2-Chloro-6-Bromoquinoline

2-Chloro-6-bromoquinoline is one of the organic compounds. Its main uses are quite extensive and common in the field of organic synthesis.
In pharmaceutical chemistry, this compound is often a key intermediate. Due to its unique structure, it can be derived from various bioactive molecules through various chemical reactions. Drug developers are expected to create new drugs by modifying and modifying its structure to deal with various diseases. For example, it may be used to synthesize drug molecules with antibacterial, anti-inflammatory, anti-tumor and other effects, which can benefit human health.
In the field of materials science, 2-chloro-6-bromoquinoline also shows potential value. It can be used as a basic raw material for the construction of functional materials. After specific reactions and assemblies, materials with unique optical and electrical properties can be prepared, which can be used in fields such as photoelectric displays and sensors to promote the progress of materials science.
In addition, in chemical research, because it contains halogen atoms such as chlorine and bromine, it can be used to explore many chemical reaction mechanisms such as nucleophilic substitution and metal catalytic coupling. Chemists use it as a substrate to carry out reactions, gain in-depth insight into the reaction process, optimize reaction conditions, and provide assistance for the development of organic synthesis methodologies.

There are several common methods for the synthesis of quinoline 2-chloro-6-bromoquinoline.
First, quinoline is used as the starting material. First, the quinoline is brominated. Liquid bromine and an appropriate catalyst, such as iron powder or iron tribromide, can be selected. In a suitable solvent, such as dichloromethane, liquid bromine is slowly added dropwise at low temperature, and bromine atoms will selectively enter the 6-position of the quinoline ring to generate 6-bromoquinoline. Subsequently, 6-bromoquinoline is chlorinated by chlorine gas or chlorination reagents such as N-chlorosuccinimide (NCS), in the presence of light or free radical initiator, to achieve 2-position chlorination to obtain 2-chloro-6-bromoquinoline.
Second, starting from aniline derivatives. First, the quinoline ring is constructed by Skraup reaction. The aniline derivative is co-heated with glycerol, concentrated sulfuric acid and appropriate oxidants such as nitrobenzene to form quinoline compounds. Then, the steps of bromination and chlorination are carried out in sequence. The bromination and chlorination conditions are similar to those of the above-mentioned quinoline as raw materials. By reasonably controlling the reaction conditions and the amount of reagents, the purpose of introducing chlorine atoms at the 2-position and bromine atoms at the 6-position of the quinoline ring is achieved.
Third, the coupling reaction catalyzed by transition metals is carried out with halogenated aromatics as raw materials. For example, the Ullmann reaction of 2-chloro-6-iodobenzene with cuprous bromide and nitrogenous ligand under alkaline conditions can construct a quinoline ring and introduce bromine atoms at the same time. This process requires strict control of the reaction temperature, time and the proportion of reagents to increase the yield of 2-chloro-6-bromoquinoline.

2-Chloro-6-bromoquinoline is one of the organic compounds. Its physical properties are quite important and are related to many chemical applications.
Looking at its properties, 2-chloro-6-bromoquinoline is often in a solid state at room temperature and pressure. The appearance of this solid may be crystalline, dense and regular, and its color is often white to light yellow, just like the early morning sun shining on the crystal, slightly yellow.
When it comes to melting point, the melting point of this compound is about a specific range, usually within a certain temperature range, depending on factors such as intermolecular forces and crystal structure. The exact value of the melting point is crucial for the identification and purification of this compound, like a navigational landmark, guiding chemists to find pure products in the ocean of complex chemicals.
As for the boiling point, under appropriate pressure conditions, when 2-chloro-6-bromoquinoline reaches the boiling point, it converts from liquid to gaseous state. The level of boiling point reflects the strength of intermolecular interactions and is closely related to the volatility of the compound.
In terms of solubility, 2-chloro-6-bromoquinoline has different solubility in common organic solvents. In some organic solvents, such as ethanol, dichloromethane, etc., there may be a certain solubility, because some groups in the molecular structure can form interactions with organic solvent molecules, such as van der Waals force, hydrogen bond, etc. However, in water, its solubility is relatively low, because the hydrophobic part of its molecules accounts for a large proportion, and the molecular force between water and compounds is difficult to overcome its own molecular force, so it is difficult to dissolve.
Density is also one of its physical properties. Its density indicates the mass of a substance per unit volume. This property is of great significance in many chemical operations, such as the preparation of reaction systems and the separation process. It is like a weight on the balance to accurately measure the relationship between the quantity and volume of a substance.
In summary, the physical properties of 2-chloro-6-bromoquinoline, such as its appearance, melting point, boiling point, solubility, and density, provide an important basis for chemists to study its chemical behavior and conduct related experimental operations, and occupy an indispensable position in the field of organic chemistry.

2-Chloro-6-bromoquinoline is one of the organic compounds. In its molecular structure, the second position of the quinoline ring is replaced by the chlorine atom, and the sixth position is replaced by the bromine atom. This compound has unique chemical properties.
In terms of its chemical activity, the presence of halogen atoms gives it active reaction characteristics. Both chlorine and bromine atoms are electron-withdrawing groups, which can reduce the electron cloud density of the quinoline ring and change the activity of the electrophilic substitution reaction on the ring. In the electrophilic substitution reaction, the localization effect of the halogen atom is significant, because it is an adjacent and para-localization group, but because of its electron-withdrawing properties, the reaction mainly occurs in the meso-site.
In nucleophilic substitution reactions, the chlorine and bromine atoms in 2-chloro-6-bromoquinoline can be used as leaving groups to react with nucleophilic reagents. Usually, bromine atoms are more likely to leave than chlorine atoms. Because the bond energy of carbon-bromine bonds is slightly lower than that of carbon-chlorine bonds, bromine atoms preferentially participate in nucleophilic substitution reactions under appropriate conditions.
In addition, 2-chloro-6-bromoquinoline can also participate in metal-catalyzed reactions, such as palladium-catalyzed coupling reactions. In such reactions, halogen atoms can form intermediates with metal catalysts, and then couple with other organic reagents to realize the construction of carbon-carbon bonds or carbon-heteroatomic bonds, which are widely used in the field of organic synthesis.
In terms of physical properties, 2-chloro-6-bromoquinoline is generally solid, with a certain melting point and boiling point. Due to the presence of aromatic rings and polar halogen atoms in its molecules, its solubility varies from different solvents. In polar organic solvents such as ethanol and acetone, its solubility may be better than that of non-polar solvents such as n-hexane.
Furthermore, the stability of this compound is also worthy of attention. Although the quinoline ring structure is relatively stable, the presence of halogen atoms makes the local charge distribution of the molecule uneven, and under extreme conditions such as high temperature, strong acid, and strong base, decomposition or other chemical reactions may occur.
In short, 2-chloro-6-bromoquinoline exhibits rich and diverse chemical properties due to its unique molecular structure, which is of important research and application value in organic synthesis and related fields.

The price of 2-chloro-6-bromoquinoline in the market is difficult to determine. This is due to various factors, resulting in unstable price fluctuations.
First, the price of raw materials has a significant impact on the cost of 2-chloro-6-bromoquinoline. If the price of chlorine, bromine and quinoline raw materials required for the synthesis of this substance increases, the price of the finished product will also rise; conversely, if the price of raw materials decreases, the price may decrease.
Second, the supply and demand situation is also critical. If the market demand for 2-chloro-6-bromoquinoline is strong, but the supply is limited, the price will rise; if the supply exceeds the demand, the merchant will sell its goods or reduce the price.
Furthermore, the preparation method and the process are complicated and simple, but also related to cost and price. The efficient and convenient method can reduce the cost and make the price close to the people; if the process is complicated and time-consuming, the price will be high.
In addition, the intensity of market competition also has an impact. Competing in the same industry, or adjusting the price for a share. Many competing to sell 2-chloro-6-bromoquinoline, the price may drop due to competition; if there are few suppliers in the market, the price may be high.
And different suppliers, due to their own cost structure and business strategies, set different prices. Large suppliers have good scale and benefits, and the price may be better; small suppliers have high cost and the price may be slightly more expensive.
Therefore, the price of 2-chloro-6-bromoquinoline may be between a few yuan per gram and tens of yuan, or even higher, which is difficult to determine. To know the details, you need to carefully observe the market dynamics and consult the suppliers to get a near real-time price.