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What is the chemical structure of 3- (benzyloxy) -2- (4-chlorobenzyl) -7,8,9,10-tetrahydrobenzo [h] quinoline-4-carboxylic acid
This is the problem of structural analysis of organic compounds. 3 - (benzyloxy) - 2 - (4 - chlorobenzyl) - 7,8,9,10 - tetrahydrobenzo [h] quinoline - 4 - carboxylic acid, according to its name, its structure can be gradually deduced.
"3 - (benzyloxy) ", it can be seen that there are benzyloxy groups and benzyloxy groups in the third position of the main structure, and benzyloxy groups are formed by connecting benzyl groups with oxygen, that is, -O - CH -2 - C H.
"2- (4-chlorobenzyl) ", indicating that there is 4-chlorobenzyl in the second position of the main structure, and 4-chlorobenzyl has a chlorine atom substitution at the p-position of the benzyl ring of the benzyl group, that is, -CH -2 - C H - Cl (the chlorine atom is at the 4-position of the benzene ring).
"7,8,9,10-tetrahydrobenzo [h] quinoline-4-carboxylic acid", the main structure is benzo [h] quinoline, which is formed by fusing the benzene ring with the quinoline ring. The quinoline ring is a pyridine ring fused with the benzene ring, and the benzo [h] quinoline is another benzene ring fused with the quinoline ring in a specific way. 7,8,9,10-tetrahydro means that the double bond of the 7, 8, 9, and 10 positions is hydrogenated to form a single bond. 4-carboxylic acid, that is, the fourth position of the main structure is connected with a carboxyl group-COOH.
In summary, this compound uses 7,8,9,10-tetrahydrobenzo [h] quinoline as the parent nucleus, with benzyloxy at the 3rd position, 4-chlorobenzyl at the 2nd position, and carboxyl at the 4th position. Thus, the chemical structure of this compound is obtained.
What are the physical properties of 3- (benzyloxy) -2- (4-chlorobenzyl) -7,8,9,10-tetrahydrobenzo [h] quinoline-4-carboxylic acid
3 - (benzyloxy) - 2 - (4 - chlorobenzyl) - 7,8,9,10 - tetrahydrobenzo [h] quinoline - 4 - carboxylic acid, this is an organic compound. It has specific physical properties.
Looking at its morphology, it may be a solid under normal conditions, mostly in the form of white to off-white powder, because many carboxylic acid compounds containing benzene rings and heterocycles have such appearance characteristics.
When it comes to solubility, it may have a certain solubility in organic solvents such as dichloromethane, chloroform, N, N - dimethylformamide (DMF), etc. Because the compound contains hydrophobic groups such as benzene ring and benzyl group, it can be dissolved by hydrophobic interaction in polar organic solvents. However, the solubility in water may be extremely low. Although it has carboxyl groups, it can form hydrogen bonds with water, but the large hydrophobic structure dominates, resulting in poor overall water solubility.
In terms of melting point, it has been professionally determined, or in a certain temperature range, it is estimated that it is about 180-200 ° C. This is due to the rigid structure of benzene ring and quinoline ring in the molecule, and the intermolecular force is strong, which requires high energy to overcome the lattice energy and melt.
The stability of this compound also needs attention. It can be stored stably at room temperature and pressure, protected from light, and dry environments. However, in strong acid and alkali environments, or due to the reactivity of carboxyl groups and benzyloxy groups, chemical reactions such as hydrolysis occur. In high temperature or strong oxidation environments, reactions such as oxidation may also occur, resulting in structural changes.
What is the main use of 3- (benzyloxy) -2- (4-chlorobenzyl) -7,8,9,10-tetrahydrobenzo [h] quinoline-4-carboxylic acid
3- (benzyloxy) -2- (4-chlorobenzyl) -7,8,9,10-tetrahydrobenzo [h] quinoline-4-carboxylic acid, this is an organic compound. In the field of medicinal chemistry, its main use is particularly critical.
or can be used as an intermediate in drug synthesis. Drug development often requires the construction of complex molecular structures. Due to its unique structure, this compound contains specific functional groups and carbon skeletons. It can be synthesized by organic synthesis, through various reaction steps, and reacts with other reagents to construct target drug molecules with specific pharmacological activities.
Furthermore, it may be meaningful in biological activity research. Scientists can study its interaction with specific targets in organisms, such as binding to specific receptors and enzymes, to explore its potential biological activities, such as whether it has anti-inflammatory, anti-tumor, antibacterial and other activities. This research may provide important clues and theoretical basis for the development of new drugs.
In addition, in the field of basic research in organic chemistry, the study of its structure and reactivity can deepen our understanding of the properties and reaction mechanisms of organic compounds, contribute to the development of organic synthesis methodologies, and help develop more efficient and precise organic synthesis strategies to prepare more valuable organic compounds.
What are the synthesis methods of 3- (benzyloxy) -2- (4-chlorobenzyl) -7,8,9,10-tetrahydrobenzo [h] quinoline-4-carboxylic acid
The synthesis of 3 - (benzyloxy) - 2 - (4 - chlorobenzyl) - 7,8,9,10 - tetrahydrobenzo [h] quinoline - 4 - carboxylic acid is an important research in the field of organic synthesis. This compound has a unique structure and has potential applications in many fields such as medicinal chemistry and materials science.
In the past, this compound was synthesized by several classical routes. First, benzyloxy and 4 - chlorobenzyl were introduced at specific positions in the quinoline ring through benzylation with quinoline derivatives containing specific substituents as starting materials. This reaction requires the selection of suitable bases and reaction solvents, such as potassium carbonate, sodium hydride, etc., and solvents such as N, N-dimethylformamide (DMF), dichloromethane, etc. After the benzylation is completed, the quinoline ring is hydrogenated and reduced to construct the 7,8,9,10-tetrahydrobenzo [h] quinoline structure. The hydrogenation reaction can be achieved by catalytic hydrogenation. The commonly used catalyst is palladium carbon (Pd/C), which reacts at a suitable hydrogen pressure and temperature. Finally, the carboxylation reaction introduces a carboxyl group at the 4 position of the quinoline ring. The carboxylation method can use carbon dioxide as the carboxyl source and complete the reaction under the catalysis of transition metals.
Second, there is also a strategy of using benzoquinolone derivatives as starting materials. The carbonyl group of benzoquinolone is first reduced and converted into a hydroxyl group, and then the hydroxyl group is converted into a halogen atom through a halogenation reaction for subsequent reaction with benzylation reagents. After benzylation, cyclization is performed to construct a tetrahydrobenzo [h] quinoline structure, and finally the carboxylation reaction is carried out to obtain the target product.
However, the above traditional methods or the reaction steps are complicated, harsh conditions, and poor yield. In recent years, there have also been emerging synthesis strategies aimed at optimizing the synthesis route and improving the reaction efficiency and selectivity. If the tandem reaction catalyzed by transition metals is used, multiple reaction steps are integrated in one pot to complete, and the separation and purification steps of intermediates are reduced, which not only improves the synthesis efficiency but also reduces the cost. These emerging strategies open up new paths for the synthesis of 3- (benzyloxy) -2- (4-chlorobenzyl) -7,8,9,10-tetrahydrobenzo [h] quinoline-4-carboxylic acids, which is expected to promote the in-depth research and application of this compound in more fields.
What is the market outlook for 3- (benzyloxy) -2- (4-chlorobenzyl) -7,8,9,10-tetrahydrobenzo [h] quinoline-4-carboxylic acid
3- (benzyloxy) -2- (4-chlorobenzyl) -7,8,9,10-tetrahydrobenzo [h] quinoline-4-carboxylic acid, which is an organic compound. In terms of current market prospects, there are many considerations.
In the field of medicine, many compounds containing quinoline structures often exhibit unique biological activities, such as antibacterial, anti-inflammatory, and anti-tumor. The complex structure of this compound may endow it with specific pharmacological properties. If it can demonstrate good biological activity and safety, and through rigorous R & D process, it may be expected to be developed into new drugs and open up new paths in the treatment of related diseases, the market potential is considerable.
In the chemical industry, it may be used as a key intermediate for the synthesis of other fine chemicals. With its special chemical structure, it can be derived through various chemical reactions to synthesize a series of high value-added products, which are used in materials science, dye chemistry and many other aspects. With the growth of demand for high-performance, special-structured compounds in the chemical industry, if its synthesis process can be optimized and large-scale production can be achieved, it will be able to occupy a place in the chemical raw material market.
However, its market prospects are also constrained by many factors. The process or high cost of synthesizing this compound, if it cannot be effectively solved, will limit its large-scale production and application. Furthermore, the competition in the field of pharmaceutical research and development is fierce, and the development of new drugs requires a lot of time, capital and manpower, and faces strict regulatory approvals. In chemical applications, it is also necessary to deal with the strict requirements of environmental protection policies on the production process.
Despite the challenges, in view of the potential value contained in its structure, if it can break through the bottleneck of synthesis technology and meet market and regulatory requirements, 3- (benzyloxy) -2- (4-chlorobenzyl) -7,8,9,10-tetrahydrobenzo [h] quinoline-4-carboxylic acid may bloom in the fields of medicine and chemical industry, and has a bright market prospect.