3-quinolinecarboxaldehyde, 2,8-dichloro-

2 + - + quinoline formaldehyde, 2,8 -dichloro - The chemical properties of this substance are quite important. It has the general properties of aromatic aldodes, and the aldehyde group can cause it to be active and can involve many reactions.
In the oxidation reaction, the aldehyde group can be oxidized to obtain the corresponding carboxylic acid. In case of strong oxidants, such as potassium permanganate, it can be smoothly converted. This is the method of preparing the corresponding carboxylic acid.
Nucleophilic addition reaction is also its characteristic. The carbon-oxygen double bond electron cloud in the aldehyde group is biased towards oxygen, which makes the carbon band partially positively charged and easy to be attacked by nucleophilic reagents. If it is with alcohols, it can form acetals under the catalysis of acids or bases. This reaction is often used as a carbonyl protection method in organic synthesis.
Its halogen atom (2,8-dichloro) is also reactive. Under appropriate conditions, such as nucleophilic substitution, chlorine atoms can be replaced by nucleophilic reagents to expand the structure of compounds and lay the foundation for the synthesis of various derivatives.
Due to the structure of nitrogen-containing heterocyclic quinoline, it has unique electronic effects and spatial structure, which affects the overall properties of molecules, and has potential applications in pharmaceutical chemistry, materials science and other fields. If some compounds with this structure or have biological activity, they can be used as lead compounds for the development and exploration of new drugs. In short, 2,8-dichloro-2-quinolinaldehyde has active chemical properties and diverse reactions, which is of great significance in organic synthesis and related fields.

2+-+quinolinecarboxaldehyde%2C+2%2C8+-+dichloro - that is, 2,8-dichloro-3-quinoline formaldehyde, the main uses of this substance are as follows:
First, in the field of pharmaceutical chemistry, it can be used as a key intermediate. Gai Pharmaceutical Research and Development Changlai specific structural compounds are used as starting materials, and complex drug molecules are constructed through a series of chemical reactions. The unique quinoline and aldehyde structure of 2,8-dichloro-3-quinoline formaldehyde gives it the ability to participate in various reactions and can be derived with specific pharmacological activities. For example, new substances with antibacterial, antiviral and even anti-tumor activities can be constructed by reacting with heteroatomic reagents such as nitrogen and oxygen, paving the way for the creation of new drugs.
Second, it also has important uses in materials science. Due to its structure, the quinoline ring imparts certain rigidity and conjugation properties, and the aldehyde group can participate in the polymerization reaction. Therefore, it can be introduced into the polymer material system to improve the optical and electrical properties of the material. For example, by reasonably designing the reaction, it can be polymerized with other monomers to prepare materials with special luminescent properties, or used in optoelectronic devices such as organic Light Emitting Diodes (OLEDs) to improve the luminous efficiency and stability of the device.
Third, in the field of organic synthesis chemistry, it is an extremely important synthetic block. Organic chemists often use its aldehyde electrophilicity and quinoline ring reactivity to carry out various classical organic reactions, such as the reaction of aldehyde groups with alcohols to form acetals, or the condensation reaction with amines to form Schiff bases. Through these reactions, more complex and functional organic molecular structures can be built, the types and properties of organic compounds can be expanded, and the development of organic synthetic chemistry can be promoted.

There are currently methods for the synthesis of 2,8-dichloro-3-quinoline formaldehyde, which are described below.
First take the appropriate quinoline derivative as the starting material. The structure of this raw material should contain a check point that can be substituted and modified to prepare for the subsequent introduction of chlorine atoms and aldehyde groups.
In a specific reaction vessel, add an appropriate amount of organic solvent, such as dichloromethane or N, N-dimethylformamide, to create a suitable reaction environment, so that the reactants can be evenly dispersed and fully contacted.
Place the quinoline derivative in it, and slowly add chlorinated reagents, such as phosphorus oxychloride and phosphorus pentachloride. The reaction needs to be started at a low temperature environment, preferably about 0 ° C to 5 ° C, in order to precisely control the reaction process and avoid excessive chlorination. As the reaction proceeds, gradually heat up to room temperature, and continue to stir, so that the chlorine atoms can be successfully replaced at the 2nd and 8th positions of the quinoline ring to form 2,8-dichloroquinoline derivatives. In this process, the progress of the reaction needs to be closely monitored by thin-layer chromatography (TLC). When the raw material point disappears, the chlorination reaction is completed.
Then, the aldehyde-based reaction of 2,8-dichloroquinoline derivatives is carried out. Select a suitable aldehyde-based reagent, such as urotropine, and add it to the reaction system in a certain proportion. The reaction temperature needs to be raised to 100 ° C to 120 ° C to allow the reaction to fully occur under reflux conditions. At this stage, urotropine interacts with 2,8-dichloroquinoline derivatives and introduces an aldehyde group at position 3.
After the reaction is completed, the system is cooled and treated with an appropriate acid-base treatment, such as washing with a dilute hydrochloric acid solution, to remove unreacted urotropine and its decomposition products. The product is then extracted with an organic solvent, the organic phase is collected, dried with anhydrous sodium sulfate, and the solvent is removed by rotary evaporation. The obtained crude product is further purified by column chromatography. Silica gel is used as the fixed phase, and the mixture of petroleum ether and ethyl acetate is used as the mobile phase. According to the difference in the partition coefficient between the product and the impurities in the stationary phase and the mobile phase, the separation is The fractions containing the target product were carefully collected and the mobile phase was removed by rotary evaporation to obtain a pure 2,8-dichloro-3-quinoline formaldehyde.

I don't know what the price of "3+-+quinolinecarboxaldehyde%2C+2%2C8+-+dichloro -" is in the market. This is a rather professional chemical substance, and its price fluctuates, often depending on multiple factors.
First, the price of raw materials. If the raw materials required to make this substance are scarce or expensive, the price of the finished product is also high. Second, the difficulty of preparation. If the preparation process requires exquisite skills, harsh conditions, or takes a long time, the price will also rise. Third, market supply and demand. If there are many people who want it, and there are few people who supply it, the price will rise; conversely, if the supply exceeds the demand, the price may fall.
And the price of this substance varies with different purity and specifications. The higher the purity, the more expensive it is. Furthermore, the amount of purchase also affects the price, and there may be discounts for bulk purchases.
However, it is difficult for me to determine the price range, because the market is unpredictable and I do not know the latest market conditions. For details, you can consult chemical reagent suppliers, or visit chemical product trading platforms, where accurate price ranges may be available.

2 + - + quinoline formaldehyde, 2,8 -dichloro - The method of storing this material is quite important. Cover these chemical substances, and they are very active. If they are not hidden in the right way, there may be deterioration, damage to the effect, or even risk of danger.
When hiding, the first priority is the environment. It is advisable to choose a cool place to avoid all kinds of heat. Cover heat can promote its molecular activity to intensify, causing its chemical properties to change easily. And it must be dry to prevent moisture from invading. If moisture enters, or causes various reactions such as hydrolysis, it will damage its original properties.
Furthermore, the choice of container is also the key. When using a well-sealed container, either glass or plastic can be used, and it must be ensured that it does not merge with the hidden object. The key to sealing is to prevent air from entering, because oxygen, water vapor, etc. in the air can react with the object.
In addition, this object may be toxic, irritating, etc., so the place where it is hidden should be far away from the place where humans and animals often go, and its name and characteristics should be clearly marked to prevent accidental touch and misuse. And when there is a special person in charge, it should be checked frequently to see if there are any abnormal changes. In this way, it can be stored for a long time without changing its properties, so that it can be used later without fear.