1h Benz De Isoquinoline 1 3 2h Dione 2 Hydroxy
quinoline thiophene imidazole thiazole

1H-Benz(de)isoquinoline-1,3(2H)-dione, 2-hydroxy-

Taiy Chemical

    Specifications

    HS Code

    240882

    Chemical Formula C10H7NO4
    Molar Mass 205.17 g/mol
    Acidity The 2 - hydroxy group may confer some acidity
    Basicity The nitrogen in the isoquinoline ring may have weak basicity
    Reactivity Reactive towards reagents that can react with the carbonyls and hydroxy group

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    What is the chemical structure of 2-hydroxy-1H-benzo (de) isoquinoline-1,3 (2H) -dione?
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    In this compound, the naphthyl group is a thick aromatic group, which is fused from benzene, and has a definite aromaticity. In this molecule, the important skeleton part of the naphthyl group, the distribution of the sub-cloud and the empty image of the influence molecule.
    1H-indole part, the indole-containing nitrogen atom, has the characteristics of special children. The solitary system of the nitrogen atom makes the indole atom rich. This indolyl-naphthyl phase, the interaction between the two, can be changed in one step.
    And the 1,3 (2H) -diketone, the carbonyl phase is at the 1,3 position, and its existence makes the molecule have a specific anti-activity. The carbonyl group and the absorber group make the α-atomic activity of the diketone part greatly increased, and it is easy to generate reactions such as nuclear substitution and enolization. The diketone-naphthyl group and indole phase, the sub-effects of different groups are affected by each other, forming a special reaction property and space.
    Therefore, the chemical reaction of 2 + -naphthyl-1H-indole (de) -square light-1,3 (2H) -diketone is formed by the interaction of naphthyl, indole and diketone, and the interaction of each part makes the chemical compound special.
    What are the physical properties of 2-hydroxy-1H-benzo (de) isoquinoline-1,3 (2H) -dione?
    1,3 (2H) -diazine, also known as pyridazine, is a six-membered heterocyclic compound containing two nitrogen atoms, which has important applications in the fields of organic synthesis and medicinal chemistry. The following is an introduction to its physical properties:
    1. ** Appearance and Properties **: Pure pyridazine products usually appear as colorless to light yellow needle-like crystals, which exist stably in the environment of room temperature and pressure, showing a regular crystal morphology, reflecting the order of its molecular arrangement.
    2. ** Melting Point and Boiling Point **: Pyridazine has a relatively low melting point, about 29-30 ° C, which means that at close to room temperature, pyridazine can be converted from a solid state to a liquid state. Its boiling point is about 207 ° C, indicating that a higher temperature is required to convert it from a liquid state to a gaseous state. This characteristic of melting point and boiling point allows pyridazine to exhibit different physical states at different temperatures, which facilitates its application in various experiments and industrial operations.
    3. ** Solubility **: Pyridazine can be well dissolved in common polar solvents such as water, ethanol, and ether. This good solubility is derived from the electronegativity of the nitrogen atom in the molecular structure of pyridazine, which makes the molecule have a certain polarity, so that strong interaction forces can be formed with polar solvent molecules, such as hydrogen bonds, which promotes the dissolution process.
    4. ** Odor and Density **: Pyridazine has a weak pyridine-like odor, an odor characteristic that facilitates initial identification by olfaction in practical operation. Its density is about 1.07 g/cm3, which is similar to that of water. This property is significant when it comes to mixing solutions or separation processes.
    What are the main uses of 2-hydroxy-1H-benzo (de) isoquinoline-1,3 (2H) -dione?
    1,3 (2H) -diazine is a class of nitrogen-containing heterocyclic compounds. It has important uses in many fields.
    In the field of medicinal chemistry, 1,3 (2H) -diazine is often a key structural unit. Due to its unique electronic properties and spatial configuration, it can precisely bind to specific targets in organisms. Many antibacterial drugs, with the structure of 1,3 (2H) -diazine, can effectively inhibit the growth and reproduction of bacteria. For example, some new quinolone antibacterial drugs, after the introduction of this structure, the antibacterial activity is greatly increased, and it also has a good inhibitory effect on drug-resistant bacteria, because it can interfere with the function of bacterial DNA topoisomerase and block bacterial DNA replication.
    In materials science, 1,3 (2H) -diazine also plays an important role. The polymer material constructed on this basis has excellent thermal stability and mechanical properties. This structure can enhance the interaction between molecules and make the material structure more stable. For example, in high-performance composites used in the aerospace field, the addition of monomers containing 1,3 (2H) -diazine structure can improve the material's high temperature resistance and fatigue resistance, and meet the strict requirements of aircraft use.
    Furthermore, in organic synthetic chemistry, 1,3 (2H) -diazine is often used as a key intermediate. Due to its moderate structural activity, different functional groups can be introduced through various chemical reactions to achieve the construction of complex organic molecules. By reacting with nucleophiles and electrophiles, various organic compounds with special functions can be efficiently synthesized, providing an important synthesis path for the development of new functional materials and drugs.
    In summary, 1,3 (2H) -diazine is widely used in drugs, materials, organic synthesis and other fields, and is of great significance to promote the development of technologies in various fields.
    What are the synthesis methods of 2-hydroxy-1H-benzo (de) isoquinoline-1,3 (2H) -dione?
    To prepare 2-methoxy-1H-indeno (de) isoquinoline-1,3 (2H) -dione, there are various methods.
    First, the method of nucleophilic substitution can be borrowed. First, take a halogenated aromatic hydrocarbon containing an appropriate substituent and make it meet the methoxy negative ion. Methoxy negative ions can be provided by sodium methoxide or the like. The two are combined and changed by nucleophilic substitution to obtain an aromatic hydrocarbon containing methoxy. Later, the aromatic hydrocarbon is condensed with compounds with active carbonyl groups, such as dione derivatives, with the help of bases. Bases, such as potassium carbonate and potassium tert-butyl alcohol, can promote the speed of the reaction and help the two combine. After cyclization, they gradually form the framework of 2-methoxy-1H-indeno (de) isoquinoline-1,3 (2H) -dione.
    Second, or use the method of metal catalysis. Choose a suitable metal catalyst, such as a complex of palladium, copper, etc. Use alkenyl and alkynyl aromatics with methoxy sources, such as methyl borate, under metal catalysis. Metal catalysts can activate substrates and promote the breaking and formation of chemical bonds. After obtaining an intermediate with a specific structure, it is treated with an acid or base to make it cyclized within the molecule, and the final target is 2-methoxy-1H-indeno (de) isoquinoline-1,3 (2H) -dione.
    Third, we can also consider the method of cyclization addition. Select appropriate unsaturated hydrocarbons, such as conjugated dienes and bienes, which contain methoxy groups and cyclical functional groups. The two undergo Diels-Alder reaction to form intermediates with bridged rings first. After that, through appropriate chemical modification, such as oxidation, reduction, rearrangement and other steps, it is converted into 2-methoxy-1H-indo (de) isoquinoline-1,3 (2H) -dione. Each method has its advantages and disadvantages, and it needs to be selected according to the actual situation, such as the ease of raw materials, the conditions of reaction, and the high or low yield.
    What is the market prospect of 2-hydroxy-1H-benzo (de) isoquinoline-1,3 (2H) -dione?
    The market prospect of Fu 1,3 (2H) -diketone is related to many factors.
    The first to bear the brunt is that it has a wide range of uses in the field of organic synthesis. This diketone structure has good activity and is often a key building block for the construction of complex organic molecules. Chemists rely on it to synthesize various bioactive compounds, such as drugs and natural products. Nowadays, pharmaceutical research and development is in the ascendant, and there is a growing demand for compounds with specific structures and activities. As an important synthetic raw material, 1,3 (2H) -diketone may emerge in the process of new drug creation and find new paths for the treatment of many diseases. Its market potential in the pharmaceutical field cannot be underestimated.
    Furthermore, in the field of materials science, 1,3 (2H) -dione is also promising. Its unique chemical structure may endow materials with different properties. For example, it can be used to prepare materials with special optical and electrical properties. With the rapid development of science and technology, there is a great demand for new functional materials. If we can deeply explore the potential of 1,3 (2H) -dione in material synthesis and develop new materials with excellent performance, such as photoelectric materials, sensor materials, etc., it will surely be able to gain a place in the materials market.
    However, its market prospects are not smooth. The advantages and disadvantages of the synthesis process have a profound impact on its cost and quality. If the synthesis process is complicated and the yield is low, the cost will be high, which will weaken the market competitiveness. And the market competition has always been fierce, and similar or alternative products also pose challenges to it. To expand the market, it is necessary to continuously optimize the synthesis process, improve product quality, and reduce costs in order to gain a firm foothold in the market.
    In summary, although 1,3 (2H) -dione faces challenges, with its potential applications in organic synthesis and materials science, the market prospect may be very broad if it is well developed and utilized.