2-CYCLOPROPYL-4-(4-FLUOROPHENYL)QUINOLINE-3-CARBALDEHYDE, 96+%

2-Cyclopropyl-4- (4-fluorophenyl) quinoline-3-formaldehyde, 96 +% The most common application scenario of this substance is more common in the field of medicinal chemistry and organic synthesis.
In medicinal chemistry, it is often the key intermediate for the creation of new drugs. Due to the structure of quinoline, cyclopropyl, fluorophenyl, etc., the molecule is endowed with unique chemical and physical properties, which can precisely interact with specific targets in organisms. For example, in the development of some anti-cancer drugs, by modifying the structure of the compound, its targeting and inhibitory activity on cancer cells can be optimized, and the development of new anti-cancer drugs with better efficacy and fewer side effects can be assisted.
In the field of organic synthesis, it is an important starting material or intermediate, participating in the construction of complex organic molecular structures. Due to its special structure and multiple activity check points, it can introduce other functional groups through various chemical reactions, such as nucleophilic substitution, electrophilic addition, oxidation and reduction, etc., to expand the complexity and diversity of molecular structures, and lay the foundation for the synthesis of organic materials with special properties or biological activities.
Therefore, 2-cyclopropyl-4- (4-fluorophenyl) quinoline-3-formaldehyde, 96 +% plays a key role in medicine and organic synthesis, promoting continuous development and innovation in related fields.

To prepare 2-cyclopropyl-4- (4-fluorophenyl) quinoline-3-formaldehyde with a purity of 96 +%, the method is as follows:
First, 4-fluoroacetophenone and cyclopropyl formyl chloride are used as starting materials, and the acylation reaction is carried out in anhydrous aluminum trichloride catalysis and dichloromethane solvent. This reaction requires a low temperature environment, about 0 ° C to 5 ° C, and is stirred slowly to make the two fully react to produce intermediates. After the reaction is completed, quench with ice water, separate the organic phase, wash with water, dry, and distill under reduced pressure to obtain a pure intermediate product.
Then, the obtained intermediate product is blended with formamide and POCl, and at a suitable temperature, about 80 ° C to 90 ° C, the Vilsmeier-Haack reaction is performed. This reaction can make the intermediate product a key step in converting to the target product, and the reaction needs to be closely monitored. After the reaction is completed, pour it into ice water, adjust the pH to neutral with alkali solution, and then extract, dry, and column chromatography to obtain high purity 2-cyclopropyl-4- (4-fluorophenyl) quinoline-3-formaldehyde, with a purity of 96 +%. < Br > Another way is to use 4-fluorophenylboronic acid and 2-cyclopropyl-3-bromoquinoline as raw materials, in the presence of palladium catalyst, ligand and base, in an organic solvent, Suzuki coupling reaction is carried out. The reaction temperature is controlled at 60 ° C to 70 ° C, and the reaction proceeds smoothly. After the reaction is completed, after post-treatment, such as extraction, washing, drying, and then recrystallization or column chromatography, a high-purity target product can also be obtained, satisfying the purity of 96 +%.

2-Cyclopropyl-4- (4-fluorophenyl) quinoline-3-formaldehyde, content 96 +%, the physical and chemical properties of this substance are as follows:
Looking at its morphology, it is mostly solid at room temperature and pressure. The determination of its melting point is the key to the exploration of physical properties. After precise experiments, the melting point is within a specific range, and this value is of great significance for the purity identification of substances and subsequent applications.
When it comes to solubility, it shows different solubility characteristics in common organic solvents. In some polar organic solvents, such as ethanol and acetone, it can exhibit a certain solubility, while in non-polar organic solvents, such as n-hexane, the solubility is quite limited. This difference in solubility is due to the polar characteristics of its molecular structure, which has a significant impact on its dispersion and mixing behavior in different environments.
From the perspective of chemical stability, it has a certain stability under conventional conditions. In the case of strong oxidants or strong acids and bases, the chemical structure may be damaged, triggering corresponding chemical reactions. This is due to the activity of specific functional groups in the molecular structure, such as aldehyde groups, which are chemically active groups and are prone to participate in many chemical reactions such as oxidation and addition. < Br >
Its spectral characteristics cannot be ignored either. In infrared spectroscopy, each functional group produces absorption peaks in a specific wavenumber region, such as the C = O double bond stretching vibration absorption peak of the aldehyde group, which provides a strong basis for the identification of the substance. In nuclear magnetic resonance spectroscopy, hydrogen and carbon atoms in different chemical environments will show signal peaks at the corresponding chemical shifts, so that their molecular structures can be accurately analyzed.
The above physical and chemical properties are interrelated and affect each other, and play a key role in many fields such as the synthesis, separation, purification and practical application of substances.

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2-Cyclopropyl-4- (4-fluorophenyl) quinoline-3-formaldehyde, 96 +% The quality testing standard for this substance is related to its quality and is crucial in the fields of pharmaceuticals and chemicals.
Looking at its appearance, when it is in a specific color and shape, or in a crystalline state, and the color is pure and uniform, and there is no obvious variegation or foreign matter, it can be preliminarily proved to be pure.
Purity is a crucial item. Its standard is 96 +%. The detection requires high-end and precise instruments, such as high-performance liquid chromatography (HPLC), to accurately analyze its components to ensure that the impurity content is minimal and meets the standard. This can ensure the accuracy and stability of the reaction in subsequent applications.
Melting point is also an important indicator. The melting point range should be strictly measured by a melting point tester. Under a specific structure, there should be a corresponding melting point range. If it deviates, it indicates that its purity is questionable or the crystal form is abnormal.
Re-discuss the relevant substances. With the help of mass spectrometry (MS), nuclear magnetic resonance (NMR) and other technologies, the molecular structure is analyzed in detail, and potential impurities or by-products are screened to clarify their chemical properties and ensure that they meet quality standards.
Moisture content cannot be ignored. With precision techniques such as Karl Fischer's method, the moisture content is controlled within a suitable range, and the water resistance affects its chemical stability and reactivity. < Br >
With so many rigorous tests, high-quality 2-cyclopropyl-4- (4-fluorophenyl) quinoline-3-formaldehyde can be obtained to meet the stringent needs of various fields.