3-methyl-8-Quinolinesulfonyl chloride

3-Methyl-8-quinoline sulfonyl chloride, this is an organic compound. Its chemical properties are unique and of considerable research value.
Looking at its structure, it contains a quinoline ring, which endows the compound with certain stability and special electronic effects. The quinoline ring is a dense heterocyclic system, in which nitrogen atoms have a great influence on the electron cloud distribution of the molecule. The methyl group at the 3-position, because it is the power supply group, can change the electron cloud density of the quinoline ring, so that the electron cloud density of the ortho and para-position is relatively increased, which affects the reactivity of the compound. The sulfonyl chloride group at the 8-position, -SO 2O Cl, is highly reactive.
In terms of chemical properties, sulfonyl chloride groups are active and easily hydrolyzed in water to form corresponding sulfonic acids and hydrogen chloride. This hydrolysis reaction is a nucleophilic substitution process. Water acts as a nucleophilic reagent to attack the sulfur atoms in the sulfonyl chloride group, and the chlorine atoms leave. The compound can react with alcohols to form sulfonates. The hydroxyl oxygen atom in the alcohol acts as a nucleophilic reagent to attack the sulfur atoms of the sulfonyl chloride, and the chloride ions leave to form sulfonate esters. It can also react with amine compounds. The nitrogen atom in the amine has strong nucleophilicity and attacks the sulfonyl chloride group to form sulfonamide products. Due to its special chemical properties, 3-methyl-8-quinoline sulfonyl chloride is widely used in the field of organic synthesis. It can be used as an important intermediate to construct compounds containing special functional groups, providing an important material basis for drug synthesis, materials science and many other fields.

3-Methyl-8-quinoline sulfonyl chloride is a crucial chemical reagent in organic synthesis. It has a wide range of uses and is commonly found in the following fields.
In the field of medicinal chemistry, this reagent can be used as a key intermediate. The synthesis of many drugs often relies on its construction of specific molecular structures. For example, some heterocyclic compounds with special pharmacological activities can precisely introduce specific functional groups through the reaction of 3-methyl-8-quinoline sulfonyl chloride, which in turn endows the drug with unique properties, such as enhancing the affinity between the drug and the target, improving the efficacy and selectivity of the drug, etc. < Br >
In the field of materials science, it also has outstanding performance. For example, in the preparation of functional polymer materials, 3-methyl-8-quinoline sulfonyl chloride can be used as a reactive monomer to polymerize with other monomers, thereby introducing quinoline sulfonyl groups into the polymer chain. The introduction of this group can significantly change the electrical, optical or thermal properties of polymer materials, making it suitable for the preparation of various advanced materials such as organic Light Emitting Diodes and sensors.
Furthermore, in the field of dye chemistry, 3-methyl-8-quinoline sulfonyl chloride also plays an important role. By reacting with different aromatic amines or phenolic compounds, a series of novel dyes can be synthesized. Due to the conjugated structure of the quinoline ring and the reactivity of the sulfonyl chloride group, these dyes exhibit excellent dyeing properties, such as high color fastness and bright color light, and are widely used in textile, printing and other industries.
In summary, 3-methyl-8-quinoline sulfonyl chloride plays an indispensable role in many fields such as medicine, materials and dyes, and promotes the continuous development of scientific research and industrial production in related fields.

The synthesis of 3-methyl-8-quinoline sulfonyl chloride is a key research topic in the field of organic synthesis. Its synthesis path requires multiple steps of delicate chemical reactions to achieve.
The first step is often to use quinoline as the starting material. Quinoline is introduced into the methyl group at its third position through a specific substitution reaction. This process requires the selection of a suitable methylation reagent, such as iodomethane, and the appropriate reaction conditions. This reaction condition covers factors such as reaction temperature, reaction time, and the catalyst used. Generally speaking, the reaction temperature may be controlled in a specific range, such as between 50 and 80 degrees Celsius, and it needs to be carried out in an alkaline environment with a suitable base, such as potassium carbonate, to assist the reaction. In this way, 3-methylquinoline can be obtained.
The next step is to further convert 3-methylquinoline into 3-methyl-8-quinoline sulfonic acid. This step usually uses fuming sulfuric acid as a sulfonation reagent and reacts at a higher temperature, about 150-200 degrees Celsius. In this reaction, the concentration, dosage and reaction time of fuming sulfuric acid all have a significant impact on the effectiveness of the reaction. After this reaction, the sulfonic acid group was successfully introduced into 8 positions.
In the last step, 3-methyl-8-quinoline sulfonic acid reacts with chlorinated reagents such as thionyl chloride or phosphorus oxychloride to obtain 3-methyl-8-quinoline sulfonyl chloride. This reaction is usually carried out under the condition of heating and reflux, and an appropriate amount of catalyst, such as DMF, is often added to accelerate the reaction process. After the reaction, a series of post-processing operations, such as distillation, extraction, recrystallization, etc., are used to purify the product to obtain high-purity 3-methyl-8-quinoline sulfonyl chloride. In this way, the synthesis of 3-methyl-8-quinoline sulfonyl chloride is finally achieved through various fine steps.

3-Methyl-8-quinolinesulfonyl chloride is a chemical substance. When storing and transporting, many matters must be paid attention to.
It is active and easy to react with substances containing active hydrogen such as water and alcohol. Therefore, when storing, it must be placed in a dry place, away from water sources, to avoid its hydrolysis and deterioration. The storage container used should also be tightly closed to prevent moisture from invading.
And because of its corrosive nature, it is irritating to human skin, eyes and respiratory tract. When storing, keep it separate from flammable, explosive and other chemicals to prevent dangerous interaction. At the same time, the temperature of the storage environment should not be too high, and it should be stored in a cool place, usually 2-8 ° C, which can ensure the stability of its chemical properties.
As for transportation, it must be in accordance with relevant regulations and standards. The transportation container must be solid and durable, and have good sealing and leak-proof properties. During the handling process, the operator should wear appropriate protective equipment, such as protective gloves, goggles and protective clothing, to prevent contact injuries.
Furthermore, it should not be mixed with food, medicine, etc. during transportation to avoid contamination. The transportation vehicle should also be equipped with emergency treatment equipment and materials. In case of unexpected situations such as leakage, it can be properly disposed of in time to reduce harm. Therefore, it is necessary to ensure the safety of 3-methyl-8-quinoline sulfonyl chloride during storage and transportation to avoid accidents.

What you are asking about is the market price range of 3-methyl-8-quinoline sulfonyl chloride. However, "Tiangong Kaiwu" involves mostly the skills and products of agricultural and industrial industries, and does not match the price of this chemical. In today's world, the price of chemical substances often varies due to many reasons, such as differences in origin, quality, supply and demand, and market conditions.
In the chemical raw material market, the price of this 3-methyl-8-quinoline sulfonyl chloride may vary due to purity. If the purity is high and the preparation is excellent, the price may be high; if the purity is slightly inferior, the price should be slightly lower. And if there are many manufacturers and sufficient supply, the price may stabilize and drop slightly; if raw materials are scarce and production is limited, resulting in tight supply, the price will rise easily.
Generally speaking, the price range is difficult to determine. In general chemical transactions, or hundreds to thousands of yuan per kilogram. However, this is only a rough guess. If you want to know the details, you should consult chemical raw material suppliers, traders, or check the real-time quotation of chemical product trading platforms to get a close price range.