(1S,3R,4S)-quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

There is a substance named\ ((1S, 3R, 4S) \) -quinine ring-3-yl 1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylate. This is one of the organic compounds with a unique chemical structure.
In this structure, the quinine ring part is a rigid cage structure with a specific spatial configuration.\ ((1S, 3R, 4S) \) indicates a stereochemical configuration at a specific location on the quinine ring, which has a great influence on the physical, chemical and biological activities of the compound.
The 1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid ester fragment is also of great significance. Phenyl is an aromatic group, which imparts certain hydrophobicity and conjugation properties to the compound; 3,4-dihydroisoquinoline ring is a nitrogen-containing heterocycle with unique electron cloud distribution and reactivity; carboxylic acid ester structure can participate in a variety of chemical reactions, and can also regulate the solubility and biological activity of molecules. Quinine ring-3-group and 1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid ester are connected by ester bonds. This connection makes the whole molecule form an organic whole, and each part affects each other to jointly determine the properties and functions of the compound. Its structure is exquisite, like a natural creation, containing the secrets and charm of chemistry.

(1S, 3R, 4S) -quinine ring-3-yl 1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid ester, this is an organic compound. Its physical properties are as follows:
Looking at its morphology, it is often in the state of white to off-white crystalline powder, which is conducive to discrimination and operation.
When it comes to the melting point, it is about 145-148 ° C. The melting point is one of the characteristics of the substance. At this temperature, the compound melts from a solid state to a liquid state. This temperature range can be used as one of the aids in determining the purity. < Br >
In terms of solubility, in organic solvents such as chloroform and dichloromethane, it shows good solubility and can be uniformly dispersed; in water, the solubility is relatively low. This difference in solubility is of great significance in the separation, purification and reaction operations of compounds.
In addition, the compound has certain stability. Under normal temperature, dry and dark environment, it can maintain its chemical structure and properties for a certain period of time. In case of extreme conditions such as strong acid, strong alkali or high temperature and high humidity, its structure may be damaged and its chemical properties will also change. < Br >
The physical properties of this compound are key factors to consider in many fields such as organic synthesis and drug development, and have guiding value for its preparation, application and storage.

(1S, 3R, 4S) -quinine ring-3-yl 1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid ester, this substance has a wide range of uses. In the field of medicine, it may have unique pharmacological activities or be a key intermediate for the development of new drugs. Because of its specific chemical structure, it may interact with specific targets in organisms, thereby regulating physiological processes and exerting therapeutic effects on certain diseases.
In the field of organic synthesis, it also occupies an important position. It can be used as a key building block to construct more complex compound structures with the help of various organic reactions, contributing to the development of organic synthesis chemistry and providing the possibility for the creation of novel organic materials.
In addition, in the chemical industry, it can be used as a special auxiliary agent to endow products with specific properties, such as enhanced stability and improved reactivity. It plays a key role in the Research & Development and Production of Fine Chemical Products and promotes the progress and innovation of chemical technology.

The synthesis of (1S, 3R, 4S) -quinine ring-3-yl 1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid esters is particularly complicated.
First, 1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid is used as the starting material, and often needs to be acylated. Choose a suitable acylation reagent, such as acid chloride or acid anhydride, and meet (1S, 3R, 4S) -quinine ring-3-ol under the catalysis of bases. The alkali, or triethylamine, pyridine and the like, can capture the acid produced by the reaction and make the reaction go smoothly to the right. The conditions for this acylation step must be carefully observed, and the temperature, the proportion of the reactants, and the length of the reaction are all important factors. If the temperature is too high, it may cause side reactions, resulting in impure products; if the ratio is improper, or the reaction is not completed, the yield will be reduced; if the time is not suitable, it will also affect the completeness of the reaction.
Furthermore, isoquinoline derivatives are used as the basis to construct the ring system of isoquinoline first, followed by the introduction of phenyl and quinine ring-3-groups. The method of constructing the isoquinoline ring system can be based on the classic Bischler-Napieralski reaction. After acylation, cyclization, reduction and other steps, 1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid intermediate was obtained, and then combined with (1S, 3R, 4S) -quinine ring-3-alcohol phase to obtain the target product.
Or there is a way to use transition metal catalysis. For example, using metals such as palladium and copper as catalysts, the halogenated isoquinoline derivatives and phenylboronic acid are coupled by Suzuki to introduce phenyl groups, and then the subsequent reaction with quinine ring-3-alcohol is carried out to obtain (1S, 3R, 4S) -quinine ring-3-yl 1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid esters. However, the method of transition metal catalysis requires strict requirements for the selection of catalysts and the collocation of ligands, and the recovery and reuse of catalysts are also considered. < Br >
Synthesis of this compound, each method has its advantages and disadvantages, and the appropriate method should be carefully selected according to the existing raw materials, equipment, and the requirements for the purity and yield of the product.

(1S, 3R, 4S) -quinine ring-3-yl 1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid ester, this compound has many applications in the field of medicine. Its related drug applications, due to its unique chemical structure and biological activity, can act on specific biological targets and regulate physiological processes.
In neurological diseases, it can regulate neurotransmitter transmission, and is expected to improve symptoms in Parkinson's disease and Alzheimer's disease. In Parkinson's disease, dopaminergic nerve cells in the brain are damaged, resulting in insufficient dopamine secretion. This compound may promote dopamine release, or enhance dopamine receptor sensitivity, relieve tremor, stiffness and other symptoms.
In the field of psychiatric diseases, such as depression and anxiety, it may act on the neurotransmitter system such as serotonin and norepinephrine to regulate mood. Depression is often caused by the imbalance of neurotransmitters. This compound may restore balance and improve the condition of low mood and loss of interest in patients.
In the field of cardiovascular diseases, it may affect ion channels and receptors, regulate heart rhythm and vascular tension. In patients with arrhythmia, the electrical activity of the heart is abnormal. This compound may correct abnormal electrical signals and restore normal rhythm. In patients with hypertension, it may dilate blood vessels, reduce peripheral resistance, and stabilize blood pressure.
In the field of pain treatment, it may act on the pain transmission pathway and inhibit pain signaling, which can be used for the relief of chronic pain and postoperative pain. Chronic pain is often caused by nerve damage or inflammation. This compound may block pain transmission and relieve patient pain.
However, the road of drug development is long. Although (1S, 3R, 4S) -quinine ring-3-yl-1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylate has potential application prospects, it still needs to undergo rigorous clinical trials to prove its safety and effectiveness before it can be widely used in clinical treatment.