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What is the chemical structure of 10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2, 3-dihydro-7H- [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid?
This is the name of 10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid. To clarify its chemical structure, let me tell you in detail.
Looking at this name, it can be seen that this compound has quinoline as the core parent nucleus. Quinoline is a nitrogen-containing heterocyclic aromatic hydrocarbon. In the sixth position of the quinoline parent nucleus, there is a carboxyl group, which gives the compound certain acidic properties. < Br >
Its 7-position is an oxo group, that is, a carbonyl group, which has a great influence on the electron cloud distribution and chemical activity of the compound. The 2,3-position is a dihydrogen structure, which reduces the double bond of this part, thereby changing the spatial configuration and stability of the molecule.
Looking at the 9-position, there are fluorine atoms, which are extremely electronegative and have a significant effect on the lipophilicity and biological activity of the compound after introduction. The 3-position has a methyl group. Although the methyl group is relatively simple, it also contributes to the steric resistance and hydrophobicity of the molecule. < Br >
The most special one, 10-bit linkage (1-aminocyclopropyl), cyclopropyl structure is unique, its tension is large, and it has a profound impact on the overall activity and conformation of the molecule. The amino group itself can participate in a variety of chemical reactions, adding many reactive activity check points to the compound.
In summary, the chemical structure of this compound is cleverly combined by the quinoline parent nucleus and many substituents, and the interaction of each part determines its unique chemical and biological properties.
What are the physical properties of 10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2, 3-dihydro-7H- [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid
10- (1-Aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid, this is an organic compound. Its physical properties are quite critical and related to many fields of application.
Looking at its morphology, it is often solid or crystalline at room temperature and pressure, just like exquisite jade, with a regular geometry. This is due to its intermolecular forces and orderly arrangement. The melting point of
is also an important property. At a specific temperature, the compound will change from solid to liquid, just like ice and snow melting. This melting point value is a key indicator for accurately characterizing its thermal stability, which is of great significance for processing and storage.
Solubility cannot be ignored. In water, its solubility may be limited, just like a lone boat overflowing the vast river surface, making it difficult to completely blend. However, in some organic solvents, such as some polar organic solvents, it can be well dissolved, like a fish getting water, which is due to the interaction between molecules and solvents.
In addition, its density also has a fixed number, reflecting the mass of the substance contained in a unit volume, just like a ruler to measure the "thickness" of an object, which has a great impact on its distribution and behavior in different media.
The physical properties of the compound, such as morphology, melting point, solubility, density, etc., are of great significance in many fields such as chemical industry and medicine, or affect the reaction process, or affect the efficacy of drugs, which is the key to research and application.
What is the main use of 10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2, 3-dihydro-7H- [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid
10- (1-Aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid, this is a chemical substance with a wide range of uses.
In the field of medicine, it is often a key intermediate for the synthesis of specific antibacterial drugs. Antibacterial drugs can effectively fight a variety of bacterial infections, inhibit bacterial growth or directly kill bacteria, and escort human health. The synthetic antibacterial drugs involved in this substance are effective in treating diseases such as respiratory tract infections, urinary system infections, and skin and soft tissue infections. By precisely acting on specific targets of bacteria and interfering with the normal physiological metabolism of bacteria, the purpose of antibacterial is achieved.
In the field of chemical research, this substance acts as an important intermediate, which helps scientists to deeply explore the synthesis pathways and properties of new compounds. Through structural modification and modification, new compounds with unique properties and functions can be developed, contributing to the development of chemistry. These new compounds may show potential application value in materials science, drug development and other fields, and promote technological innovation and progress in related fields.
What are the synthesis methods of 10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2, 3-dihydro-7H- [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid
The synthesis of 10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid is an important research in the field of organic synthetic chemistry. Now in ancient Chinese, the details are as follows.
One method, or follow the classical cyclization condensation path. First take the appropriate fluoroquinoline derivative, which needs to have a specific substituent to lay the foundation for the subsequent reaction. Mix it with a reagent containing amino cyclopropyl group in a suitable organic solvent. This organic solvent, when it has good solubility and stability, such as dichloromethane, N, N-dimethylformamide, etc. Then, add an appropriate amount of condensing agent, such as dicyclohexyl carbodiimide (DCC), etc., to promote the condensation reaction between the two. The reaction temperature needs to be carefully regulated. Initially, it can be initiated at a low temperature, and gradually heated to a moderate temperature to make the reaction proceed smoothly. After this step, it is expected to form a preliminary skeleton structure. The
secondary method may also start with the construction of oxazine rings. Select specific amino phenols, react with halogenated hydrocarbons with suitable substituents, and introduce key substituents. Then, the resulting product is reacted with cyclopropylamine derivatives under alkaline conditions. This alkaline condition can be created by alkaline substances such as sodium hydroxide and potassium carbonate. The strength and reaction time of alkalinity have a great influence on the reaction process and product purity. During the reaction process, stirring may be required to facilitate full contact of the reactants. After a series of reactions, the construction of the oxazine ring is realized, and the target product precursor is obtained. After appropriate oxidation and deprotection steps, 10 - (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid is finally obtained.
Furthermore, there is still a strategy. First prepare active esters containing fluoroquinoline-6-carboxylic acids, such as those formed with p-nitrophenol. The active ester is reacted with a nucleophilic reagent of 1-aminocyclopropyl group, and the nucleophilic reagent attacks the carbonyl carbon of the active ester to achieve the introduction of the aminocyclopropyl group. After that, the oxazine ring structure is constructed through an intramolecular cyclization reaction. This cyclization reaction may require the participation of specific catalysts, such as Lewis acid. The type and dosage of catalysts need to be carefully considered in order to make the reaction efficient and obtain the desired product. Each method has its own advantages and disadvantages, and it needs to be weighed according to the actual situation.
What is the competitive advantage of 10- (1-aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2, 3-dihydro-7H- [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid in the market?
10- (1-Aminocyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid, this is a rather unique class of compounds. In today's market, its competitive advantages are manifested in many aspects.
The first to bear the brunt is its excellent antibacterial efficacy. This compound has significant inhibition and killing power against many pathogens, and can effectively deal with a variety of infectious diseases. It is of great significance in the field of medicine. Looking back at the past, many good medicines for treating diseases and saving people have been handed down due to their remarkable efficacy. This compound is also expected to occupy a place in the antimicrobial drug market by virtue of this characteristic.
Furthermore, its chemical structure is unique. This uniqueness gives it more excellent pharmacokinetic properties than similar drugs, such as better absorption, distribution, metabolism and excretion characteristics, which can more efficiently reach the target of action and exert its efficacy. In the past, the exquisite prescriptions relied on the unique compatibility and characteristics. The unique structure of this compound is just like that unique compatibility, making it stand out in the competition.
In addition, developers have invested a lot of effort in it, and the research and development technology is advanced. With advanced technology, the product quality can be guaranteed to be stable and controllable, and the production efficiency can also be improved, thus having a unique advantage in cost control. Just like the sophisticated production process in ancient times, which can produce high-quality products, this compound is supported by advanced technology and has more confidence in market competition.
However, the market competition is very fierce. Although this compound has the above advantages, if it wants to gain a long-term foothold, it still needs to continue to improve and meet the challenges of all parties, in order to leave a strong mark in the pharmaceutical market like the classic ancient recipe.