What is the main use of 2-chloro-6, 7-dimethoxyquinazolin-4-amine?

2-Chloro-6,7-dimethoxyquinazoline-4-amine is one of the organic compounds. Its main uses are quite extensive, and it is often used as a key intermediate in the field of medicinal chemistry. This compound plays a crucial role in the development of new drugs.

Geinquinazoline compounds often exhibit a variety of biological activities, such as anti-tumor, antibacterial, anti-inflammatory and antiviral effects. 2-Chloro-6,7-dimethoxyquinazoline-4-amine Due to its unique molecular structure, or through specific chemical reactions, a series of derivatives with potential pharmacological activities can be derived.

For example, in the research and development process of anti-tumor drugs, researchers can modify and modify their structures to enable them to precisely target specific targets of tumor cells, thereby inhibiting the growth and proliferation of tumor cells, providing a new opportunity and direction for combating tumor diseases.

In the field of pesticide chemistry, such compounds may also have potential application value. Or they can be properly optimized to have biological activities such as insecticidal and bactericidal, becoming an important starting material for the creation of new pesticides, helping agricultural production resist the infestation of diseases and pests, and ensuring the yield and quality of crops.

In summary, 2-chloro-6,7-dimethoxyquinazoline-4-amine has attracted the attention and attention of researchers because of its great potential in the fields of medicine and pesticide research and development. It is an important research object in many fields such as organic synthesis and medicinal chemistry.

What are the synthesis methods of 2-chloro-6, 7-dimethoxyquinazolin-4-amine

The preparation of 2-chloro-6,7-dimethoxyquinazoline-4-amine can be obtained by multiple methods. One of the common ones is to use 2-amino-3,4-dimethoxybenzoic acid as the starting material, first co-heat with phosphorus oxychloride, and then change through amidation and cyclization to obtain 6,7-dimethoxyquinazoline-4-alcohol, and then use a chlorination agent, such as dichlorosulfoxide, to interact with it, change the hydroxyl group to chlorine, and obtain 2-chloro-6,7-dimethoxyquinazoline-4-one, and then use a reducing agent, such as sodium borohydride-zinc chloride system, to convert the carbonyl group to an amino group, and then obtain the target product.

Second, based on 2-chloro-6,7-dimethoxy quinazoline, it is first reacted with ammonia water or amination reagent at suitable temperature and pressure. After nucleophilic substitution, the nitrogen atom attacks the 4-position carbon of the quinazoline ring, breaks the carbon-chlorine bond, and forms 2-chloro-6,7-dimethoxy quinazoline-4-amine.

There is also a method of multi-step condensation and cyclization with aniline compounds containing corresponding substituents, formylating reagents and cyanidating agents. Initially, aniline is formylated, then condensed with cyanide, and then cyclized, chlorinated, aminated, etc., which can also achieve the goal. Each method has its own advantages and disadvantages, and it is necessary to choose the appropriate method according to the requirements of easy availability of raw materials, cost, yield and purity.

What are the physical and chemical properties of 2-chloro-6, 7-dimethoxyquinazolin-4-amine

2-Chloro-6,7-dimethoxyquinazoline-4-amine is an organic compound with unique physical and chemical properties.

Looking at its properties, it is either solid at room temperature, or due to intermolecular forces and structural arrangement, it is powdery, fine and uniform, and the color is either white or slightly yellow, just like a thin frost in winter or a light color in the morning.

When it comes to solubility, its performance in organic solvents varies. In polar organic solvents such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), or due to the formation of hydrogen bonds between molecules and solvents, dipole-dipole interactions, etc., exhibit good solubility, soluble and mixed into a uniform liquid phase, just like fish entering water, the phase is fused infinitely; in water, due to the difference between molecular polarity and water, coupled with the influence of hydrophobic groups, the solubility is poor, or if sand sinks to the bottom, it can only be dispersed in a small amount, and it is difficult to form a homogeneous phase.

In terms of melting point and boiling point, the melting point is restricted by intramolecular hydrogen bonds, van der Waals forces, etc., and is in a specific temperature range. When the temperature rises to the melting point, the molecule is able to break free from the lattice, from the solid state to the liquid state, just like ice disappearing under the warm sun; the boiling point is determined by the intermolecular force and the relative molecular mass, and higher energy is required to make the molecule escape the liquid phase and enter the gas phase, just like hydration into steam, rising into the air.

This compound contains functional groups such as chlorine atoms, methoxy groups, and amino groups, and is chemically active. The chlorine atom has nucleophilic substitution activity. If it encounters a nucleophilic reagent, it is like a warrior meeting an enemy and is prone to substitution reaction. The chlorine atom can be replaced by other groups. The methoxy group has a donor electron effect and can affect the electron cloud density of the benzene ring, which increases the electron cloud density of the benzene ring o-para-position, making the compound more likely to react in the o-para-position during the electrophilic substitution reaction, just like indicating the direction of the reaction. Amino groups are both basic and can form salts with acids, and can also participate in many reactions. For example, they react with acyl chloride to form amides, which seem to form new relationships with other substances and are widely used in the field of organic synthesis.

What is the market prospect of 2-chloro-6, 7-dimethoxyquinazolin-4-amine?

Today, there are 2-chloro-6,7-dimethoxyquinazoline-4-amine, and its market prospects are related to many aspects. This compound may have considerable potential in the field of pharmaceutical research and development. The structure of Gainquinazoline is often valued by pharmaceutical chemists, and many marketed drugs contain this core structure. 2-chloro-6,7-dimethoxyquinazoline-4-amine may use its unique structure to show affinity at specific targets, and then be developed into new therapeutic drugs, such as anti-tumor, anti-virus and the like.

There is also room for exploration in the creation of pesticides. Some compounds containing quinazoline structure have significant biological activity against pests, or can be used as precursor compounds for insecticides and fungicides. After reasonable modification and optimization, new pesticides with high efficiency, low toxicity and environmental friendliness may be developed.

However, its market prospects also pose challenges. The development of new drugs or new pesticides takes a long time and costs a lot, and requires multiple rounds of strict experiments and approvals. And the market competition is fierce. To stand out, it is necessary to highlight unique advantages. If we can effectively solve the research and development problems and give full play to the structural characteristics, 2-chloro-6,7-dimethoxy quinazoline-4-amine will occupy a place in the market, and the future may be bright.

What are the advantages of 2-chloro-6, 7-dimethoxyquinazolin-4-amine in related fields?

2-Chloro-6,7-dimethoxyquinazoline-4-amine has many advantages in related fields such as medicine and pesticides.

In the field of medicine, it has a unique molecular structure and is endowed with excellent biological activity. It can be used as a kinase inhibitor, showing high affinity and inhibition of specific kinases. In the cell signal transduction pathway, kinases perform key signal transmission. If their function is abnormal, they often cause abnormal cell proliferation and differentiation, leading to tumors and other diseases. By precisely inhibiting related kinases, this compound may effectively regulate cell proliferation and apoptosis, opening a new path for the development of tumor-targeted therapeutic drugs. And its chemical structure is stable, during the metabolism process in the body, it can maintain activity, improve drug efficacy and bioavailability, reduce the frequency and dose of administration, reduce the adverse reaction of the drug to the body, and improve the compliance of patients with medication.

In the field of pesticides, the compound may have significant insecticidal and bactericidal activities. With its special structure, it can interfere with the nervous system of pests or the physiological metabolic process of pathogens. Such as acting on pest neurotransmitter receptors, blocking nerve signal transduction, paralyzing and killing pests; or inhibiting the activity of key enzymes in the cell wall synthesis and respiratory metabolism of pathogens, hindering the growth and reproduction of pathogens, and assisting the creation of new high-efficiency and low-toxicity pesticides, providing a powerful choice for green prevention and control of agricultural pests.