2-Methoxy-4-bromoquinoline

2-Methoxy-4-bromoquinoline is an organic compound with specific physical properties. Its properties are often off-white to light yellow crystalline powders, which appear in this way because of its molecular structure and crystal arrangement. In terms of solubility, the substance is slightly soluble in water. This is because water is a polar solvent, while the polarity of 2-methoxy-4-bromoquinoline molecules is relatively weak. According to the principle of "similar miscibility", its solubility in water is low. However, it is soluble in organic solvents such as dichloromethane, chloroform, and ethanol. In non-polar or weakly polar organic solvents such as dichloromethane and chloroform, 2-methoxy-4-bromoquinoline molecules can interact with solvent molecules through van der Waals force, so they can be dissolved. In ethanol, although ethanol has a certain polarity, it also contains a non-polar alkyl group, which can form an intermolecular force with 2-methoxy-4-bromoquinoline to promote dissolution.
Its melting point is in a specific range, about between [X] ° C and [X] ° C. The melting point is affected by intermolecular forces. There are interactions such as van der Waals forces and hydrogen bonds between 2-methoxy-4-bromoquinoline molecules. Specific energy is required to overcome these forces to cause lattice disintegration, thus presenting this melting point range. The boiling point is about [X] ° C, and the boiling point is related to the intermolecular forces and the relative molecular weight. The relative molecular mass is large, and the intermolecular forces are strong. A higher temperature is required for the molecules to obtain enough energy to overcome the interaction and escape the liquid phase to reach the boiling point.
The density of 2-methoxy-4-bromoquinoline is about [X] g/cm ³, and this density is determined by its molecular weight and the degree of molecular packing compactness. When the molecular mass is constant, the concentration of molecules in the crystal structure is different, resulting in different weights per unit volume, resulting in the density value. These physical properties are of great significance for their applications in organic synthesis, drug development and other fields, and provide a basis for the selection of related operations and reaction conditions.

To prepare 2-methoxy-4-bromoquinoline, there are several common synthesis methods as follows.
First, 4-bromoquinoline is used as the starting material and can be obtained by methoxylation. First, 4-bromoquinoline is placed in an appropriate solvent, such as N, N-dimethylformamide (DMF), and a base such as potassium carbonate is added as an acid binding agent, and then iodomethane is slowly added dropwise. This reaction is carried out under heating conditions at a temperature of about 60-80 ° C for several hours. The alkali can induce the nitrogen atom of 4-bromoquinoline to form negative ions, and then undergo nucleophilic substitution reaction with iodomethane to form 2-methoxy-4-bromoquinoline. The reaction mechanism is clear, the operation is relatively simple, and the yield is also considerable.
Second, start from 2-hydroxy-4-bromoquinoline. Mix 2-hydroxy-4-bromoquinoline with dimethyl sulfate, use sodium hydroxide solution as alkali, and react in organic solvent toluene. Dimethyl sulfate is used as a methylation reagent. Under the action of alkali, its methyl group is combined with the hydroxyl oxygen atom of 2-hydroxy-4-bromoquinoline to complete methoxylation. The reaction temperature is controlled at 50-70 ° C, and the stirring is continued for several hours. The raw material of this route, 2-hydroxy-4-bromoquinoline, is relatively easy to obtain, and the reaction conditions are mild, which is suitable for laboratory preparation.
Third, the strategy of Ullmann reaction is adopted. 4-bromo-2-haloquinoline (such as 4-bromo-2-chloroquinoline) is used as the reactant with sodium methoxide. Under the catalysis of copper powder or copper salt (such as cuprous iodide), the reaction is heated in a high boiling point solvent (such as 1,2-dimethoxyethane). The copper catalyst promotes the coupling of the halogen atom with the methoxy group in sodium methoxide to form the target product. Although the choice of catalyst and the reaction conditions need to be carefully regulated, this method is also an effective method for the synthesis of 2-methoxy-4-bromoquinoline by constructing C-O bonds.

2-Methoxy-4-bromoquinoline is useful in many fields. In the field of medicinal chemistry, this compound is often a key intermediary. Due to its unique chemical structure, it can be derived from various bioactive substances through various chemical reactions. Or it can be used to create new antimicrobial drugs, which may be in line with key targets in microorganisms to block the metabolic pathways of bacteria and achieve antibacterial effect; or it has emerged in the development of anti-tumor drugs, inhibiting the proliferation and spread of tumor cells by interfering with specific signaling pathways of tumor cells.
In the field of materials science, 2-methoxy-4-bromoquinoline has also attracted much attention. It can participate in the synthesis of organic optoelectronic materials. Materials made from this raw material may have special optical and electrical properties, and may improve their photoelectric conversion efficiency and stability in organic Light Emitting Diodes (OLEDs), solar cells and other devices. The structure of the compound can adjust the electron cloud distribution of the material, which in turn affects its characteristics of light absorption and emission, as well as its ability to transport charge.
In the field of organic synthetic chemistry, this compound is an important building block. Chemists can modify its structure through various classical organic reactions, such as nucleophilic substitution, metal-catalyzed coupling reactions, etc., to construct more complex and functional organic molecules. The position of the methoxy group and bromine atom provides a unique check point for the reaction, which can precisely guide the synthesis of the target product, help organic synthesis chemists to achieve the construction of complex molecules, and then expand the variety and function of organic compounds.

2-Methoxy-4-bromoquinoline, the price of this product in the market is difficult to determine. The change in its price is influenced by various factors.
The first to bear the brunt is the difficulty of preparation. The steps in synthesizing this compound may be complicated or simple, and the materials used may be easy or difficult, all of which are related to cost. If the preparation method is complicated, rare raw materials are required, or the conditions are strict, the cost will be high, and the price will be high.
Furthermore, the trend of supply and demand is the key. If the market has strong demand for this product and the supply is limited, the so-called "rare is expensive", its price will rise; on the contrary, if the demand is small and the supply is abundant, the price will decline.
In addition, the difference between manufacturers also affects the price. Different manufacturers have different costs due to their technical level, production scale, and management efficiency. Large factories rely on the benefits of scale, the cost may be low, and the price may be more accessible to the people; small factories are the opposite.
If you want to know the exact market price, you can get a more accurate price by consulting chemical raw material suppliers, chemical trading platforms, or at relevant industry exhibitions and seminars. However, the market is fickle, and prices can change at any time. Therefore, when inquiring about prices, you should also pay attention to changes in the market.

2-Methoxy-4-bromoquinoline is one of the organic compounds. The storage conditions of this compound are crucial to the stability and quality preservation of this compound.
This compound should be stored in a cool, dry and well-ventilated place. In a cool place, it can be avoided from decomposition or deterioration caused by high temperature. High temperature can promote the acceleration of chemical reactions, causing the structure of this compound to change and damage its inherent characteristics. Generally speaking, the temperature should not exceed 30 ° C.
Dry environment is also indispensable. Wet gas can cause many chemical reactions, or cause hydrolysis and other changes, affecting the purity and quality of 2-methoxy-4-bromoquinoline. Therefore, in the storage place, when trying to dehumidify, it can be assisted by desiccant to keep the environment dry.
Well ventilated to avoid the accumulation of harmful gases. If the storage space is closed, the volatile gas of the compound may react with the air components, and in case of leakage, ventilation can quickly disperse harmful substances and reduce their harm.
Furthermore, 2-methoxy-4-bromoquinoline should be kept away from fires and heat sources. This is flammable or potentially flammable. In case of open flames, hot topics, it is dangerous to burn or even explode. When storing, it also needs to be separated from oxidizing agents, acids, and alkalis. Because of its active chemical properties, contact with them can easily cause chemical reactions and lead to safety accidents.
Storage containers should also be selected carefully. Sealed containers should be used to prevent their volatilization from contacting external substances. Glass or specific plastic containers should be selected according to the specific properties of the compound to ensure that the container does not interact with the compound and does not affect its quality.
In this way, the above storage conditions can be followed to maintain good quality and stability of 2-methoxy-4-bromoquinoline during storage.