethyl) -2-oxo-3-quinoline carboxylic acid. This series of steps complement each other, and according to chemical principles and experimental techniques, the final synthesis of the target product is achieved.
3 - Quinolinecarboxylic acid, 1, 2 - dihydro - 1 - (1 - methylethyl) -2 - oxo - in which areas is it used
1,2-Dihydro-1- (1-methylethyl) -2-oxo-3-quinoline carboxylic acid, this compound is used in medicine, pesticides and other fields.
In the field of medicine, it is often the key intermediate for the synthesis of quinolones antibacterial drugs. Quinolones effectively hinder bacterial DNA replication, transcription and repair by inhibiting bacterial DNA gyrase or topoisomerase IV, demonstrating powerful antibacterial effects. Classic quinolone antibacterial drugs such as ciprofloxacin and levofloxacin play a cornerstone role in the synthesis process of 1,2-dihydro-1- (1-methylethyl) -2-oxo-3-quinolinocarboxylic acid. Such antibacterial drugs are widely used in clinical practice and have good therapeutic effects on many bacterial infectious diseases such as respiratory tract infections, urinary system infections, and intestinal infections, and escort human health.
In the field of pesticides, some pesticides derived from this compound have unique bactericidal or insecticidal activities. It can achieve the purpose of preventing and controlling pests and diseases by interfering with specific physiological and biochemical processes of pests or pathogens. Such pesticides are of great significance to ensure crop yield and quality in agricultural production, and can help farmers resist the invasion of pests and diseases, protect the thriving growth of crops, and ensure a good harvest.
In summary, although 1,2-dihydro-1- (1-methylethyl) -2-oxo-3-quinoline carboxylic acid is an organic compound, it is used in two important fields of medicine and pesticides. With its unique chemical structure and activity, it plays an indispensable role. It is an important substance to promote human health and agricultural development.
