2(H)-quinoline-,7-bromo

The chemical structure of 2% 28H% 29 -quinoline -, 7 -bromo is: there is a hydrogen atom at position 2 of the quinoline ring, and a bromine atom is introduced at position 7.
Quinoline is an organic compound containing nitrogen heterocyclic. Its structure is formed by fusing a benzene ring with a pyridine ring. In this compound, the substituent at a specific position gives it unique chemical properties. The hydrogen atom at position 2, although seemingly ordinary, has an impact on the electron cloud distribution and reactivity of the molecule. Bromine atoms are introduced at position 7. As a halogen element, bromine has strong electronegativity. Its existence changes the electron cloud density on the quinoline ring, making it more prone to nucleophilic substitution and other reactions. Compounds with this structure are often used as key intermediates in the field of organic synthesis to construct more complex organic molecular structures. For example, by activating hydrogen at position 2, it can react with other functional groups to achieve molecular derivatization; bromine atoms at position 7 can also participate in various coupling reactions, expand the carbon chain of molecules or connect different functional groups, which has important application value in pharmaceutical chemistry, materials science and other fields.

2% 28H% 29 -quinoline -, 7 -bromo is 7 -bromo-2 (1H) -quinoline, which has the following main physical and chemical properties:
Viewed at room temperature, it is mostly in the state of off-white to light yellow crystalline powder. Its melting point is between 138-142 ° C. This characteristic causes the substance to undergo phase transition in a specific temperature range, which has a great impact on its heating, storage and other operations. In terms of solubility, it is slightly soluble in water, but easily soluble in organic solvents such as dichloromethane, ethanol, and acetone. In organic solvents, it can be well dispersed and dissolved. This property is crucial in its extraction, separation and participation in organic reactions. Organic solvents can be used as reaction media to help the reaction occur smoothly.
In terms of chemical properties, the molecular structure contains quinoline rings and bromine atoms, so the chemical activity is highlighted. Quinoline rings are aromatic and can undergo electrophilic substitution reactions, while bromine atoms, as active functional groups, can participate in a variety of nucleophilic substitution reactions. For example, when reacting with nucleophiles containing nitrogen, oxygen, sulfur, etc., new carbon-heteroatomic bonds can be formed to synthesize a series of derivatives, which is of great significance in the field of medicinal chemistry. Many drug molecular designs often use such reactions to introduce specific functional groups to optimize pharmacological activities. In addition, its stability needs to be carefully considered under specific conditions. When exposed to strong oxidizing agents, strong acids and bases, the molecular structure may be damaged, and reactions such as oxidation and hydrolysis may occur. Therefore, it is necessary to avoid such chemical environments during storage and use.

2% 28H% 29-quinoline -, 7-bromo is 7-bromo-2 (H) -quinoline, which is commonly used in many organic synthesis reactions.
In halogenation reactions, due to the activity of bromine atoms in the structure, 7-bromo-2 (H) -quinoline can be used as a halogenation reagent to participate in the reaction of introducing bromine atoms to specific compounds. In this process, bromine atoms will be substituted at specific positions based on the reaction conditions and the characteristics of the substrate to achieve the purpose of constructing novel carbon-bromine bonds, paving the way for subsequent derivatization reactions.
In the field of nucleophilic substitution reactions, the bromine atom of 7-bromo-2 (H) -quinoline also exhibits high activity. Nucleophiles can attack positively charged carbon atoms with lone pair electrons, causing bromine atoms to leave and generate new substitution products. Nucleophiles such as alcohols and amines can react smoothly with 7-bromo-2 (H) -quinoline to generate quinoline derivatives containing different functional groups, which have wide application potential in pharmaceutical chemistry, materials science and other fields.
7-Bromo-2 (H) -quinoline also plays a key role in the cyclization reaction of complex quinoline compounds. By intramolecular or intermolecular cyclization with molecules containing specific functional groups, multi-ring quinoline derivatives can be formed. This process uses the synergistic reaction between bromine atoms and other functional groups to achieve the construction of carbon-carbon bonds or carbon-hetero bonds, thereby enriching the structural diversity of quinoline compounds, providing a powerful way to create compounds with unique biological activities or material properties. In conclusion, 7-bromo-2 (H) -quinoline is widely used in many organic chemical reactions such as halogenation, nucleophilic substitution, cyclization, etc. due to the unique activity of bromine atom, which is of great significance to the development of organic synthetic chemistry.

To prepare 2 - (2 - quinolinyl) -7 - bromide, there are three methods. First, 2 - quinolinone is used as the beginning, and it is brominated and replaced. First, dissolve 2 - quinolinone into an appropriate solvent, such as dichloromethane, add a brominating agent, such as bromine or N - bromosuccinimide, and react at a temperature control to obtain 7 - bromo - 2 - quinolinone. Then replace the hydroxyl group with a strong nucleophilic agent, such as sodium alcohol or amine, in a suitable temperature and solvent to form 2 - (2 - quinolinyl) -7 - bromide. < Br >
Second, based on 2-haloquinoline, react with bromine-containing reagents. Choose 2-chloroquinoline or 2-iodoquinoline, with bromine sources such as copper bromide and lithium bromide, in the presence of bases, such as potassium carbonate and sodium carbonate, in organic solvents such as N, N-dimethylformamide, heat reaction, halogen atoms are replaced by bromine to obtain the target product.
Third, it is prepared by cyclization reaction. With appropriate precursors containing bromine and quinoline structure fragments, under the action of catalysts, such as metal catalysts, palladium, nickel and other complexes, in bases and suitable solvents, intramolecular cyclization occurs to construct 2- (2-quinolinyl) -7-bromide structures. These three methods have their own advantages and disadvantages, and the actual application should be selected according to the requirements of raw material availability, cost, yield and purity.

2% 28H% 29 -quinoline-, 7 -bromo is 7-bromo-2 (1H) -quinolinone, which is used in medicine, materials and other fields.
In the field of medicine, it is a key intermediate in organic synthesis. Many drug research and development use it as a starting material, adding different functional groups through a series of chemical reactions to create compounds with specific biological activities. For example, in the development of anti-tumor drugs, 7-bromo-2 (1H) -quinolinone can be structurally modified to make the obtained new compounds fit the specific targets of tumor cells, and exert anti-tumor effects by interfering with tumor cell proliferation, invasion or inducing apoptosis. In terms of antibacterial drugs, the products after structural modification can change the ability to bind to key enzymes or proteins in bacteria, thereby hindering the normal physiological activities of bacteria and achieving antibacterial purposes.
In the field of materials, 7-bromo-2 (1H) -quinolinone can be used to prepare functional organic materials. Due to its unique molecular structure, it has certain photoelectric properties. For example, in the preparation of organic Light Emitting Diode (OLED) materials, introducing it into the material molecular structure can adjust the material energy level structure and luminescence properties, and improve the luminous efficiency, color purity and stability of OLED devices. In terms of chemical sensor materials, 7-bromo-2 (1H) -quinolinone can selectively interact with specific ions or molecules, and can be used for rapid detection of specific substances in environmental monitoring, biological analysis and other fields through rational design.