3-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-8-methyl-, ethyl ester

Ethyl 7-chloro-4-hydroxy-8-methyl-3-quinoline carboxylate is an organic compound. Its main uses are quite extensive, and in the field of medicine, it is often used as an important pharmaceutical intermediate.
Geinoquinoline compounds have various biological activities, such as antibacterial, anti-inflammatory, anti-tumor, etc. With this compound as a starting material, through a series of exquisite chemical reactions, drug molecules with specific pharmacological activities can be constructed. For example, in the development of antibacterial drugs, through ingenious modification and modification of their structures, new antibacterial drugs with high inhibitory activity against specific pathogens can be obtained, providing new and effective means for the treatment of bacterial infections.
In the field of pesticides, 7-chloro-4-hydroxy-8-methyl-3-quinoline carboxylic acid ethyl ester also has important uses. It can be used as a key intermediate in the synthesis of new pesticides, used to create pesticide products with high insecticidal, bactericidal or herbicidal activities. Because of its unique chemical structure, it can give pesticides a unique mechanism of action and performance, which helps to improve the effect of pesticides, while reducing the impact on the environment, in line with the current green agricultural development needs.
In addition, in the field of organic synthetic chemistry, it is an important cornerstone for the construction of complex quinoline derivatives. Chemists can use their special functional groups to synthesize a series of organic compounds with novel structures and unique functions through various organic reactions, such as nucleophilic substitution, oxidation, reduction, etc., providing a rich material basis and research direction for the development of organic synthetic chemistry.

7-Chloro-4-hydroxy-8-methyl-3-quinoline carboxylic acid ethyl ester, this is an organic compound. Looking at its structure, it contains a quinoline ring, and has the substitution of chlorine atoms, hydroxyl groups, methyl groups and ethyl ester groups at specific positions. The following physical properties:
** 1. Appearance and Properties **
Under normal temperature and pressure, it may be a white to light yellow solid powder, which is based on the common appearance of similar quinoline-containing compounds. Due to the intermolecular force, crystal arrangement and other factors, it presents such a aggregated state and color. Similar quinoline derivatives, such as some methyl quinoline carboxylic acid esters, also show this appearance.
** Second, melting point and boiling point **
Melting point, due to the interaction of hydrogen bonds and aromatic rings in the molecule, the molecule is tightly packed, and the melting point may be in a higher range, presumed to be about 150-200 ° C. For example, some quinoline carboxylic acid esters containing chlorine and hydroxyl groups have melting points in this range due to similar structural factors. The boiling point is due to the large molecular weight and the presence of various polar groups, which enhances the intermolecular force. The estimated boiling point is quite high, or at 350-450 ° C. This is consistent with the boiling point of quinoline compounds containing polysubstituents with similar structures. < Br >
** III. Solubility **
In organic solvents, because it has a certain fat-soluble part, such as ethyl ester group and methyl group, it can be soluble in common organic solvents, such as dichloromethane, chloroform, acetone, etc. However, it also contains the polar group of hydroxyl group, which is also very slightly soluble in water. This solubility is similar to that of organic compounds containing similar groups, such as some aromatic compounds containing hydroxyl groups and ester groups, which have such solubility characteristics.
** IV. Density **
Due to its molecular structure containing heavy atom chlorine and the tight structure of the quinoline ring, the density may be greater than that of water, and it is estimated to be 1.3-1.5 g/cm ³, which is equivalent to the density range of chlorine-containing heterocyclic organic compounds.
** 5. Stability **
Under normal environmental conditions, the compound can remain relatively stable if it is protected from light, high temperature and strong acid and alkali. However, due to the presence of hydroxyl groups, it is easy to react in a strongly alkaline environment; chlorine atoms may have substitution reactions under the action of specific nucleophiles. This is all due to the inherent chemical activity of its functional groups, which is consistent with the chemical stability laws of similar compounds containing corresponding functional groups.

There is a method for the synthesis of 7-chloro-4-hydroxy-8-methyl-3-quinoline carboxylic acid ethyl ester. Although it is not detailed in Tiangong Kaiwu, it can be obtained by chemical reasoning.
One method is to use a suitable quinoline derivative as the starting material. Under specific reaction conditions, the methyl group is introduced at the 8th position of the quinoline ring. This step may be achieved by means of alkylation reaction, and a methylating agent with suitable activity, such as iodomethane, reacts with the quinoline derivative under the catalysis of a base to obtain 8-methylquinoline derivative through nucleophilic substitution.
Then, chlorine atoms are introduced at the 7th position. Chlorinated reagents, such as phosphorus oxychloride, can be selected. Under appropriate solvent and temperature conditions, phosphorus oxychloride undergoes an electrophilic substitution reaction with 8-methylquinoline derivatives to introduce chlorine atoms into the 7th position.
Furthermore, the construction of the 4-position hydroxyl group can be achieved. Or it can be achieved by a series of reactions such as hydrolysis and rearrangement. If the original hydrolyzable group at the 4-position is hydrolyzed and then rearranged appropriately, the molecular structure can be adjusted to form a hydroxyl group at the 4-position.
As for the formation of ethyl carboxylate at the 3 position, or based on quinoline derivatives, carboxyl groups are introduced at the 3 position through oxidation reaction, and then esterification reaction occurs with ethanol under acid catalysis to generate ethyl 3-quinoline carboxylate.
Or there may be other methods. The basic framework of the quinoline ring can be constructed first. During the construction process, the required methyl, chlorine, hydroxyl and carboxylate groups are gradually introduced. For example, a few simple organic compounds are used as raw materials to form quinoline rings through cyclization reactions. At the same time, under the precise regulation of the reaction conditions, each group is gradually formed at the target position. Thus, 7-chloro-4-hydroxy-8-methyl-3-quinoline carboxylic acid ethyl ester can be synthesized through a multi-step carefully designed reaction.

7-Chloro-4-hydroxy-8-methyl-3-quinoline carboxylic acid ethyl ester, the price of this product in the market is difficult to say exactly. The price often varies due to many reasons, such as the quality of the quality, the situation of supply and demand, the simplicity of preparation, and the ups and downs of the market.
If the quality is high, the raw materials are rare, the preparation is complicated, and the market is seeking a lot, the supply is scarce, and the price must be high; on the contrary, if the quality is ordinary, the raw materials are easy to obtain, the preparation is simple, and the supply is abundant, there are few applicants, and the price should be low.
However, based on past market conditions and analogy, the price of this product in the market may be between tens of yuan and hundreds of yuan per gram. If the purchase volume is very large, or due to large quantities, the price will be reduced; if the purchase volume is rare, or due to cost factors, the price will be slightly higher. And the pricing of different merchants is also different, or due to different cost accounting and business strategies. To know the exact price, you need to consult each supplier in detail and compare it in many ways to get a more accurate price.

7-Chloro-4-hydroxy-8-methyl-3-quinoline carboxylic acid ethyl ester, the manufacturer of this product, has also explored a lot in the past. However, its production process is complicated and the materials used are exquisite, so there are not many manufacturers who can manage the production.
In China, there are a few manufacturers who are skilled in medicine and chemical industry, and they have studied and produced it. This generation of manufacturers often has profound chemical heritage and has deep attainments in the field of organic synthesis. They explore the delicacy of this compound with a rigorous attitude and advanced equipment.
Some overseas manufacturers are also involved. In Western countries, the chemical industry is developed, and many of them focus on the production of heterocyclic compounds. They rely on cutting-edge technology to innovate the synthesis process of 7-chloro-4-hydroxy-8-methyl-3-quinoline carboxylic acid ethyl ester from time to time.
In the country of the East, its fine chemicals should not be underestimated. Some companies invest in the production of this compound with exquisite skills and strict standards. Strive to achieve the highest quality.
However, due to the relatively small use of 7-chloro-4-hydroxy-8-methyl-3-quinoline carboxylic acid ethyl ester, and the high difficulty of production, the number of manufacturers is limited. It is distributed all over the world, like a star scattered, although there are not many, they are all leaders in the chemical field. With their own expertise, they contribute to the production and development of this compound.