1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxo-quinoline-3-carboxylic acid

This is the description of the chemical nomenclature, corresponding to the complex and delicate chemical structure. 1-cyclopropyl-8- (difluoromethoxy) -7- [ (1R) -1-methyl-2,3-dihydro-1H-isoindol-5-yl] -4-oxo-quinoline-3-carboxylic acid, the core of which is quinoline carboxylic acid structure.
Quinoline ring as the base frame, on the 1-position ring propyl, just like adding a ring support to the solid foundation stone to stabilize its structure. 8-Position difluoromethoxy, which imparts unique properties and affects molecular polarity and reactivity. 7-Position connected [ (1R) -1-methyl-2,3-dihydro-1H-isoindol-5-yl], is a chiral isoindoline derivative, and the chiral structure is of great significance in drug activity and selectivity. 4-Position carbonyl, that is, -4-oxo, participates in a variety of reactions, changes the distribution of electron clouds, and affects the overall stability and reaction tendency of molecules. The 3-carboxylic acid is acidic and can participate in acid-base reactions, which has a profound impact on molecular solubility and interactions with other substances.
In this way, each group is cleverly connected to construct the unique chemical structure of the compound, and each part works together to endow it with specific physical and chemical properties and potential biological activities, which may be of important value in the field of chemistry and medicine research.

1-Cyclopropyl-8- (difluoromethoxy) -7- [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl] -4-oxyquinoline-3-carboxylic acid, which is a chemical substance with a wide range of uses.
In the field of medicine, it is often a key component of antibacterial drugs. Through its specific chemical structure, it inhibits key metabolic processes or biosynthetic pathways in bacteria, effectively kills or inhibits bacterial growth, and then treats various infections caused by bacteria. Due to its unique structure, it also exhibits good antibacterial activity against some drug-resistant bacteria, and plays an important role in the development and treatment of anti-infective drugs.
In the field of chemical research, as an important organic synthesis intermediate, researchers can synthesize a series of derivatives with different properties and functions by modifying and modifying their structures. By studying the chemical properties and biological activities of these derivatives, the theoretical understanding of organic chemistry can be expanded, and the foundation for the development of new drugs and materials can be laid. In terms of the mechanism of organic synthesis reactions, the reactions carried out with them as raw materials can help scientists deeply understand various chemical reaction processes and promote the progress of organic synthetic chemistry.
In the field of materials science, after specific treatment and modification, materials may be endowed with unique properties. For example, the introduction of this compound into certain polymer materials may enhance the antibacterial properties and stability of the material, making it widely used in fields with demanding performance requirements, such as medical and health care and food packaging.

1-Cyclopropyl-8- (difluoromethoxy) -7- [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl] -4-oxo-quinoline-3-carboxylic acid, the synthesis method of this compound is as follows:
The initial raw material selects a quinoline derivative with a specific structure, and this derivative needs to contain an activity check point that can be modified to introduce cyclopropyl, difluoromethoxy and isoindole. First, in a suitable reaction vessel, a specific location of the quinoline derivative is activated with an alkaline reagent, so that the electron cloud density at this location increases and the nucleophilicity is enhanced. Subsequently, cyclopropylation reagents are slowly added dropwise. At a specific temperature and reaction time, nucleophilic substitution occurs, and cyclopropyl is successfully introduced into the quinoline skeleton.
After the introduction of cyclopropyl is completed, the pH of the reaction system is adjusted, and then difluoromethoxylation reagents are added. This process requires strict control of reaction conditions, such as temperature, solvent polarity, etc., to promote difluoromethoxy to replace specific hydrogen atoms and accurately connect to the target location.
The last step is to introduce [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl] at position 7. First, the related precursor of (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl is activated to make it a highly active electrophilic reagent. The active precursor was then added to the quinoline derivative reaction system containing cyclopropyl and difluoromethoxy, and the target structure was successfully constructed at 7 positions through electrophilic substitution or other appropriate reaction mechanisms. After the reaction, high purity 1-cyclopropyl-8- (difluoromethoxy) -7- [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl] -4-oxo-quinoline-3-carboxylic acid can be obtained by conventional separation and purification methods such as extraction and column chromatography. Structural characterization and purity analysis of the intermediate are required at each step to ensure that the reaction proceeds according to the expected path, so that the target product can be efficiently synthesized.

1-Cyclopropyl-8- (difluoromethoxy) -7- [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl] -4-oxo-quinoline-3-carboxylic acid, this is an organic compound. Its physical and chemical properties are quite important, related to its application in many fields.
First talk about the appearance. At room temperature and pressure, this compound is mostly solid, and the specific color may vary due to differences in purity. The pure product is usually white to off-white crystalline powder with fine texture. < Br >
In terms of solubility, because its structure contains polar groups and non-polar parts, it exhibits a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide. In water, the solubility is relatively small, due to the limited polarity of water molecules and the polar matching of the compound.
Melting point is also a key physical property. Experimentally determined, its melting point is in a specific temperature range. This temperature range is of great significance for the identification and purification of the compound, and it is an important index for quality control.
From the perspective of chemical properties, there is a carboxyl group in the molecule, which is acidic and can neutralize with bases to form corresponding carboxylate. At the same time, the structure of the quinoline ring and the isoindole ring is stable, but under specific conditions, it can participate in the electrophilic substitution reaction and introduce other functional groups on the ring, providing a variety of possibilities for organic synthesis.
Furthermore, the difluoromethoxy group contained in this compound endows it with unique chemical activity. The fluorine atom has a large electronegativity, which affects the distribution of molecular electron cloud, changes the reactivity and selectivity, and may have special biological activity and pharmacological effects in the field of drug synthesis. The physical and chemical properties of this compound lay the foundation for its application in organic synthesis, drug research and development and other fields.

1-Cyclopropyl-8- (difluoromethoxy) -7- [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl] -4-oxo-quinoline-3-carboxylic acid This chemical structure-related drug product is a quinolone antibacterial drug. Guanfu such compounds have the characteristics of broad antibacterial spectrum and strong activity.
In the field of medicine, many drugs developed on this basis are quite effective in anti-infection. For example, levofloxacin, although the chemical structure is different from it, they all belong to the quinolone family. It inhibits bacterial DNA rotatase or topoisomerase IV as the mechanism of action, and has good antibacterial activity against Gram-positive and negative bacteria. It is commonly used in clinical treatment of infections of the respiratory tract, urinary tract and other parts.
Another example is moxifloxacin, which is also a quinolone antibacterial drug. It also has significant activity against anaerobic bacteria, atypical pathogens, etc. It plays an important role in the treatment of diseases such as lung infections. Due to the chemical structure of quinolones, it gives it the ability to bind to bacteria-related enzymes, thereby interfering with bacterial nucleic acid synthesis and achieving antibacterial purposes. The specific structure of 1-cyclopropyl-8- (difluoromethoxy) -7- [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl] -4-oxo-quinoline-3-carboxylic acid has unique performance in terms of antibacterial activity, antibacterial spectrum and pharmacokinetic properties, which provides the possibility for the development of new and efficient antibacterial drugs.