2-Quinolinecarboxylicacid, 4,6-dichloro-, methyl ester

The physical properties of 2-hydroxybenzoic acid, 4,6-dinitro, and toluene are as follows:
2-hydroxybenzoic acid, also known as salicylic acid, is a white fine needle-like crystalline or crystalline powder. It tastes slightly sweet and then turns symplectic. It is stable in the air, but gradually changes to a light red when exposed to light. The melting point is 158-161 ° C, and the boiling point is about 211 ° C (2.67kPa). It is easily soluble in ethanol, ether, and chloroform. It is slightly soluble in water and dissolves in boiling water. Its molecules contain carboxyl groups and phenolic hydroxyl groups, so they are acidic and can react with bases to form salts.
4,6-dinitro-2-hydroxybenzoic acid, usually a yellow crystalline solid. The melting point is high, up to about 217-220 ° C. Due to the introduction of two nitro groups into the molecule, its stability is lower than that of salicylic acid. The strong electron-absorbing properties of the nitro group reduce the electron cloud density of the benzene ring and enhance the acidity of the carboxyl group. It has limited solubility in organic solvents and very little solubility in water.
Toluene, a colorless clear liquid, has a benzene-like odor. Melting point - 94.9 ° C, boiling point 110.6 ° C. Insoluble in water, miscible in most organic solvents such as benzene, alcohol, and ether. Toluene is volatile, and the vapor is heavier than air. It can spread to a considerable distance at a lower place. In case of open flame and high heat, it can cause combustion and explosion. Its chemical properties are relatively stable, but under certain conditions, such as light or the presence of a catalyst, methyl can undergo substitution reaction, and benzene ring can also undergo electrophilic substitution reaction.

2-% pentenoic acid, 4,6-dihydroxy-, methyl ether, is a genus of organic compounds. Its chemical properties are unique and it has attracted much attention in the field of organic synthesis.
This compound has the general properties of enoic acids. If it is ethylenically bonded, it is also an electron-rich functional group, so it can be added to electrophilic reagents. In the case of hydrogen halide, the halogen atom can be added to the carbon containing less hydrogen in the ethylenically bond, and the hydrogen is added to the carbon containing more hydrogen, in accordance with the Markov rule. It can also be added with halogen elementals, such as bromine, at room temperature to fade the bromine water. This is a common method for testing the ethylenically bond.
Carboxyl group is also an important functional group. It is acidic and can neutralize with bases to form corresponding carboxylic salts and water. And it can react with alcohols under acid catalysis and esterification to form esters and water.
And the structure of 4,6-dihydroxy-gives it special properties. Hydroxyl groups can participate in many reactions, such as reacting with active metals such as sodium to release hydrogen. It can also dehydrate under appropriate conditions to form ethers or olefins. In addition, the adjacent and para-position of phenolic hydroxyl groups are affected by the effect of hydroxyl groups, and the electron cloud density increases, which is easy to replace with electrophilic reagents.
The part of methyl ether is relatively stable, but under certain conditions, such as strong acid or high temperature, ether bonds can be broken, replaced or other transformations occur.
2-% pentenoic acid, 4,6-dihydroxy-, methyl ether, due to the interaction of functional groups, presents a variety of chemical properties, and has potential application value in many fields such as drug synthesis and material preparation.

To prepare 2-pentanoic acid, 4,6-dihydroxy-, methyl ester, you can follow the following ancient method.
First take glutaric anhydride, with an appropriate amount of alcohol, such as methanol, and place it in the reaction kettle with the catalyst. This catalyst can be selected from sulfuric acid or the like, which can promote the esterification reaction between glutaric anhydride and methanol. The temperature is controlled at a suitable degree, about 60 to 80 degrees Celsius, and after several hours of stirring, the glutaric anhydride gradually converts to glutaric acid monomethyl ester. The reason for this reaction is that the acid anhydride and the alcohol meet the catalyst, the hydroxyl group in the alcohol attacks the carbonyl carbon of the acid anhydride, the anhydride bond is broken, and the ester and carboxylic acid are < Br >
times, take monomethyl glutarate and mix it with an appropriate amount of alkali solution, such as sodium hydroxide solution. The base can deprotonate the carbonyl α-hydrogen of monomethyl glutarate to generate carboanion. This carboanion is nucleophilic and can undergo nucleophilic addition reaction with suitable aldodes, such as formaldehyde. The temperature is controlled near room temperature. After the reaction is completed, a carboxylic acid ester intermediate containing hydroxyl groups is obtained.
Furthermore, this intermediate is co-placed with a dehydrating agent. The dehydrating agent can be selected from concentrated sulfuric acid, etc. Under heating conditions, at about 120 to 140 degrees Celsius, the hydroxyl group and the hydrogen on the adjacent carbon dehydrate a molecule of water to form a carbon-carbon double bond, and finally obtain 2-pentenoic acid, 4,6-dihydroxy-, methyl ester. In this process, concentrated sulfuric acid strips the hydroxyl group and hydrogen, and forms a double bond by eliminating the reaction.
To make this compound, the conditions of each step of the reaction are very critical. The temperature, the ratio of reactants and the reaction time all need to be accurate to make the yield good and the product pure.

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Its nature may be dangerous, and the storage place must be dry and well ventilated. If it is in a humid place, or due to water vapor erosion, its properties change, cause chemical reactions, damage its quality, and even risk safety. Poor ventilation, the accumulation of harmful gases, endangering the surrounding environment and personal safety.
The control of temperature and humidity is also crucial. If the temperature is too high, or the activity of the substance is enhanced, the reaction is intensified, and there is a risk of fire and explosion; if the temperature is too low, it may solidify and crystallize, affecting subsequent use. The humidity should also be appropriate. If the humidity is too large, it is easy to cause deliquescence; if the humidity is too small, it may be dry and cracked.
Furthermore, the storage place should be kept away from fire sources, heat sources and oxidants. This substance is very easy to explode when exposed to open flames and hot topics; in contact with oxidants, it is easy to react violently and cause serious consequences.
When transporting, the packaging must be strong and tight. Ensure that there is no leakage to prevent the packaging from being damaged due to bumps and collisions during transportation, leaking harmful substances, polluting the environment, and endangering the safety of others.
The means of transportation should also be suitable. Those with corresponding safety protection facilities should be selected, and the transporters must be professionally trained and familiar with the characteristics of the substance and emergency treatment methods. Transportation route planning can not be ignored, to avoid water sources, densely populated areas and other sensitive areas, in order to reduce the risk of leakage.
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