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What is the chemical structure of 7-dimethoxy-1-veratrylisoquinoline hydrochloride?
This is 3,4-dihydro-6,7-dimethoxy-1-veratrol isoquinoline hydrochloride, and its chemical structure is quite complex. The compound belongs to the isoquinoline class, and the basic structure of isoquinoline is a nitrogen-containing heterocyclic ring. On this basis, a dihydro group is added at positions 3 and 4, which is obtained by double bond hydrogenation. At positions 6 and 7, a methoxy group is attached, that is, an OCH group. The presence of a methoxy group can significantly affect the physical and chemical properties of the compound, such as solubility, electron cloud distribution, etc. 1-Position linked veratrol, veratrol usually refers to 3,4-dimethoxybenzyl, which is composed of a benzene ring connecting two methoxy groups and a methylene group. The whole compound is in the form of hydrochloride, which means that it forms a salt with hydrochloric acid. Through acid-base reaction, nitrogen atoms combine hydrogen ions to form a salt, which can not only change its solubility, but also enhance its stability in some cases. The unique chemical structure of this compound may endow it with specific biological activities and uses, which may have important research value in the fields of medicinal chemistry and organic synthesis.
What are the physical properties of 3,4-Dihydro-6, 7-dimethoxy-1-veratrylisoquinoline hydrochloride?
3% 2C4-dihydro-6% 2C7-dimethoxy-1-veratrol isoquinoline hydrochloride, this is an organic compound. Its physical properties are as follows:
The appearance is mostly powdery, delicate and uniform in texture. The color may be white, pure and white; or slightly yellowish, like light dyeing over time, which is caused by the presence of impurities or subtle differences in the synthesis process.
Solubility is quite important. In water, its solubility may be limited. Water is the source of life, so this compound is difficult to stretch to its fullest, only slightly soluble, and seems to maintain a reserve in water. However, in organic solvents such as ethanol and chloroform, it exhibits good solubility, just like a wanderer returning home, and can closely blend with organic solvents, uniformly disperse, and form a stable solution.
Melting point is also a key characteristic. After precise determination, its melting point is within a specific range, and this temperature is like the unique imprint of the compound. When it reaches this temperature, the solid compound is like ice and snow meeting the warm sun, gradually melting into a liquid state, and embarking on a different form journey. This melting point range is not only a sign of its physical characteristics, but also of great significance in the identification and purity judgment of compounds.
In terms of stability, under conventional environmental conditions, this compound can remain relatively stable, like a stable old man, and is not easily disturbed by the outside world. In the event of high temperature, strong light or specific chemical substances, it will quietly change, or undergo chemical reactions, or decompose and deteriorate, and its stability will be challenged under specific conditions.
3% 2C4-dihydro-6% 2C7-dimethoxy-1-veratrol isoquinoline hydrochloride The physical properties lay the foundation for its research and application in the field of chemistry, and also provide guidance for exploring more of its mysteries.
What are the main uses of 7-dimethoxy-1-veratrylisoquinoline hydrochloride?
3% 2C4-dihydro-6% 2C7-dimethoxy-1-veratrol isoquinoline hydrochloride, which is mostly found in the field of pharmaceutical and chemical industry. In organic synthesis, it is often used as a key intermediate to assist in the formation of many complex organic compounds. In pharmaceutical research and development, due to specific chemical structures and biological activities, or it is very useful in the creation of new drugs, it is the cornerstone for exploring new therapeutic targets and drug action mechanisms.
The chemical synthesis of the view can be obtained through multiple reaction paths. During the synthesis process, the reaction conditions are extremely controlled, which is related to the purity and yield of the product. In the hands of organic synthesis craftsmen, using this as a starting material, through delicate reaction design and optimization of conditions, organic molecules with complex structures and specific functions can be constructed, just like skilled craftsmen build a mansion with masonry.
On the road of medical exploration, researchers have investigated the interaction between it and biomacromolecules, hoping that it can open a new path for conquering difficult diseases. Or it can adjust specific biological signaling pathways and show unique advantages for the treatment of certain diseases. Although the application prospect is broad, it must be used in accordance with norms and safety guidelines to ensure its safe and effective application in various fields.
What are the synthesis methods of 3,4-Dihydro-6, 7-dimethoxy-1-veratrylisoquinoline hydrochloride?
To prepare 3% 2C4-dihydro-6% 2C7-dimethoxy-1-veratrol isoquinoline hydrochloride, there are many methods, each has its own strengths, and the current Chen number method is as follows.
First, veratrol and phenethylamine are used as starting materials. First, veratrol and phenethylamine are condensed to obtain an imine intermediate. This step requires selecting a suitable solvent, such as ethanol, etc., and controlling the temperature and time to make the reaction sufficient. Later, a reducing agent, such as sodium borohydride, is used to reduce the imine to an amine, and the key intermediate can be obtained. Then the intermediate is cyclized, under acidic conditions, such as hydrochloric acid, to promote cyclization, and then generate a free base of the target product, and finally form a salt with hydrochloric acid to obtain 3% 2C4-dihydro-6% 2C7-dimethoxy-1-veratrol isoquinoline hydrochloride.
Second, start from 3,4-dimethoxyphenylacetonitrile. First, alkylate 3,4-dimethoxyphenylacetonitrile and introduce veratrol. This process requires the selection of suitable bases, such as sodium hydride, and appropriate halogenated veratrol, and react in an anhydrous environment. The alkylation product is reduced to an amine group by a method such as Raney nickel catalytic hydrogenation, and then cyclized within the molecule to construct an isoquinoline skeleton. The subsequent salt formation steps are similar to the previous method, and the target product can also be obtained.
Third, the Pictet-Spengler reaction can be used. With 3,4-dimethoxyphenethylamine and an aldehyde derived from veratrol as the substrate, under the catalysis of acid, such as p-toluenesulfonic acid, the condensation and cyclization reaction occurs to directly construct the isoquinoline structure. After the reaction, the reaction is treated, and the salt is formed, and the final product is 3% 2C4-dihydro-6% 2C7-dimethoxy-1-veratrol isoquinoline hydrochloride. All kinds of methods vary depending on factors such as raw materials, conditions, and yield. When operating, we should consider carefully and choose the most suitable method.
What are the precautions for the use of 3,4-Dihydro-6, 7-dimethoxy-1-veratrylisoquinoline hydrochloride?
3% 2C4-dihydro-6% 2C7-dimethoxy-1-veratrol isoquinoline hydrochloride. When using this product, many matters need to be paid attention to.
The first priority is safety, which is fundamental. Because of its specific chemical activity, it must be fully protected when contacting. Wear chemically resistant gloves with both hands to prevent the agent from being contaminated, eroding the skin, causing allergies and burns. Protective masks should be worn on the face to protect the eyes and eyes to avoid it entering the eyes, damaging the eye tissue and causing eye diseases. The operating space must be well ventilated. If it is in a closed place, the volatile gas of the agent will accumulate, or cause respiratory discomfort, or even risk poisoning.
Furthermore, it is related to the operation specification. When the amount used is accurately measured, according to the needs of the experiment or production, it should be measured with scientific measuring tools, not more or less. More is a waste of resources, and may cause excessive reaction; less is difficult to achieve the desired effect. When dissolving, choose the appropriate solvent, pay attention to the dissolution temperature and duration. If the temperature is too high or the agent is decomposed and deteriorated; if the duration is insufficient, the dissolution is not complete, which also affects the follow-up process.
The method of storage should not be ignored. It should be stored in a cool, dry place, away from fire sources and oxidants. If the environment is humid, the agent absorbs moisture, or causes changes in properties; near the fire source, there is a risk of explosion; in case of oxidants, or a violent reaction, damage the agent and endanger safety.
After the operation is completed, clean it properly. The utensils used should be washed with suitable solvents, and the residual agents should be disposed of according to regulations. Do not dump them at will to avoid polluting the environment and harming the ecology.
All these are things that should be kept in mind and implemented when using 3% 2C4-dihydro-6% 2C7-dimethoxy-1-veratrol isoquinoline hydrochloride. In this way, it is safe, effective, and safe to use.