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What is the chemical structure of 2- [ (4-Ethenylphenyl) methyl] -1H-benz [de] isoquinoline-1,3 (2H) -dione
This is an investigation into the chemical structure of 2- [ (4-vinylphenyl) methyl] -1H-benzo [de] isoquinoline-1,3 (2H) -dione. Looking at its name, it can be analyzed step by step.
"2- [ (4-vinylphenyl) methyl]", indicated at a specific position (No. 2) of the main structure, with 4-vinylphenyl as a substituent, and connected by methylene (-CH 2O -). Vinylphenyl, that is, the 4th position of the styrene ring is connected with vinyl (-CH = CH 2O).
"1H-benzo [de] isoquinoline-1,3 (2H) -dione", the core structure is benzoisoquinoline dione. Benzoisoquinoline is formed by fusing the benzene ring with the isoquinoline ring. 1H indicates that there is a hydrogen atom at position 1, and 1,3 (2H) -dione refers to the presence of a carbonyl group (C = O) at position 1 and position 3 (2H means that hydrogen atom at position 2 participates in the relevant bonding).
In summary, the structure of this compound is dominated by benzoisoquinoline dione, and the methylene at position 2 is connected to 4-vinylphenyl. Its unique structure, with the characteristics of styrene ring, isoquinoline ring and vinyl, may have potential uses in organic synthesis, medicinal chemistry and other fields.
What are the main uses of 2- [ (4-Ethenylphenyl) methyl] -1H-benz [de] isoquinoline-1,3 (2H) -dione
2-%5B%284-Ethenylphenyl%29methyl%5D-1H-benz%5Bde%5Disoquinoline-1%2C3%282H%29-dione, this is an organic compound. It has a wide range of applications and is of great value in many fields.
In the field of medicine, it may have potential biological activity and can be used as a lead compound for drug research and development. Due to the special structure of the compound, it may interact with specific targets in the body, and then show the efficacy of treating diseases. For example, after research, it may be found that it has inhibitory effects on the growth and spread of certain cancer cells, or has a modulating effect on specific inflammatory reactions, laying the foundation for the development of new anti-cancer drugs or anti-inflammatory drugs.
In the field of materials science, it can be used to prepare functional polymer materials. Its structure gives the material unique properties, such as good optical properties. The preparation of optical materials can be used in optical instruments, display technology and other fields to improve the optical resolution and stability of the material, so that the display effect is clearer and more stable.
Furthermore, in the field of organic synthesis, this compound can act as a key intermediate. With its specific functional groups, it can derive compounds with more complex and diverse structures through various organic reactions, expand the types and properties of organic compounds, provide rich raw materials and paths for the development of organic synthetic chemistry, and promote the continuous progress of organic synthesis technology to meet the needs of different fields for special organic compounds.
What is the synthesis method of 2- [ (4-Ethenylphenyl) methyl] -1H-benz [de] isoquinoline-1,3 (2H) -dione
To prepare 2- [ (4-vinylphenyl) methyl] -1H-benzo [de] isoquinoline-1,3 (2H) -dione, the method is as follows:
First take an appropriate amount of raw materials, such as the precursor of benzoisoquinoline dione with a specific substituent, which is the basis for the reaction. 4-vinylbenzyl halide is also prepared, and its halogen atom is active, which is conducive to nucleophilic substitution. < Br >
In a suitable reaction vessel, an inert organic solvent, such as dichloromethane, N, N-dimethylformamide, etc., is placed to provide a uniform reaction environment for the reactants without interfering with the reactants.
The above-mentioned benzisoquinoline dione precursor and 4-vinyl benzyl halide are put into the solvent in a suitable molar ratio. Usually, the ratio of the two needs to be optimized by experiments to achieve the best yield. Add an appropriate amount of alkali, such as potassium carbonate, sodium carbonate, etc. The function of the base is to neutralize the hydrogen halide generated by the reaction and promote the forward reaction. < Br >
During the reaction, the temperature should be controlled within an appropriate range, depending on the activity and reaction mechanism of the reactants, either low temperature is required to prevent side reactions, or temperature can be increased to increase the rate, generally between room temperature and 80 ° C. And during the reaction, magnetic stirring or mechanical stirring is used to make the reactants fully contact and the reaction is uniform.
After a certain period of reaction, the reaction process is monitored by thin-layer chromatography or other suitable analytical means. When the raw material point is basically eliminated, it shows that the reaction is nearly complete.
Then, pour the reaction mixture into an appropriate amount of water, extract the product with an organic solvent, and extract it several times to enrich the product in the organic phase. Then the water in the organic phase is removed with a desiccant such as anhydrous sodium sulfate, and the desiccant is filtered off.
Finally, the organic solvent is removed by reduced pressure distillation to obtain a crude product. The crude product is refined by column chromatography or recrystallization to obtain a pure 2 - [ (4-vinylphenyl) methyl] -1H -benzo [de] isoquinoline-1,3 (2H) -dione product. In this way, it can be synthesized.
What are the physical properties of 2- [ (4-Ethenylphenyl) methyl] -1H-benz [de] isoquinoline-1,3 (2H) -dione
2-%5B%284-Ethenylphenyl%29methyl%5D-1H-benz%5Bde%5Disoquinoline-1%2C3%282H%29-dione is an organic compound with specific physical properties.
Looking at its appearance, under normal temperature and pressure, it is mostly in a solid state. Due to the relatively strong intermolecular forces, the molecules are arranged in an orderly manner, resulting in a solid state. Its color may vary depending on the purity and preparation method. High purity or white crystalline powder, if it contains impurities, it may have a little color.
Melting point is one of its important physical properties. It has been experimentally determined that its melting point is in a specific temperature range, which is crucial for the identification and purification of the compound. Due to the different melting points of different compounds, its purity can be judged. When heated to this temperature range, the compound gradually melts from a solid state to a liquid state.
In terms of solubility, this compound has good solubility in organic solvents. For example, in common organic solvents such as dichloromethane and chloroform, it can show good solubility. This is due to the interaction between its molecular structure and organic solvent molecules, such as van der Waals force, hydrogen bond, etc., which prompts the two to dissolve each other. However, in water, its solubility is poor. Due to the weak interaction between water molecules and the compound molecules, it is difficult to overcome the intermolecular force of the compound, so it is difficult to dissolve.
In addition, the compound may have certain stability. Under normal environmental conditions, it is properly stored in a closed container, and its chemical properties are relatively stable, and it is not easy to spontaneously react. However, under certain conditions, such as high temperature, strong oxidizing agent or reducing agent, chemical reactions may be triggered, resulting in changes in structure and properties.
The physical properties of this compound are of great significance in the fields of organic synthesis and materials science. According to its solubility and stability, researchers can design a reasonable synthesis route, select a suitable reaction solvent, ensure the smooth progress of the reaction, and lay the foundation for the development of new materials.
What is the safety of 2- [ (4-Ethenylphenyl) methyl] -1H-benz [de] isoquinoline-1,3 (2H) -dione
2-%5B%284-Ethenylphenyl%29methyl%5D-1H-benz%5Bde%5Disoquinoline-1%2C3%282H%29-dione is an organic compound, and its safety is related to many aspects. Let me tell you one by one.
In terms of toxicity, the toxicity of this compound to organisms must be investigated through a series of rigorous tests. Acute toxicity tests can detect the immediate effects of short-term exposure to large amounts of it on the body. If the dose is too large, it may cause serious reactions such as breathing difficulties, convulsions, and organ damage in the tested organisms. Long-term toxicity tests are also indispensable to clarify whether long-term low-dose exposure can cause chronic diseases, organ function decline, or adverse effects on reproduction and development.
In terms of environmental effects, if this compound enters the environment, it may affect various organisms. In aquatic ecosystems, or affect the growth, reproduction and behavior of aquatic organisms, or even enrich through the food chain, causing harm to higher organisms. In soil ecosystems, or interfere with the activities of soil microorganisms, affecting soil fertility and plant growth.
In terms of its chemical stability, it is also closely related to safety. If this compound is chemically active, it is easy to react with other substances in the environment, or generate more harmful products. And if it is easy to decompose under specific conditions, the safety of the decomposition products also needs to be considered.
In addition, its safety during production, storage and transportation cannot be ignored. During production, if it is not handled properly, or it is exposed to workers, it may cause health problems. When storing, it is necessary to pay attention to whether it reacts with the storage container and whether there are strict requirements for the storage environment conditions. During transportation, it is necessary to prevent leakage, because once it leaks, it will pose a potential threat to the surrounding environment and people.
To know the safety of 2-%5B%284-Ethenylphenyl%29methyl%5D-1H-benz%5Bde%5Disoquinoline-1%2C3%282H%29-dione, it is necessary to rely on professional and detailed scientific research and testing, and comprehensive assessment from multiple dimensions to draw accurate and reliable conclusions.