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What is the chemical structure of 10-Hydroxybenzo [h] quinoline?
10 - Hydroxybenzo [h] quinoline is an organic compound with a unique chemical structure. This compound contains a benzoquinoline parent nucleus with a hydroxyl group attached at position 10.
The benzoquinoline parent nucleus is formed by fusing a benzene ring with a quinoline ring. The quinoline ring is a nitrogen-containing hexamembered heterocycle fused with a benzene ring. It is aromatic and has a cyclic, conjugated and closed π electronic system because it satisfies the Shocker rule. The benzoquinoline parent nucleus endows the compound with certain stability and special chemical activity. The presence of the hydroxyl group at position 10
significantly affects its properties. The hydroxyl group is a strong electron donor group, which can affect the distribution of the parent nuclear electron cloud of benzoquinoline through conjugation and induction effects. This results in a change in the molecular charge distribution and affects its chemical reactivity. For example, the density of the electron cloud of the o and para-hydroxyl groups increases, and it is more prone to electrophilic substitution reactions, such as halogenation, nitrification, etc.
From the perspective of physical properties, the hydroxyl group can participate in the formation of intermolecular hydrogen bonds. This can enhance the intermolecular force, increase the melting point and boiling point of the compound, and may enhance the solubility in polar solvents.
In the field of chemical synthesis and medicinal chemistry, the structural characteristics of 10-Hydroxybenzo [h] quinoline make it an important intermediate. The chemical and physical properties endowed by its unique structure provide the basis for the development of new drugs, materials, etc. Scientists can modify its structure to create new compounds with specific properties.
What are the main uses of 10-Hydroxybenzo [h] quinoline
10 - Hydroxybenzo [h] quinoline, Chinese name 10 - hydroxybenzo [h] quinoline, this is an organic compound that has important uses in many fields.
In the field of materials science, it can be used as a fluorescent material. Because of its special molecular structure and electronic properties, it can emit fluorescence when excited by specific wavelengths of light. In the construction of fluorescent sensors, it can selectively respond to specific ions or molecules, and can be detected by changing the fluorescence intensity or emission wavelength. For example, it can be used to detect specific metal ions in the environment. By coordinating with metal ions, the fluorescence signal is changed, so as to achieve sensitive detection of metal ions, which is very useful in environmental monitoring.
In the field of medicinal chemistry, it may have potential biological activity. Studies have shown that some quinoline-containing structural compounds have antibacterial, anti-inflammatory, anti-tumor and other biological activities. 10-Hydroxybenzo [h] quinoline, as a quinoline derivative, or due to the presence of phenolic hydroxyl groups, imparts unique biological activity. It can interfere with cell physiological processes by interacting with specific targets in organisms, such as binding to specific enzymes or receptors, and then exert therapeutic effects on diseases, providing direction for the development of new drugs.
In the field of analytical chemistry, it can be used as an analytical reagent. In spectrophotometry, it is used to react with specific substances to generate products with characteristic absorption spectra, and the content of target substances is quantitatively analyzed by measuring absorbance. Due to its special affinity and reactivity to certain substances, it can improve the selectivity and sensitivity of analytical methods and play an important role in chemical analysis.
In summary, 10-hydroxybenzo [h] quinoline has important applications in materials science, medicinal chemistry, analytical chemistry and other fields, which is of great significance to promote the development of various fields.
What are the physical properties of 10-Hydroxybenzo [h] quinoline
10 - Hydroxybenzo [h] quinoline is an organic compound. Its physical properties are quite important and are related to many applications in chemistry and materials.
First of all, its appearance is often a crystalline solid. The crystalline shape is regular, the particles are fine, and its molecules are arranged in an orderly manner. Looking at its color, it is mostly white or almost white. This pure color often suggests its high purity and relatively simple structure.
The melting point is one of the properties of matter. 10 - Hydroxybenzo [h] quinoline has a specific melting point. When the temperature rises to a certain level, it will change from solid to liquid. The exact value of the melting point is slightly different due to the measurement conditions, but it is roughly within a certain range. This property is crucial for the identification of the substance and the assessment of purity.
In addition, the solubility is mentioned. In common organic solvents, its solubility varies. In some polar organic solvents, such as ethanol and acetone, it can exhibit some solubility, which is caused by the interaction between the molecular structure and the solvent. In non-polar solvents, such as n-hexane, the solubility is poor. This difference in solubility provides many possibilities for its separation, purification and application.
has density. Although it is not often well known to the public, it is indispensable in chemical research and engineering applications. Its density value reflects the compactness of the molecules of the substance and is related to other physical properties.
In addition, when the compound is in solid state, it may have certain hardness and brittleness, which is closely related to the intermolecular forces and crystal structure. Its physical properties interact with each other and together constitute the unique physical properties of the substance, which are of great significance in many fields such as organic synthesis, drug development, and materials science.
What are the synthesis methods of 10-Hydroxybenzo [h] quinoline
10 - Hydroxybenzo [h] quinoline is also a chemical substance. There are many ways to synthesize it, and each has its own ingenuity.
One of the methods can be started from the aqueous aldehyde of aminobenzoic acid. The two are obtained by catalysis in the appropriate solution, and the combination is reversed. Those who dissolve, such as ethanol and toluene, can be used. Catalysis can be used for acids, such as acetic acid, acid, etc., or water, depending on the product. The reverse effect of this reaction needs to be controlled, usually under the addition of water, so that the reverse effect can be achieved. For several times, the reverse effect can be obtained by the method of water extraction, such as recrystallization, column analysis, etc., to obtain 10 - Hydroxybenzo [h] quinoline.
Another method is to start with 8-quinolinol. First make it reverse and introduce a carboxyl group. This process can be formed by multi-step reverse. Or first use 8-quinolinol to obtain the medium compound, and then hydrolysis, oxidation and other steps to successfully introduce the carboxyl group. In the case of suitable components, the carboxyl group is formed at the low position, and then 10-Hydroxybenzo [h] quinoline is formed. All the ingredients used in the solution and the reverse solution need to be considered carefully before the reaction benefit and efficiency can be achieved.
Furthermore, there are those who use natural ingredients as starting materials. 10-Hydroxybenzo [h] quinoline can also be synthesized from the substances contained in certain plants or microorganisms in the steps of extraction, chemical repair, etc. This way is challenging, but you may be able to get more expensive things, and it is in line with the concept of colorization. In today's synthesis, there is no way to explore.
10-Hydroxybenzo [h] quinoline What are the precautions during use
10 - Hydroxybenzo [h] quinoline is also an organic compound. When using, many precautions must be kept in mind.
Those who bear the brunt should not be ignored for safety protection. This compound may be toxic and irritating to a certain extent. When exposed, be sure to wear suitable protective equipment. For example, wear protective gloves to prevent it from coming into direct contact with the skin, causing skin damage, rash and itching may occur; wear protective glasses, if accidentally splashed into the eyes, it may cause serious damage to the eyes and even affect vision.
Furthermore, its storage is also exquisite. It should be placed in a cool, dry and well-ventilated place. If the storage environment is improper, such as high temperature and humidity, or improper mixing with other chemicals, it may cause chemical reactions, cause deterioration, affect the use effect, or even be dangerous.
During use, precise operation steps are essential. It needs to be carried out according to the established experimental procedures or production process, and must not be changed without authorization. When weighing, use a precision measuring tool to ensure that the dosage is accurate. Too much or too little dosage may affect the reaction process or product quality.
In addition, it is also necessary to operate in a fume hood. Because of the use or volatilization of harmful gases, if there is no good ventilation, harmful gases accumulate and are inhaled into the human body, which is harmful to health.
And after use, proper disposal of residues and waste should not be ignored. It should not be dumped at will, but should be treated harmlessly in accordance with relevant environmental regulations to avoid polluting the environment. In this way, when using 10-Hydroxybenzo [h] quinoline, it can not only achieve the intended purpose, but also ensure safety and the environment.
