1 S 6 S 1 Cyclopropyl 7 2 8 Diazabicyclo 4 3 0 Non 8 Yl 6 Fluoro 8 Methoxy 4 Oxo 1 4 Dihydroquinoline 3 Carboxylic Acid Hydrochloride
Quinoline Thiophene Imidazole Thiazole
(1's,6's)-1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
Chemical Name (1's,6's)-1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
Molecular Formula C21H26ClFN3O4
Molecular Weight 437.899 g/mol
Appearance Solid (predicted)
Solubility Soluble in organic solvents (predicted)
Pka (Relevant acidic or basic pKa values if available, prediction can be made based on functional groups)
Melting Point (Predicted melting point range)
Boiling Point (Predicted boiling point range)
Logp (Predicted octanol - water partition coefficient value)
Chemical Structure (Describe the general ring and side - chain structure of the molecule)
Isomeric Form (1's,6's) - indicating specific stereochemistry
FAQ

What is the chemical structure of (1's, 6's) -1-cyclopropyl-7- (2,8-diazabicyclo [4.3.0] non-8-yl) -6-fluoro-8-methoxy-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid hydrochloride

(This is the name of a chemical substance, which needs to be converted into a chemical structure description, and answered in ancient classical Chinese style)

This " (1's, 6's) -1 -cyclopropyl-7- (2,8 -diazabicyclo [4.3.0] Non- 8 -yl) -6 -fluoro-8 -methoxy-4 -oxo-1,4 -dihydroquinoline-3 -carboxylic acid, hydrochloride", its chemical structure is described as follows:

on the quinoline parent nuclear structure, at 1 position, connected by a ring Propyl group, and the configuration is (1's); fluorine atoms are introduced at the 6th position, in the (6's) configuration; methoxy group is added at the 8th position; oxo group is added at the 4th position, which constitutes the part of 1,4-dihydroquinoline. At the 3rd position, the carboxylic group is where the carboxylic acid is located. At the 7th position, there are 2,8-diazabicyclo [4.3.0] non-8-groups. And because it is a hydrochloride salt, it shows that this compound forms a salt with hydrochloric acid, that is, there are parts in the molecule that bind to hydrochloric acid, and the whole forms a unique chemical structure. This structure fuses multiple functional groups with specific ring systems, and each part is connected to each other, giving the substance specific chemical properties and reactivity.

What are the main uses of (1's, 6's) -1-cyclopropyl-7- (2,8-diazabicyclo [4.3.0] non-8-yl) -6-fluoro-8-methoxy-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid hydrochloride

(1 ′ s, 6 ′ s) -1-cyclopropyl-7- (2,8-diazabicyclo [4.3.0] non-8-yl) -6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride, this is a chemical substance. It has a wide range of uses and is often used as an antibacterial drug in the field of medicine, showing excellent efficacy in many bacterial infections. Due to its special chemical structure, it can efficiently inhibit the growth and reproduction of bacteria, and has a unique mechanism of action. It interferes with the key metabolic processes or structures of specific bacteria, thus achieving the purpose of antibacterial.

In the field of scientific research, this compound is an important research object, which helps researchers to deeply explore the principle of action of antibacterial drugs and the mechanism of bacterial resistance. Through its research, it may be possible to develop more efficient and safe antibacterial drugs, contributing to human health and well-being.

Furthermore, in the process of drug development, this substance may act as a lead compound, providing key ideas and directions for the design and synthesis of new antibacterial drugs. Researchers can improve the antibacterial activity of drugs, reduce toxic and side effects, and develop better drug varieties by modifying and optimizing their structures. In conclusion, (1 ′ s, 6 ′ s) -1-cyclopropyl-7- (2,8-diazabicyclo [4.3.0] non-8-yl) -6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride is of great significance in the fields of medicine and scientific research.

What is the synthesis method of (1's, 6's) -1-cyclopropyl-7- (2,8-diazabicyclo [4.3.0] non-8-yl) -6-fluoro-8-methoxy-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid hydrochloride

The synthesis of (1'S, 6'S) -1-cyclopropyl-7- (2,8-diazabicyclo [4.3.0] non-8-yl) -6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride is involved in the field of organic synthesis. The synthesis steps are complex and delicate, and it is necessary to describe in detail.

The choice of starting materials is crucial. Often based on quinoline derivatives with specific structures, this derivative needs to contain a modifiable check point to facilitate subsequent reactions. If a specific substituted 4-oxo-1,4-dihydroquinoline-3-carboxylic acid is selected, its cyclopropyl, fluorine atom, methoxy group and other parts may already exist in the starting material, or may be introduced by subsequent reactions.

When introducing cyclopropyl, or using cyclopropyl halide and corresponding nucleophilic reagents in suitable bases and solvents, it is formed by nucleophilic substitution reaction. This reaction requires strict control of reaction conditions, such as temperature and amount of base, to ensure that cyclopropyl is accurately connected to the target position and to avoid side reactions.

The introduction of 7 (2,8-diazabicyclo [4.3.0] non-8-yl) is more complicated. Or the bilicyclic structure can be constructed through a multi-step reaction. First, a suitable amine compound is reacted with a halogenated hydrocarbon to initially form a nitrogen-containing chain intermediate, and then it is cyclized within the molecule to construct a bilicyclic structure. During this period, attention should be paid to the regulation of the reaction sequence and conditions, so that the reaction can proceed according to the design path.

As for 6-fluorine and 8-methoxy groups, they may already exist in the starting material, or they can be introduced by fluorination reaction and methoxylation reaction respectively. The fluorination reaction is often reacted with a specific fluorination reagent under a specific solvent and catalyst; the methoxylation is achieved with a methoxylation reagent according to the appropriate reaction conditions.

After the construction of the key structure is completed, the salt is finally formed to obtain hydro The obtained quinoline carboxylic acid derivatives were treated with suitable hydrochloric acid solution, and the reaction conditions were controlled to precisely form salts to obtain the target product (1 'S, 6' S) -1-cyclopropyl-7- (2,8-diazabicyclo [4.3.0] non-8-yl) -6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride. Each step of the reaction requires fine operation and strict monitoring to achieve the ideal yield and purity.

What are the pharmacological properties of (1's, 6's) -1-cyclopropyl-7- (2,8-diazabicyclo [4.3.0] non-8-yl) -6-fluoro-8-methoxy-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid hydrochloride

(1's, 6's) -1-cyclopropyl-7- (2,8-diazabicyclo [4.3.0] nonyl-8-yl) -6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride, this is a special compound. Its pharmacological properties are quite critical, related to the efficacy and properties of medicinal use.

Looking at its antibacterial properties, this compound exhibited significant inhibitory effects on many bacteria. In the category of Gram-positive and negative bacteria, it can play a role. Its mechanism of action is to interfere with the DNA replication process of bacteria, making it difficult for bacteria to multiply normally. Just like in the ancient art of war, cutting off the enemy's grain and grass, making it difficult to sustain its combat power.

Let's talk about its absorption and distribution. After taking this medicine orally, it can be absorbed from the gastrointestinal tract relatively quickly, and then widely distributed in various tissues and body fluids of the body. Like a messenger, it can arrive at the place where it needs to be used in time to ensure that the drug can attack the bacteria throughout the body.

When talking about metabolism and excretion, this compound is mainly excreted in urine after a series of metabolic reactions in the body. Like water carrying away dirt, it ensures the orderly replacement of drug ingredients in the body to avoid excessive accumulation and adverse effects.

The pharmacological properties of this compound are unique in the field of antimicrobial drugs and may play a unique role in the treatment of diseases.

(1's, 6's) -1-cyclopropyl-7- (2,8-diazabicyclo [4.3.0] non-8-yl) -6-fluoro-8-methoxy-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid hydrochloride

Now this " (1's, 6's) -1 -cyclopropyl-7- (2,8 -diazabicyclo [4.3.0] non- 8 -yl) -6 -fluoro-8 -methoxy-4 -oxo-1,4 -dihydroquinoline-3 -carboxylic acid, hydrochloride", its market prospects are quite promising.

This compound may emerge in the field of medicine. Due to the research and development of medicine, new agents are constantly sought to treat various diseases. Such quinoline carboxylic acid derivatives containing specific structures may have unique pharmacological activities. Its cyclopropyl, diazabicyclic and other structures may enhance its affinity with biological targets, thus demonstrating excellent antibacterial, anti-inflammatory or anti-tumor effects. In terms of antibacterial, there are more and more drug-resistant bacteria today, and the need for new antibacterial agents is urgent. If this compound can break the drug resistance situation, it must be important for the clinic, and the market prospect is broad.

Furthermore, the progress of research and development is also related to its market fate. If it has entered clinical trials, and the data are good, and the safety and efficacy are both available, it is expected to be approved for listing. Once listed, with its novel structure and potential efficacy, it may be able to gain a place in the highly competitive pharmaceutical market, win the favor of pharmaceutical companies, put it into mass production, and then occupy a certain market share.

However, there are also challenges. The cost of research and development is high, and the risk of clinical trials is high. If there are problems such as adverse reactions in the trial, the research and development may be blocked, which will affect its market advancement. And the market competition is fierce, and similar drugs may have been preconceived. This compound needs to highlight its advantages in order to stand out and develop market prospects.