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2 - Quinolinecarboxylic acid, 4 - hydroxy - 3 - methyl -, ethyl ester what are the chemical properties
4-Hydroxy-3-methyl-2-quinoline carboxylic acid ethyl ester, this is an organic compound. Its chemical properties are particularly important, and are described as follows:
####1. Physical properties are related
This compound is mostly in a solid state at room temperature, but the specific melting point will change due to factors such as purity. Its appearance is often white to off-white crystalline powder, soluble in specific organic solvents. For example, in some polar organic solvents, such as ethanol and acetone, it exhibits a certain solubility. However, its solubility in water is poor, because the molecular structure contains hydrophobic quinoline ring and other groups, which greatly limits its interaction with water molecules.
###Second, chemical stability
1. ** Thermal stability **: Under moderate heating conditions, it still has a certain stability. However, when the temperature rises to a higher degree, the molecular structure is divided into chemical bonds or rearrangements such as fracture and rearrangement occur. For example, the quinoline ring structure may undergo changes such as ring opening, because high temperature can provide enough energy to break the chemical bonds that maintain the molecular structure.
2. ** Acid-base stability **: In an acidic environment, the hydroxyl groups, ester groups and other functional groups in its molecular structure may react. Like ester groups will hydrolyze under acidic conditions and gradually convert into corresponding carboxylic acids and alcohols. In an alkaline environment, the compound is more reactive. The ester group is easily hydrolyzed under alkaline conditions to form carboxylic salts and alcohols. In addition, alkaline conditions may also affect the substituents on the quinoline ring, causing the substituents to undergo nucleophilic substitution and other reactions.
3. ** Redox stability **: The hydroxyl group in this compound has certain reductivity, and under the action of strong oxidants, the hydroxyl group is easily oxidized. For example, when reacted with strong oxidants such as potassium permanganate, the hydroxyl group can be oxidized to aldehyde or carboxyl groups. At the same time, if there are suitable reducing agents in the system, some unsaturated bonds in the molecule (such as double bonds on the quinoline ring) may be able to undergo reduction reactions.
###III. Functional group reaction characteristics
1. ** Hydroxy reaction **: As a reactive functional group, the hydroxyl group can participate in many reactions. It can acylate with acyl chloride, acid anhydride, etc. to form corresponding ester derivatives. In addition, the hydroxyl group can also undergo a substitution reaction under appropriate conditions and be replaced by other groups.
2. ** Ester reaction **: In addition to the hydrolysis reaction mentioned above, the ester group can also participate in the transesterification reaction. In the presence of a specific catalyst, transesterification occurs with other alcohols to generate new esters and alcohols, whereby the molecular structure can be modified to obtain compounds with different properties.
3. ** Quinoline ring reaction **: The quinoline ring can undergo electrophilic substitution reaction due to its aromaticity and unsaturation. For example, under appropriate conditions, a halogen atom is introduced into the quinoline ring by reacting with a halogenating agent. Moreover, the methyl group on the side chain of the quinoline ring can also undergo some reactions, such as the oxidation of the methyl group to a carboxyl group under the action of a suitable oxidizing agent.
2 - Quinolinecarboxylic acid, 4 - hydroxy - 3 - methyl -, ethyl ester what is the common synthesis method
To prepare ethyl 4-hydroxy-3-methyl-2-quinoline carboxylate, the common synthesis method is as follows.
First, it can be achieved by a multi-step reaction from a suitable starting material. Start with an aromatic compound with a specific structure, and make it condensate with a nitrogen-containing reagent under suitable reaction conditions. This condensation reaction requires precise regulation of the reaction temperature, reaction time and the proportion of reactants. For example, an aromatic derivative and a specific nitrogen-containing compound are placed in an organic solvent, heated and in an environment with a catalyst, and condensed to construct the basic skeleton of the quinoline ring. < Br >
Then, the obtained quinoline ring product is functionally modified. For the introduction of methyl groups at the 3-position, an appropriate methylating agent can be selected to react in an alkaline environment. The strength and reaction time of alkalinity are crucial. If the alkalinity is too strong or the reaction time is too long, it may cause increased side reactions. The formation of 4-hydroxyl groups can be achieved through specific hydrolysis or substitution reactions. The hydrolysis reaction requires the selection of appropriate hydrolysis reagents and reaction conditions to ensure the precise introduction of hydroxyl groups into the target position.
As for the ethylation of the 2-carboxyl group, ethanol and appropriate esterification reagents are commonly used. For example, under acid catalysis, the carboxyl group is esterified with ethanol to obtain 4-hydroxy-3-methyl-2-quinoline carboxylic acid ethyl ester. In this process, the type and dosage of acid, reaction temperature and time will all affect the yield and purity of the esterification reaction.
Second, there are also ways to use other compounds as starting materials and undergo multi-step transformation. Intermediates containing key functional groups are first synthesized, and then the structure of the target product is gradually constructed through a series of reactions such as cyclization and functional group transformation. This process also requires careful control of the reaction conditions at each step to ensure that the reaction proceeds in the desired direction to obtain ethyl 4-hydroxy-3-methyl-2-quinoline carboxylate with higher yield and purity.
2 - Quinolinecarboxylic acid, 4 - hydroxy - 3 - methyl -, ethyl ester in which applications
Ethyl 4-hydroxy-3-methyl-2-quinolinocarboxylate is widely used. In the field of medicine, it is a key intermediate for the synthesis of many drugs. The structure of geinoquinoline is common in many bioactive compounds. This substance can be modified by specific chemical reactions to prepare drugs with antibacterial, anti-inflammatory, anti-tumor and other effects.
In the field of materials science, or can be used to develop materials with special properties. Due to its molecular structure endowing it with certain unique physical and chemical properties, it can be used to prepare optical materials with absorption or emission properties for specific wavelengths of light, or exhibit unique electrical properties under specific conditions, making a difference in the field of electronic devices.
In the field of organic synthesis, as an important intermediate, it provides the starting structure for the synthesis of complex organic compounds. With its structural characteristics, it can construct more complex and diverse organic molecular structures through a series of organic reactions, such as nucleophilic substitution, oxidation reduction, etc., which helps organic synthesis chemists to expand the compound library and develop new functional organic materials. In short, ethyl 4-hydroxy-3-methyl-2-quinoline carboxylate has important application value in many fields such as medicine, materials science, and organic synthesis, providing a key material basis for the development of many fields.
What is the market price of 2 - Quinolinecarboxylic acid, 4 - hydroxy - 3 - methyl -, ethyl ester
4-Hydroxy-3-methyl-2-quinoline carboxylic acid ethyl ester, this is an organic compound. In ancient books like Tiangong Kaiwu, there is no record of its market price, because there is no concept of such compounds in the era of writing. However, in today's chemical market, its prices fluctuate frequently, which is influenced by many factors.
First, the price fluctuations of raw materials have a great impact. If the price of the basic raw materials required for the synthesis of this compound, such as specific quinoline derivatives, alcohols, acids, etc., rises, the cost of the product will increase, and the price will increase. Second, the complexity of the production process is closely related to the cost. If fine and cumbersome reaction steps, special catalysts or harsh reaction conditions are required, the production cost is high and the price is also high. Third, the market supply and demand relationship is the key factor. If the demand for pharmaceuticals, pesticides and other fields increases greatly, but the supply is limited, the price will inevitably rise; on the contrary, if the market is saturated and the supply exceeds demand, the price will fall.
In terms of the general situation of the current chemical raw material market, such special organic synthesis intermediates have different purity and obvious price differences. Low-purity products, per kilogram or hundreds of yuan; high-purity products, such as for pharmaceutical research and development, can reach tens of yuan or even more per gram, depending on the actual market conditions.
2 - Quinolinecarboxylic acid, 4 - hydroxy - 3 - methyl -, ethyl ester what is the safety and toxicity
4-Hydroxy-3-methyl-2-quinoline carboxylate ethyl ester, this substance is related to safety and toxicity, and its details are crucial.
From the safety end, this compound may have specific chemical activities. In its structure, quinoline ring, hydroxyl group, methyl group interact with ethyl ester group, or affect its stability and reactivity. In the conventional storage state, if the ambient temperature and humidity are suitable and the seal is properly sealed, it can be maintained relatively stable. In case of hot topic, open flame or strong oxidant, it may trigger a chemical reaction and cause the risk of explosion. Furthermore, in the industrial process, if the operation does not follow the specifications, it will cause leakage, or pollute the surrounding environment, it needs to be properly protected and controlled.
As for toxicity, its chemical structure suggests potential harm. Hydroxyl groups are connected to the quinoline ring, or affect biological activity. Animal experiments and past studies may reveal that oral ingestion, inhalation or skin contact may damage the health of the body. Or irritate the skin and mucous membranes, causing redness, swelling and pain. If it enters the respiratory system, it may cause respiratory discomfort, cough and other diseases. Long-term exposure may involve the liver, kidneys and other organs, affecting their normal function. However, the exact toxicity depends on professional experimental determination, taking into account many factors such as dose, exposure duration and body differences.
In summary, the safety and toxicity of 4-hydroxy-3-methyl-2-quinoline carboxylic acid ethyl ester need to be strictly reviewed, and the operation and disposal must strictly abide by the procedures and do a good job of protection to ensure safety.
