1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

This is the chemical name of 1-cyclopropyl-8- (difluoromethoxy) -7- [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid. To clarify its chemical structure, follow the principles of organic chemistry and analyze it by name.
"1-cyclopropyl", indicating that the cyclopropyl group is attached to the first position of the parent nucleus. Cyclopropyl is a group with a ternary carbon ring. Its ring has a special tension and often shows unique activity in organic reactions.
"8- (difluoromethoxy) " means that the difluoromethoxy group is connected to the 8 position of the parent nucleus. Difluoromethoxy contains a fluorine atom, and fluorine has strong electronegativity. The introduction of this group can change the physical and chemical properties of the compound such as polarity and lipophilicity.
"7- [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl]", indicating that (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl is connected at the 7-position. This part contains isoindole structure, and the 1 position has methyl substitution, has a chiral center, and is of the R configuration.
"4-oxo-1,4-dihydroquinoline-3-carboxylic acid", revealing that the parent nucleus is 1,4-dihydroquinoline, with 4 aerobic groups and 3 carboxyl groups. Quinoline structures are widely found in many bioactive molecules and drugs, and this parent nucleus endows the compound with specific pharmacological activity potential.
In summary, the chemical structure of this compound is composed of cyclopropyl, difluoromethoxy, and chiral isoindole groups connected to the parent nucleus of dihydroquinoline and connected to carboxyl groups at 3 positions. Its complex structure contains various chemical properties and potential biological activities, which may be of important value in the field of drug development and other fields.

1-Cyclopropyl-8- (difluoromethoxy) -7- [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid, this is an organic compound. Its physical properties are quite characteristic, let me tell them one by one.
Looking at its properties, under normal circumstances, it is mostly white to light yellow crystalline powder. This powder has a fine texture and is slightly shiny in sunlight. The range of its melting point is quite critical. After rigorous determination, it is between 190 and 195 degrees Celsius. When the temperature gradually rises to the melting point, the substance slowly melts from the solid state to the liquid state. This process requires specific heat to reflect the characteristics of its intermolecular forces.
Solubility is also an important physical property. In common organic solvents, such as dimethyl sulfoxide (DMSO), it exhibits good solubility and can be quickly dispersed to form a uniform solution. In water, the solubility is relatively low and only slightly soluble. This difference is due to the fact that the molecular structure of the compound has both lipophilic parts and certain hydrophilic groups, which make it behave differently in different polar solvents.
In addition, the density of this compound also has a specific value. Although accurate measurement requires special equipment, it can be roughly known that its density is similar to that of common organic compounds, reflecting the degree of close packing of its molecules. Its appearance and morphology are similar to many similar structural compounds, but its unique physical properties such as melting point and solubility make it distinguishable from many compounds, providing an important basis for applications in chemical research, drug synthesis and other fields.

1-Cyclopropyl-8- (difluoromethoxy) -7- [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid, this is an organic compound. Its main use involves the field of medical drug development.
In the creation of antibacterial drugs, such compounds often have unique antibacterial activities. Their structural properties give them the ability to combine with specific bacterial targets, which can effectively inhibit bacterial growth and reproduction. For example, it can interfere with key life processes such as bacterial DNA replication, transcription and protein synthesis, just like a precise sharp blade, directly hitting the key bacteria, so as to achieve antibacterial effect. The development of many new quinoline antibacterial drugs is often based on such structures, modified and optimized to improve the antibacterial spectrum, enhance the antibacterial efficacy, and reduce the side effects on the human body.
Furthermore, in pharmaceutical chemistry research, this compound acts as an important intermediate, laying the foundation for the synthesis of more complex molecules with specific biological activities. Chemists explore the relationship between structure and activity by modifying and deriving its structure, just like searching for treasures in the palace of chemistry, tapping for potential therapeutic value, and finding new hope and paths to solve problems such as infectious diseases.

1-Cyclopropyl-8- (difluoromethoxy) -7- [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid, the synthesis method of this product is multi-terminal.
First, quinoline carboxylic acid derivatives are used as starting materials and are prepared by multi-step reaction. First take the appropriate quinoline carboxylic acid precursor, under specific conditions, the cyclopropyl group is connected to it. In this step, you need to choose the appropriate base and reaction solvent, or use potassium carbonate in acetonitrile, heat up and stir to achieve a good yield.
The second is the introduction of difluoromethoxy, which can be obtained by the nucleophilic substitution reaction of halogenated alkanes and difluoromethanols. First prepare difluoromethoxides, and then react with halogenated quinoline derivatives in the presence of a phase transfer catalyst. For example, tetrabutylammonium bromide is used as a catalyst to react in toluene solvent, and difluoromethoxy can be successfully introduced.
As for the [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl] part of the 7th position, (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-halide can be synthesized first, and then linked to quinoline derivatives through a palladium-catalyzed coupling reaction. Palladium acetate is selected as the catalyst, and the ligand is assisted by Xantphos. It is heated in a suitable base and solvent system, such as potassium tert-butyl alcohol and dioxane system, to achieve precise connection.
Or starting from the construction of the quinoline ring, with appropriate aniline derivatives and carbonyl-containing compounds, through multi-step cyclization, the quinoline skeleton is first formed, and then cyclopropyl, difluoromethoxy and (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl are gradually introduced. Substituents such as (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl can also be obtained by finely adjusting the reaction conditions according to the activity and reaction characteristics of the substituents.

1-Cyclopropyl-8- (difluoromethoxy) -7- [ (1R) -1-methyl-2,3-dihydro-1H-isoindole-5-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid, this is a chemical substance, related to its Quality Standards, the following items are commonly considered:
- ** Characters **: Its appearance should be carefully observed to see if it is the expected color and shape. For example, or white to off-white crystalline powder, if the color is too dark, variegated or abnormal in shape, it may suggest the presence of impurities or poor quality.
- ** Identification **: A variety of spectral means can be used, such as infrared spectroscopy, the characteristic absorption peak should be highly consistent with the standard map, just like the ancients used the map to identify the authenticity of the object; high performance liquid chromatography can also be used, and the retention time should be consistent with the reference substance, just like according to Tuosoji, to ensure that the substance is accurate.
- ** Related substances **: This is a key indicator to detect the amount of impurities. By high performance liquid chromatography, the impurity content can be accurately determined. Excessive impurities, or damage the purity and quality of the material, just like ancient utensils, more impurities affect its performance and value. Generally, specific impurities must not exceed a certain proportion, and total impurities also have corresponding limits.
- ** Content Determination **: High-performance liquid chromatography is commonly used to accurately determine the content of the substance in the sample to determine whether it meets the specified standard. Insufficient content, or difficult to meet the needs of use, like forging weapons, improper material proportions affect its function.
- ** Loss on Drying **: Determine the reduced quality of the sample after drying, reflecting the moisture and volatile impurity content. Too much moisture, or cause material deterioration and stability reduction, similar to ancient books, is easily damaged by moisture. Usually set a drying weight loss limit to ensure that the material dries up to standard.
- ** Burning residue **: After high temperature burning, measure the remaining non-volatile inorganic impurities. Too much residue indicates that the sample contains more inorganic impurities, which will interfere with the properties of the material, just like the ancient paper contains too many impurities that affect its preservation and reading. It is necessary to control the burning residue within a certain range.