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2-Butoxy-N- [2- (diethylamino) ethyl] quinoline-4-carboxamide what is the chemical structure of dihydrochloride
This is the chemical structure of 2-butoxy-N - [2 - (diethylamino) ethyl] quinoline-4-formamide dihydrochloride. Its chemical structure can be resolved as follows:
This compound is based on a quinoline ring, with a formamide group at the 4th position of the quinoline ring. The nitrogen atom in the formamide is connected to an ethyl group containing diethylamino, and the quinoline ring is connected to a butoxy group at the 2nd position. The state of dihydrochloride is due to the presence of basic groups in the molecule, which can react with hydrochloric acid to form salts.
From the perspective of chemical structure, the quinoline ring is an aromatic heterocyclic ring with a conjugated system, which imparts specific stability and electronic properties to the compound. Formamide is a group with a certain polarity, which may affect the solubility and reactivity of the compound. The introduction of diethylaminoethyl adds the basicity and nucleophilicity of the molecule, or can participate in a variety of chemical reactions. Butyloxy is a long-chain alkyl group, which can affect the lipid solubility and steric resistance of the compound.
The overall chemical structure of this compound determines its physical and chemical properties and possible biological activities, and may be of great significance in the fields of medicinal chemistry and organic synthesis. The characteristics of its structure and the interaction between various groups may provide opportunities and directions for the development of new drugs or the development of organic synthesis reactions.
What are the main uses of 2-butoxy-N- [2- (diethylamino) ethyl] quinoline-4-carboxamide dihydrochloride
2-butoxy-N - [2 - (diethylamino) ethyl] quinoline-4-formamide dihydrochloride, this is an organic compound with a wide range of uses.
In the field of pharmaceutical research and development, it is often used as a lead compound for active pharmaceutical ingredients. Physicians and researchers explore its pharmacological properties and biological activities, hoping to develop new therapeutic drugs. Or because of its specific groups such as quinoline and amide in its structure, it has unique chemical activities and biological affinity, and can interact with specific targets in organisms, such as binding to certain receptors and enzymes, regulating physiological processes in organisms to treat related diseases.
In the field of materials science, it also has potential uses. Due to its special chemical structure, it can be used to prepare functional materials. If chemically modified, the compound has specific photoelectric properties, which can be used to make organic Light Emitting Diodes, sensors and other materials. By interacting with specific substances, it can detect and respond to specific molecules or physical quantities in the environment.
In the field of organic synthesis, it can be used as a key intermediate. Chemists use its structural characteristics to introduce other functional groups through various chemical reactions to synthesize more complex organic compounds with specific functions. Due to the fact that different functional groups in its structure can participate in the reaction, it provides multiple pathways and possibilities for organic synthesis, assisting in the construction of diverse organic molecular structures, and expanding the variety and application scope of organic compounds.
What are the physical properties of 2-butoxy-N- [2- (diethylamino) ethyl] quinoline-4-carboxamide dihydrochloride
2-Butoxy-N- [2- (diethylamino) ethyl] quinoline-4-formamide dihydrochloride, which is an organic compound. Looking at its physical properties, it is mostly solid at room temperature. Its melting point is quite critical, but the specific value needs to be determined according to precise experiments, which may vary slightly due to different experimental conditions.
When it comes to solubility, it shows certain solubility characteristics in organic solvents. Common organic solvents such as ethanol and dichloromethane have a certain solubility to it. The structure of the compound contains not only hydrophobic butoxy and quinoline ring parts, but also hydrophilic amino and amide groups. This special structure makes it soluble in organic solvents. In water, due to the large proportion of hydrophobic components in the overall structure, the solubility is relatively limited.
Furthermore, its appearance may be white to off-white powder, and this appearance characteristic is also often possessed by this type of organic compound. The morphology of the powder may be related to the synthesis and crystallization processes, and different preparation processes may affect the appearance details such as its particle size and aggregation state.
Its density and other physical properties are also closely related to the molecular structure and intermolecular forces. Due to the complex molecular structure and diverse intermolecular forces, the specific density value also needs to be accurately measured with the help of professional instruments. And the physical properties of the compound, its synthesis, separation, purification and application, are of important guiding significance, and are key factors for researchers to explore its performance and use.
What is the synthesis method of 2-butoxy-N- [2- (diethylamino) ethyl] quinoline-4-carboxamide dihydrochloride
2-Butoxy-N - [2 - (diethylamino) ethyl] quinoline-4-formamide dihydrochloride, this is an organic compound, and its synthesis method is as follows:
The starting material is 4-chloroquinoline-2-carboxylic acid. After esterification, with butanol under acid catalysis, such as concentrated sulfuric acid, in the state of heating reflux, 4-chloroquinoline-2-butyl carboxylate is obtained. This step can convert the carboxyl group into an ester group, which is the basis for subsequent reactions.
Then, 4-chloroquinoline-2-butyl carboxylate reacts with N- (2-diethylaminoethyl) amine. In a suitable organic solvent, such as toluene, a base such as potassium carbonate is added as an acid binding agent, heated and stirred, and a nucleophilic substitution reaction occurs. The chlorine atom is replaced by N- (2-diethylaminoethyl) amine to form 2-butoxy-N- [2 - (diethylamino) ethyl] quinoline-4-formamide.
Finally, 2-butoxy-N - [2 - (diethylamino) ethyl] quinoline-4 - formamide is placed in anhydrous ether and other solvents, and dry hydrogen chloride gas is introduced to obtain the target product 2-butoxy-N - [2 - (diethylamino) ethyl] quinoline-4 - formamide dihydrochloride. The whole synthesis process needs to pay attention to the control of reaction conditions, such as temperature, pH, etc., to ensure the smooth progress of each step of the reaction and the purity of the product.
What are the precautions for the use of 2-butoxy-N- [2- (diethylamino) ethyl] quinoline-4-carboxamide dihydrochloride
2-butoxy-N - [2 - (diethylamino) ethyl] quinoline-4-formamide dihydrochloride, this is a special chemical agent, when using, many things need to be paid attention to.
First safety protection. Because of its chemical activity, or harmful to the human body. When in contact, be sure to wear appropriate protective equipment, such as laboratory clothes, gloves and goggles. This can effectively avoid direct contact with the skin and eyes, to prevent irritation, allergies and even more serious damage.
The operating environment is also very critical. Operate in a well-ventilated place, preferably with a fume hood. This can disperse harmful gases or generated during operation in time, reduce the concentration of the agent in the air, and ensure the safety of the operator's breathing.
Furthermore, accurate access and weighing are indispensable. The accuracy of the dosage of this agent has a great impact on the experimental results or application effectiveness. When taking it, it is necessary to use a precise measuring tool and strictly follow the operating procedures to avoid experimental failure or adverse consequences due to dosage deviation.
Storage should not be ignored. It should be stored in a suitable environment according to its characteristics. Generally speaking, it should be placed in a dry, cool and dark place to prevent moisture, heat and light, so as not to affect the stability and quality of the agent.
In addition, the use process should be recorded in detail. Include access time, dosage, operation steps and related phenomena. Detailed records not only help to analyze and reproduce experimental results, but also provide an important basis for finding the cause in case of problems.
Use 2-butoxy-N- [2- (diethylamino) ethyl] quinoline-4-formamide dihydrochloride, and be sure to treat the above precautions with caution to ensure operation safety and effectiveness.