What is the chemical structure of 3-Quinolinecarboxylic acid, 7-chloro-1-cyclopropyl-1, 4-dihydro-8-methyl-4-oxo-, ethyl ester?

This is related to the chemical structure of 7-chloro-1-cyclopropyl-1,4-dihydro-8-methyl-4-oxyquinoline-3-carboxylic acid ethyl ester. This compound belongs to one of the quinolone antibacterial drugs.

In its chemical structure, the quinoline ring is the core structure. At the 3rd position of the quinoline ring, there is an ethyl ester group formed by esterification of the carboxyl group. The existence of this ester group may affect the lipid solubility, absorption and distribution of the compound. The 7-position is a chlorine atom. The introduction of this halogen atom can enhance the affinity of the drug with bacterial DNA rotatase or topoisomerase IV, thereby enhancing the antibacterial activity. The 1-position is linked to cyclopropyl, which can enhance the antibacterial activity of the drug against Gram-positive and negative bacteria. The 4-position is an oxygen atom, which constitutes a carbonyl structure. This carbonyl may play a key role in the interaction between the drug and the target. The methyl group of the 8-position has an impact on the spatial structure and electron cloud distribution of the drug, or is related to the activity and pharmacokinetic properties of the drug.

The various characteristics of this chemical structure make the compound have unique antibacterial properties and pharmacokinetic properties, which are of great value in the field of antibacterial drugs.

What are the physical properties of 3-Quinolinecarboxylic acid, 7-chloro-1-cyclopropyl-1, 4-dihydro-8-methyl-4-oxo-, ethyl ester?

This is 7-chloro-1-cyclopropyl-1,4-dihydro-8-methyl-4-oxyquinoline-3-carboxylic acid ethyl ester, which is a quinolone compound. Its physical properties are as follows:
Viewed, it is often in the state of white-like to light yellow crystalline powder, which is easy to identify and distinguish. The powder is delicate in texture, and sometimes shows a little luster under light, just like fine crystals flickering.
Smell, the substance is almost odorless and has no special odor. This characteristic makes it not uncomfortable to the surrounding environment and users due to strong odor during operation and application.
As for solubility, its solubility in water is quite low, but in some organic solvents, such as dichloromethane, N, N-dimethylformamide, etc., it exhibits a certain solubility. This solubility characteristic is closely related to its molecular structure, and the polar and non-polar parts of the molecule interact together, resulting in different performances in different solvent environments. In non-polar or weakly polar organic solvents such as dichloromethane, molecules and solvents can interact with each other through van der Waals forces to achieve a certain degree of dissolution; while water, as a solvent with strong polarity, interacts weakly with the molecules of the substance, so its solubility is low.
Its melting point is also an important physical property, roughly in a certain temperature range. The determination of the melting point can not only be used to identify the purity of the substance, but also a key characterization of its physical properties. When heated to the melting point, the substance gradually changes from a solid state to a liquid state. This phase change process is of great significance in the identification and quality control of the substance.
In addition, the stability of the substance also needs attention. Under conventional storage conditions, its chemical properties are relatively stable. In case of extreme conditions such as high temperature, strong light, and high humidity, chemical reactions such as decomposition and deterioration may occur. This stability characteristic determines that it needs to be properly protected during storage and transportation to avoid adverse effects of environmental factors on its quality.

What are the common uses of 3-Quinolinecarboxylic acid, 7-chloro-1-cyclopropyl-1, 4-dihydro-8-methyl-4-oxo-, ethyl ester?

This is 7-chloro-1-cyclopropyl-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid ethyl ester, which has a wide range of common uses.

In the field of medicine, it is mostly used as a key intermediate for antibacterial drugs. Antibacterial drugs have significant efficacy on infections caused by many bacteria, and can inhibit bacterial growth and even kill bacteria. The antibacterial drugs made by this compound have a wide range of antibacterial spectrum and are effective on both Gram-positive and Gram-negative bacteria. For example, common Escherichia coli and Staphylococcus aureus infections, drugs made from this intermediate may be effective in coping and helping patients recover.

In the field of organic synthesis, its role should not be underestimated. Due to its specific chemical structure and activity, it can participate in a variety of organic reactions, laying the foundation for the synthesis of more complex and functional organic compounds. Organic synthesis chemists use this to expand the types and structures of compounds, explore the properties and applications of new substances, such as the synthesis of materials with special optical and electrical properties, for cutting-edge fields such as electronics and optics.

Furthermore, in the process of drug development, using this as a starting material or intermediate, through structural modification and optimization, may lead to the development of new antimicrobial drugs with better antimicrobial activity and fewer side effects. Researchers have changed their substituents, adjusted molecular configurations, and other means to explore the interaction mode between compounds and bacterial targets, hoping to obtain more ideal drugs and inject new vitality into the development of medicine.

What are the preparation methods of 3-Quinolinecarboxylic acid, 7-chloro-1-cyclopropyl-1, 4-dihydro-8-methyl-4-oxo-, ethyl ester?

The method of preparing 7-chloro-1-cyclopropyl-1,4-dihydro-8-methyl-4-oxyquinoline-3-carboxylic acid ethyl ester has been around for a long time.

First, it is prepared by multi-step reaction with suitable starting materials. First, take a specific compound containing quinoline structure, which can be properly reacted with chlorinated reagents under specific reaction conditions to obtain 7-chlorinated products. The chlorinated reagent used, or the common sulfoxide chloride, can precisely replace the hydrogen atom at the target position under the action of suitable temperature and catalyst. < Br >
Next, cyclopropyl is introduced. Cyclopropyl halide is often used as a raw material, and under alkaline conditions, nucleophilic substitution reaction occurs with the aforementioned product. The base used, or potassium carbonate, etc., can be successfully reacted in an organic solvent, so that the cyclopropyl is successfully connected to the 1-position of the quinoline ring.

Then, the 8-position is methylated. Methylating reagents, such as iodomethane, can be selected to achieve the introduction of the 8-position methyl group in the presence of suitable bases and catalysts.

As for the formation of the 4-position carbonyl group, it can be achieved by oxidation reaction. Select an appropriate oxidizing agent, such as Jones reagent, etc., in a specific reaction system to oxidize the corresponding alcohol hydroxyl to carbonyl.

Finally, the resulting 7-chloro-1-cyclopropyl-1,4-dihydro-8-methyl-4-oxyquinoline-3-carboxylic acid and ethanol are esterified under the action of concentrated sulfuric acid and other catalysts to obtain 7-chloro-1-cyclopropyl-1,4-dihydro-8-methyl-4-oxyquinoline-3-carboxylic acid ethyl ester.

Second, there are also those prepared in another way. First construct the quinoline ring, select suitable aromatic compounds and nitrogen-containing raw materials, and initially form the quinoline skeleton through condensation reaction. Then proceed to chlorination, cyclopropylation, methylation and carbonylation in sequence. Although the steps are different from the former, they can all achieve the goal. Each step of the reaction needs to pay attention to the precise control of the reaction conditions, such as temperature, reactant ratio, reaction time, etc., so as to make the preparation process smooth and improve the yield and purity of the product.

3-Quinolinecarboxylic acid, 7-chloro-1-cyclopropyl-1, 4-dihydro-8-methyl-4-oxo-, ethyl ester What are the precautions in storage and transportation?

3-Quinoline carboxylic acid, 7-chloro-1-cyclopropyl-1,4-dihydro-8-methyl-4-oxo-ethyl ester, this chemical substance requires careful attention during storage and transportation.

Its properties or specific chemical activities may cause severe reactions in case of heat, open flame, oxidant, etc., and even cause the risk of combustion and explosion. Therefore, the storage place must be kept away from fire and heat sources, and placed in a cool, dry and well-ventilated place. The temperature of the warehouse should be strictly controlled to prevent the material properties from being changed due to excessive temperature.

Furthermore, this compound may be toxic and corrosive, and may damage the skin, eyes and respiratory tract when in contact with the human body. When transporting, be sure to ensure that the packaging is complete and sealed to prevent leakage. Operators need professional protective equipment, such as protective clothing, gloves, protective glasses, etc., to avoid direct contact.

At the same time, this chemical substance may be potentially harmful to the environment. In case of leakage, it should not be discharged at will. It is necessary to properly collect and dispose of the leakage in accordance with relevant regulations to prevent contamination of soil, water sources, etc. During transportation, it is also necessary to prevent accidental leakage into the environment. < Br >
Storage and transportation of 3-quinoline carboxylic acid, 7-chloro-1-cyclopropyl-1,4-dihydro-8-methyl-4-oxo-ethyl ester must be carried out in strict accordance with regulations to ensure personnel safety, environmental safety and material stability in an all-round way.