2-chloro-3-hydroxy-quinoline-4-carboxylic acid

2-Chloro-3-hydroxy-quinoline-4-carboxylic acid, this substance has a wide range of uses. In the field of medicine, it is often used as a key intermediate to help synthesize a variety of drugs. Due to its unique molecular structure and certain biological activity, it can provide a core framework for the development of antibacterial and anti-inflammatory drugs. With the help of specific chemical reactions, its structure can be modified to obtain drug molecules with stronger activity and targeting.
In the field of materials science, it also has a place. Because it contains special functional groups, it can participate in material preparation and improve material properties. For example, when used to prepare fluorescent materials, it can endow the material with unique optical properties, which makes the material exhibit excellent performance in optoelectronic devices, such as Light Emitting Diodes, sensors and other fields.
In the field of chemical research, as an important organic synthesis intermediate, it provides a foundation for the construction of complex quinoline compounds. Chemists can use its structural characteristics to synthesize a variety of compounds with potential application value through different reaction paths, expand the boundaries of organic synthesis chemistry, and promote the development of related disciplines.

2-Chloro-3-hydroxy-quinoline-4-carboxylic acid, this property belongs to the category of chemistry, which is related to its physical properties. Let me explain in detail.
Looking at its morphology, under normal temperature, it is mostly in a solid state. Its color is often white to light yellow powder, with a fine texture and can be seen. This color state also has its own unique appearance among many chemical substances.
As for the melting point, after experimental investigation, it is about a specific temperature range. The melting point, the critical temperature at which a substance changes from solid to liquid, is crucial for the identification and purification of this compound. The melting point of this compound is actually a major indicator of its physical properties. < Br >
In terms of solubility, it exhibits specific solubility characteristics in common organic solvents. In some polar solvents, such as ethanol and dimethyl sulfoxide, it can be moderately dissolved, which is caused by the interaction between molecular structure and solvent. In non-polar solvents, such as n-hexane, the solubility is poor. This solubility characteristic is an important consideration in chemical synthesis, separation and purification.
In addition, its density is also one of the physical properties. Although the specific value needs to be accurately measured, the characterization of the density has a great impact on the scenes of chemical production and material mixing.
Furthermore, the stability of this substance is also within the scope of physical properties. Under normal temperature and pressure and no special chemical reaction conditions, it is relatively stable. In case of high temperature, strong light or specific chemical reagents, or cause structural changes, the stability is disturbed.
In summary, the physical properties of 2-chloro-3-hydroxy-quinoline-4-carboxylic acids, such as morphology, color, melting point, solubility, density and stability, are of great significance in chemical research, chemical production and related fields, laying the foundation for in-depth exploration of their chemical behavior and applications.

To prepare 2-chloro-3-hydroxy-quinoline-4-carboxylic acid, the method is as follows:
First take a suitable quinoline compound as the starting material, and the structure of this raw material needs to contain groups that can be modified for subsequent reactions. Usually start with 4-carboxylic acid-quinoline derivatives, because they already have a partial structural framework of the target product, which can reduce the synthesis steps and difficulty.
In an appropriate reaction vessel, mix the starting material with an appropriate amount of chlorination reagent, such as chlorine reagent such as phosphorus oxychloride, which can provide chlorine atoms to achieve 2-position chlorination reaction. The reaction system needs to be carried out at a certain temperature and reaction time, and the temperature is mostly controlled in a moderate range, depending on the specific reaction conditions, or it needs to be heated to make the reaction fully proceed. At the same time, attention should be paid to the reaction environment, such as ensuring that the reaction system is dry and free of impurity interference, so as to facilitate the chlorination reaction to occur smoothly and generate 2-chloro-quinoline-4-carboxylic acid intermediates.
Then, transfer this intermediate to another reaction environment, add suitable hydroxylation reagents, such as alkali metal hydroxide solution. Under appropriate reaction conditions, alkali metal ions can promote the substitution of hydroxyl groups at specific positions, thereby introducing hydroxyl groups at the 3-position. This step also requires strict control of the reaction temperature, time and reagent dosage to avoid overreaction or side reactions.
After the reaction is completed, a series of separation and purification operations, such as extraction, recrystallization, etc., are used to obtain the pure 2-chloro-3-hydroxy-quinoline-4-carboxylic acid product. During extraction, a suitable organic solvent is selected to separate the product by using the difference in solubility between the product and the impurities in different solvents; recrystallization can further purify the product, remove residual impurities, improve the purity of the product, and finally obtain the desired 2-chloro-3-hydroxy-quinoline-4-carboxylic acid.

It is difficult to determine the price of 2-chloro-3-hydroxy-quinoline-4-carboxylic acid in the market. This is due to the complex market conditions, and the price changes are changeable and subject to various factors.
Looking at the past, the price of chemical raw materials often fluctuated due to changes in supply and demand, differences in raw material costs, progress in production technology and policy regulations. If the demand for this product is strong, and the supply is limited, the price may rise; on the contrary, if the supply exceeds demand, the price will decline.
The cost of raw materials is also a major factor. If the price of the raw materials required for the preparation of this product increases, the production cost will increase, and the market price may be high; if the price of raw materials falls, the product price may be lowered.
Furthermore, the innovation of production technology can lead to changes in production efficiency. If the new technology can increase the yield and reduce the cost, the price may decrease accordingly; if the production technology is stagnant, it is difficult to respond to the new market demand, and the price may also be suppressed.
Policies and regulations regulate the production, sales and transportation of chemicals. If the policy is tightened, production is restricted and costs rise, and the price will be affected.
As for the exact price, you may need to consult chemical raw material suppliers, traders, or professional chemical product trading platforms to obtain a more accurate price at the moment. Because the specific market conditions are not known, it is difficult to know the exact price range. However, based on the above factors, it is possible to know the change of the price.

2-Chloro-3-hydroxy-quinoline-4-carboxylic acid is a special chemical substance. It is very important to pay attention to its safety precautions.
First, this substance is chemically active. When operating, be sure to wear appropriate protective equipment. Such as thick protective gloves, which can prevent it from coming into contact with the skin and prevent the skin from being irritated or absorbed, resulting in adverse consequences; wearing goggles can protect the eyes from possible splashes or volatile substances. Because the skin around the eyes is delicate, if it is attacked by chemicals, the consequences will be unimaginable.
Second, the operating environment must be well ventilated. Because it may volatilize harmful gases, it accumulates in a closed space, inhales the human body, and damages the respiratory system. Good ventilation can quickly dissipate volatile gases, ensuring the safety of the operator's breathing.
Third, strictly control the storage conditions. It should be stored in a cool, dry place, away from fire and oxidants. Excessive temperature or humid environment, or cause its properties to change, causing danger. Contact with oxidants, or trigger violent chemical reactions, such as combustion, explosion, etc.
Fourth, in the process of taking and weighing, the action must be precise and careful. Due to its special chemical properties, improper dosage may affect the experimental results or cause accidents. After taking it, seal the container in time to prevent it from reacting with air components and to avoid its release into the environment.
Fifth, in the event of a leak, do not panic. It should be dealt with immediately in accordance with established emergency procedures. Small leaks can be collected with suitable adsorption materials and properly disposed of; large leaks, quickly evacuate personnel, block the scene, and report to professionals to prevent the expansion of hazards.
In short, when dealing with 2-chloro-3-hydroxy-quinoline-4-carboxylic acid, it is necessary to adhere to a rigorous scientific attitude and strictly abide by safety regulations to ensure safe operation and avoid accidents.