1-cyclopropyl-6-fluoro-8-methoxy-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid?

This is the chemical name of a derivative of ciprofloxacin. To understand its chemical structure, let me say the following:

This compound belongs to the quinoline carboxylic acid class. Looking at its name "1 - cyclopropyl - 6 - fluoro - 8 - methoxy - 7 - [ (4aS, 7aS) - octahydro - 6H - pyrrolo [3,4 - b] pyridin - 6 - yl] - 4 - oxo - 1,4 - dihydroquinoline - 3 - carboxylic acid", "1 - cyclopropyl" shows that there is a cyclopropyl group attached to the quinoline ring at the first position. This cyclopropyl group seems to be a small ring attached to the quinoline parent nucleus, which affects the spatial structure and physicochemical properties of the compound. " The introduction of fluorine atoms at the 6-fluoro "table 6 position has high electronegativity, which can enhance the lipophilicity of molecules and has a great impact on their biological activities." 8-methoxy "means that the 8-position is connected with a methoxy group, and the electron cloud density of the quinoline ring may be changed by the electron supply effect of the methoxy group.

"7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl]" indicates that the 7-position has a specific stereoconfiguration (4aS, 7aS) octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl side chain, which has a complex structure and is of great significance for the interaction between compounds and targets. "4-oxo-1,4-dihydroquinoline" describes the quinoline ring moiety as 1,4-dihydro and the 4-position carbonyl group, which can participate in hydrogen bond formation and other interactions. "3-carboxylic acid" indicates that the 3-position is a carboxylic group, which is acidic and can be ionized under physiological conditions, which affects the solubility and pharmacological activity of the compound.

Overall, the chemical structure of this compound is composed of a quinoline parent nucleus and many different substituents. The interaction of each substituent together determines the unique chemical and biological properties of the compound.

What are the physical properties of 1-cyclopropyl-6-fluoro-8-methoxy-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid?

1-Cyclopropyl-6-fluoro-8-methoxy-7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid, this is the name of the chemical substance. Its physical properties are related to many external and internal properties of the substance, and are of great significance for chemical research and practical applications.

In terms of appearance, this substance is often in the state of white to light yellow crystalline powder, which is delicate and uniform, and has a pure texture. Its color and morphology characterize the purity and crystal structure of the substance, which is crucial for the subsequent preparation process and quality control.

In terms of solubility, the solubility in water is relatively limited. Due to the fact that the molecular structure contains more hydrophobic groups, the interaction with water molecules is weak. However, in some organic solvents, such as methanol, ethanol, and dimethyl sulfoxide, it exhibits good solubility. This property is of great significance for selecting the appropriate solvent to prepare the solution dosage form during drug development.

Melting point is also an important physical property. The melting point of the substance is about a specific temperature range. This property can not only be used to identify the purity of the substance, but also is indispensable for controlling temperature conditions and ensuring the stability and consistency of the substance during drug synthesis and preparation. < Br >
In terms of stability, under normal conditions, this substance has certain stability. However, in extreme environments such as strong acids, strong bases or high temperatures and high humidity, the molecular structure may change, triggering chemical reactions that reduce activity or produce impurities. This requires that during storage and use, attention must be paid to the control of environmental conditions. The physical properties of 1-cyclopropyl-6-fluoro-8-methoxy-7-[ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acids, from appearance, solubility, melting point to stability, are interrelated and have far-reaching effects. They play a pivotal role in the research, production and application of chemistry and drug-related fields.

What is 1-cyclopropyl-6-fluoro-8-methoxy-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid used for?

1-Cyclopropyl-6-fluoro-8-methoxy-7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid, the name of the chemical substance, which is often known as "gatifloxacin". Gatifloxacin is widely used in the field of medicine.

It is a quinolone antibacterial drug with extraordinary effects. By inhibiting the activity of bacterial DNA rotatase (bacterial topoisomerase II) and topoisomerase IV, it can interfere with the process of bacterial DNA replication, transcription and repair, and then kill bacteria.

In clinical practice, gatifloxacin is widely used. It has strong antibacterial activity against Gram-positive bacteria, such as Streptococcus pneumoniae, Staphylococcus aureus, and Gram-negative bacteria, such as Escherichia coli and Haemophilus influenzae. Therefore, it is often used to treat a variety of infectious diseases, such as respiratory tract infections, including community-acquired pneumonia, acute episodes of chronic bronchitis, etc.; urinary system infections, such as pyelonephritis, cystitis, etc.; and skin and soft tissue infections.

However, caution is also required when using gatifloxacin. Because it may cause several adverse reactions, such as gastrointestinal reactions, nausea, vomiting, diarrhea and other symptoms; it may also affect blood sugar metabolism, resulting in abnormal blood sugar fluctuations, so diabetic patients need to closely monitor blood sugar when taking medication. And it is contraindicated in those who are allergic to quinolones.

In short, gatifloxacin, as an important antibacterial drug, can play a key role in the treatment of many infectious diseases under reasonable use. However, it is necessary to pay attention to its scope of application and adverse reactions to ensure the safety and effectiveness of medication.

1-cyclopropyl-6-fluoro-8-methoxy-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid What are the synthesis methods?

1-Cyclopropyl-6-fluoro-8-methoxy-7- [ (4aS, 7aS) -octahydro-6H-pyrroso [3,4-b] pyridine-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid, which is a rather complex organic compound. Its synthesis methods are diverse, and it is described in ancient methods today.

First, the selection of raw materials is the key. Quinoline derivatives with specific substituents are often used as starting materials, such as quinoline carboxylic acids containing suitable fluorine and methoxy substitutions. Such raw materials may be commercially available in the market, or can be prepared by pre-synthesis.

The starting material needs to undergo a cyclopropylation reaction. This reaction mostly uses cyclopropyl halide as a cyclopropyl donor and is carried out under the catalysis of bases. The base can be an inorganic base such as potassium carbonate and sodium carbonate, or a strong base such as sodium hydride. React in a suitable organic solvent, such as N, N-dimethylformamide (DMF), dichloromethane, etc., and stir the reaction at a certain temperature to successfully integrate the cyclopropyl group into a specific position of the quinoline derivative.

After that, the steps of constructing the structure of [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] are carried out. Usually starting from the corresponding pyrrolido-pyridine precursors, it is achieved through a multi-step reaction. First, the key functional groups are protected with suitable protecting groups to prevent unnecessary side reactions in the reaction. Then, the target pyrrolido-pyridine structure is constructed through a series of reactions such as reduction and cyclization. Metal hydrides such as sodium borohydride and lithium aluminum hydride are commonly used in the reduction reaction. The cyclization reaction requires the selection of suitable catalysts and reaction media according to the specific reaction conditions.

Furthermore, the constructed [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridine-6-yl] structure is introduced into cyclopropylated quinoline derivatives. This step may involve reactions such as nucleophilic substitution and condensation. The reaction conditions need to be precisely regulated, such as temperature, reaction time, and ratio of reactants, to ensure that the reaction proceeds in the desired direction and obtain a high-purity target product.

During the synthesis process, the reaction products need to be separated and purified at each step. Common methods include column chromatography, recrystallization, etc. The column chromatography method can effectively separate the product and the impurity according to the polarity difference; the recrystallization method can achieve the purpose of purification by the different solubility of the product and the impurity in the solvent at different temperatures.

Finally, through multi-step reaction, separation and purification, 1-cyclopropyl-6-fluoro-8-methoxy-7 - [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid can be obtained. However, the road to synthesis requires repeated testing and optimization of conditions to achieve satisfactory yield and purity.

1-cyclopropyl-6-fluoro-8-methoxy-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-1, 4-dihydroquinoline-3-carboxylic acid What are the related drugs or products?

1 - cyclopropyl - 6 - fluoro - 8 - methoxy - 7 - [ (4aS, 7aS) - octahydro - 6H - pyrrolo [3,4 - b] pyridin - 6 - yl] - 4 - oxo - 1,4 - dihydroquinoline - 3 - carboxylic acid is ciprofloxacin, which is a quinolone antibacterial drug.

There are many ciprofloxacin-related drugs and products. In the field of medicine, there are ciprofloxacin tablets, which can be administered orally and are often used to treat respiratory tract infections, such as pneumonia, bronchitis, etc. By inhibiting the activity of bacterial DNA rotatase, it hinders bacterial DNA replication, transcription and repair, so as to achieve bactericidal and bacteriostatic effects. There are also ciprofloxacin capsules, which are also used orally, which have good efficacy against urinary system infections, such as cystitis, urethritis and other diseases. They can effectively relieve patients' symptoms such as frequent urination, urgency, and urinary pain.

There are also many ciprofloxacin-related products for external use, such as ciprofloxacin cream, which can be applied to the skin and has a therapeutic effect on skin and soft tissue infections, such as boils and impetigo. It directly acts on the infected site and reduces inflammation. Ciprofloxacin eye drops are used for eye infections, such as conjunctivitis, keratitis, etc., which can effectively kill eye bacteria and improve eye discomfort symptoms.

In addition, ciprofloxacin is also used in the field of veterinary medicine. It is made into veterinary ciprofloxacin preparations, which can treat various bacterial infectious diseases in animals and help the healthy growth of animals in the breeding industry. With its broad-spectrum antibacterial properties, ciprofloxacin plays an important role in human medicine and veterinary clinics, and plays a key role in anti-infection treatment.