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What is the chemical structure of 2- (Tert-Butoxycarbonyl) -1,2,3, 4-Tetrahydroisoquinoline-6-Carbonic Acid?
2 -% 28Tert - Butoxycarbonyl% 29 - 1% 2C2% 2C3% 2C4 - Tetrahydroisoquinoline - 6 - Carbonic Acid is 2 - (tert-butoxycarbonyl) - 1,2,3,4 - tetrahydroisoquinoline - 6 - carboxylic acid. Its chemical structure is as follows:
The core structure of this compound is isoquinoline, which is a heterocyclic system with two fused phenyl rings and nitrogen atoms. In this compound, the 1,2,3,4 positions of isoquinoline are hydrogenated to form a 1,2,3,4 - tetrahydroisoquinoline structure. < Br >
At the 2-position, tert-butoxycarbonyl (-COO-t-Bu) is connected. Tert-butoxycarbonyl is a common protective group and is often used to protect amino or carboxyl groups in organic synthesis. In its structure, the carbonyl group (C = O) is connected to the 2-position of the isoquinoline ring, and the other side of the carbonyl group is connected to tert-butyl (-t-Bu). Tert-butyl has a large steric resistance.
At the 6-position, it is connected to a carboxyl group (-COOH), which makes the compound acidic. The whole molecular structure combines the backbone of tetrahydroisoquinoline and the substituents at specific positions, which endow the compound with unique chemical properties and reactivity, and have potential application value in the fields of organic synthesis and medicinal chemistry. It can be used as an intermediate to construct more complex molecular structures with biological activity.
What are the main uses of 2- (Tert-Butoxycarbonyl) -1,2,3, 4-Tetrahydroisoquinoline-6-Carbonic Acid?
2 - (tert-butoxycarbonyl) - 1, 2, 3, 4 - tetrahydroisoquinoline - 6 - carboxylic acid, this is an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis, just like the cornerstone of building a delicate castle.
In the field of pharmaceutical chemistry, with its unique chemical structure, it may be used to create new drugs. In the process of many drug development, the structural unit of this compound has been ingeniously modified and modified, which is expected to give birth to drugs with excellent efficacy and mild side effects. For example, the construction of some molecules with specific biological activities may rely on the initiation of this compound, and different groups are added through gradual reactions to shape the structure that fits the drug target.
In the field of materials science, it also has its place. It can participate in the preparation of materials with special properties, such as optical materials, polymer materials, etc. With its structural properties, it is endowed with unique physical or chemical properties, such as improving the stability and solubility of materials, which is like injecting magic power into materials and making them suitable for multiple scenarios.
In addition, in academic research, it serves as a model compound to help researchers delve into basic chemical problems such as reaction mechanism and structure-activity relationship. It is like a key to open the door of chemical mysteries, leading researchers to step into the hall of deeper knowledge and contributing to the development of the chemical field.
What are the synthesis methods of 2- (Tert-Butoxycarbonyl) -1,2,3, 4-Tetrahydroisoquinoline-6-Carbonic Acid?
To prepare 2 - (tert-butoxycarbonyl) -1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid, there are various methods. First, the isoquinoline ring system can be constructed by multi-step reaction from suitable starting materials, and then the tert-butoxycarbonyl and carboxyl groups can be introduced. For example, starting with phenethylamine compounds with suitable substituents, the isoquinoline skeleton is first cyclized to form an isoquinoline skeleton, or by Friedländer condensation reaction, the o-aminobenzaldehyde is condensed with the corresponding carbonyl compound to obtain the isoquinoline structure. Subsequently, through a suitable protecting group strategy, tert-butoxycarbonyl is introduced with reagents such as tert-butyl alcohol and di-tert-butyl dicarbonate, which can effectively protect specific functional groups in subsequent reactions. The introduction of carboxyl groups can be achieved by reacting with carbon dioxide by Grignard reagents, or by cyanylation of halogenated hydrocarbons, and then hydrolysis.
Second, compounds with partial target structures can be used as starting materials. For example, if there are isoquinoline rings containing convertible functional groups at specific positions, tert-butoxycarbonyl and carboxyl groups can be introduced in sequence through functional group conversion. During operation, attention should be paid to the choice of reaction conditions, such as temperature, solvent, catalyst, etc., which have a great impact on the progress of the reaction and the selectivity of the product. If the temperature is too high or too low, side reactions may occur or the reaction rate is poor; the polarity and solubility of the solvent are related to the dispersion and reactivity of the reactants; suitable catalysts can significantly improve the reaction efficiency and selectivity. And after each step of the reaction, appropriate separation and purification methods, such as column chromatography, recrystallization, etc. are required to obtain high-purity intermediate products and final products to ensure the feasibility of the synthesis route and the quality of the product.
What are the physicochemical properties of 2- (Tert-Butoxycarbonyl) -1,2,3, 4-Tetrahydroisoquinoline-6-Carbonic Acid?
2-%28Tert-Butoxycarbonyl%29-1%2C2%2C3%2C4-Tetrahydroisoquinoline-6-Carbonic + Acid is 2- (tert-butoxycarbonyl) -1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid. The physical and chemical properties of this compound are quite important, let me tell you in detail.
Looking at its physical properties, it may be a solid state at room temperature and pressure. Because of its structure, it contains specific groups or has a certain melting point. However, the specific melting point value needs to be determined by precise experiments. Its appearance may be white to off-white powder, which is a common appearance of many organic compounds with similar structures.
As for chemical properties, tert-butoxycarbonyl (Boc) in this compound is active. Under suitable conditions, such as acidic environments, Boc is prone to deprotection reactions to form corresponding amine compounds. This reaction is very critical in the field of organic synthesis and is often an important step in the construction of complex molecular structures. The carboxylic group in the molecule has typical carboxylic acid properties and can neutralize with bases to form carboxylic salts. In case of alcohols, under the action of catalysts, esterification reactions can occur to form corresponding ester compounds. And because its molecule contains tetrahydroisoquinoline structure, has certain aromatic and conjugated systems, it can participate in various electrophilic and nucleophilic substitution reactions under specific conditions, showing rich chemical reactivity.
2- (tert-butoxy carbonyl) -1,2,3,4-tetrahydroisoquinoline-6-carboxylic acids have rich and diverse physical and chemical properties, and have crucial applications in organic synthesis, medicinal chemistry and other fields.
2- (Tert-Butoxycarbonyl) -1, 2, 3, 4-Tetrahydroisoquinoline-6-Carbonic Acid What is the price range in the market?
I look at your question, but I am inquiring about the price range of 2- (tert-butoxycarbonyl) -1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid in the market. However, the price of this drug varies depending on market conditions, quality, purchase quantity, sellers and other factors, and it is difficult to determine the exact number.
If it is in the chemical raw material market, its price may range from tens of yuan to more than 100 yuan per gram. If it is a high-purity product for scientific research, the price may be higher, up to several hundred yuan per gram. The larger the purchase quantity, the lower the price per gram may be, or there may be a batch discount.
And the market in different regions varies due to differences in supply and demand. Prosperous commercial ports or due to competition, the price is slightly lower; remote places or due to logistics costs, the price is slightly higher.
The qualifications and brand reputation of re-sellers are also related to the price. Products produced by well-known pharmaceutical companies, although the price is high, are of high quality and purity, and there are many believers.
If you want to know the exact price, you need to consult chemical reagent suppliers, pharmaceutical companies or check on relevant trading platforms to get a price range close to the actual price.