1-Cyclopropyl-6-fluoro-8-hydroxy-1, 4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-3-quinolinecarboxylic acid hydrochloride

This is the name of 1-cyclopropyl-6-fluoro-8-hydroxy-1,4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolio [3,4-b] pyridine-6-yl] -4-oxo-3-quinoline carboxylic acid hydrochloride. To clarify its chemical structure, follow the method of organic chemical structure analysis.

This compound belongs to quinoline carboxylic acid derivatives. The quinoline ring is its core structure, with a carboxyl group at the 3rd position, an oxo group at the 4th position, a cyclopropyl group at the 1st position, a fluorine atom at the 6th position, and a hydroxyl group at the 8th position. Particularly critical, the 7th position is connected with a special side chain, namely (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl. This side chain exists in a specific stereo configuration (4aS, 7aS), consists of octahydro-pyrrolido-pyridine, and is connected to the quinoline ring at the 7th position. The hydrochloride salt indicates that the compound forms a salt of hydrochloric acid, and chloride ions are introduced into the structure, which are combined with the main body part by ionic bonds Overall, its structure fuses a variety of functional groups and special ring systems, and its unique structure endows it with specific chemical and biological activities, which may have important research value in the fields of medicinal chemistry.

1-Cyclopropyl-6-fluoro-8-hydroxy-1, 4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-3-quinolinecarboxylic acid hydrochloride

1-Cyclopropyl-6-fluoro-8-hydroxy-1,4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] -4-oxo-3-quinoline carboxylic acid hydrochloride, which is the name of the chemical substance, its use is quite extensive.

In the field of medicine, it is often the key raw material for the development of antibacterial drugs. Due to the special chemical structure of this substance, it is endowed with unique antibacterial activity, which can effectively inhibit the growth and reproduction of many bacteria. Therefore, it is often used to create new antibacterial drugs to deal with bacterial infection-related diseases, such as respiratory tract infections, urinary tract infections, etc. When doctors use drugs, with the help of its antibacterial effect, it relieves pain and promotes recovery for patients.

In the field of chemical research, it is also an important research object. Chemists can gain insight into the laws of related chemical reactions through in-depth investigation of its chemical properties and reaction mechanism, and contribute to the development of organic synthetic chemistry. Based on its structure, novel synthetic paths and methods can be explored to improve the efficiency and accuracy of organic synthesis, laying the foundation for the creation of more organic compounds with specific functions.

Furthermore, this substance is also of great value in the study of biological activity. By studying its interaction with various targets in organisms, researchers can reveal its mechanism of action in organisms and help the development of new drugs. Exploring its potential medicinal value may lead to the discovery of new uses in the treatment of other diseases, opening up new paths for medical development.

1-Cyclopropyl-6-fluoro-8-hydroxy-1, 4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-3-quinolinecarboxylic acid hydrochloride

1-Cyclopropyl-6-fluoro-8-hydroxy-1,4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] -4-oxo-3-quinoline carboxylic acid hydrochloride, this is an important organic compound, and its preparation method is also quite critical.

In the past, this compound was prepared with specific quinoline compounds as the starting material. In the first step, in a suitable reaction vessel, put in a quinoline substrate containing a specific substituent, add an appropriate amount of organic solvent, such as dichloromethane, N, N-dimethylformamide, etc., stir well to create a suitable reaction environment.

Then, add cyclopropylation reagents, such as cyclopropyl halide, and add alkali substances, such as potassium carbonate, sodium carbonate, etc., to promote the smooth integration of cyclopropyl into the quinoline parent structure to generate an intermediate containing cyclopropyl. This step requires precise control of the reaction temperature and time. Generally, the temperature is maintained between 0 ° C and 50 ° C, and the reaction time is about several hours to ten hours, depending on the actual reaction process. < Br >
After obtaining a cyclopropyl-containing intermediate, the fluorination reaction is carried out. Introduce a fluorine source, such as the fluorination reagent Selectfluor, etc. Under specific reaction conditions, the fluorine atom replaces the hydrogen atom at a specific position on the quinoline ring to form a fluorine-containing intermediate. This reaction condition also needs to be carefully regulated, and the temperature is mostly controlled at room temperature to 80 ° C for several hours.

Subsequently, through a series of reactions, such as hydroxylation reaction, using a suitable hydroxylation reagent, under suitable conditions, the hydroxyl group is introduced at a specific position in the quinoline ring. Then, by constructing the structure of pyridine-pyrrole, using reagents containing the corresponding structure, under appropriate reaction conditions, the construction of the 7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] part was achieved.

Finally, under suitable conditions, the obtained product is reacted with hydrochloric acid to form 1-cyclopropyl-6-fluoro-8-hydroxy-1,4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] -4-oxo-3-quinoline carboxylic acid hydrochloride. After each step of the reaction, it needs to be separated and purified by column chromatography, recrystallization and other means to ensure the purity of the product, thereby improving the quality of the final product.

1-Cyclopropyl-6-fluoro-8-hydroxy-1, 4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-3-quinolinecarboxylic acid hydrochloride

1-Cyclopropyl-6-fluoro-8-hydroxy-1,4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] -4-oxo-3-quinoline carboxylic acid hydrochloride, this is the name of the chemical substance. Quality Standards are related to many aspects.

First, the appearance should be white to off-white crystalline powder. If the color is dull or variegated, or contains obvious visible foreign matter, it does not meet the standards. This is an intuitive judgment. If you look at jade, it is pure and flawless.

Besides the purity, the purity should not be less than 98.5%, which is a key indicator. Too many impurities will affect its pharmacological activity, just like a good horse mixed with a horse, the efficacy is greatly reduced.

Moisture content is also quite important and should be controlled below 0.5%. Excessive moisture can easily cause deliquescence of the product, affecting stability and quality, just like water seepage on a wooden boat and blocked navigation.

In terms of residual solvents, organic solvents such as methanol and ethanol must meet the specified limits. If these solvents remain in excess of the standard, it will bring potential safety hazards, just like a fire hidden in the house, dangerous lurking.

The incandescent residue should not exceed 0.1%. This is the consideration of inorganic impurities to ensure the purity of the product. It is like panning for gold to remove sand, leaving real gold.

The content of heavy metals needs to be strictly controlled, and the total amount of heavy metals such as lead and mercury should not exceed 10 parts per million. Heavy metals exceeding the standard are extremely harmful, just like poison mixed with good medicine, and the consequences are unimaginable.

The above Quality Standards are to ensure the quality of 1-cyclopropyl-6-fluoro-8-hydroxy-1,4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolio [3,4-b] pyridine-6-yl] -4-oxo-3-quinoline carboxylic acid hydrochloride, so that it can play a safe and effective role in the field of medicine.

1-Cyclopropyl-6-fluoro-8-hydroxy-1, 4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-3-quinolinecarboxylic acid hydrochloride

1-Cyclopropyl-6-fluoro-8-hydroxy-1,4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] -4-oxo-3-quinoline carboxylic acid hydrochloride, this is a chemical substance that may have important applications in the field of medicine. Looking at its market prospects, it is just like the rise and fall of ancient business roads, which are also influenced by many factors.

From the demand side, if this chemical is a key intermediate for drugs, its demand may rise as the clinical application of the corresponding drug expands and the market demand for drugs for the treatment of related diseases increases. Such as the ancient business road, due to the growing demand for specialty products from a certain party, the business industry is also busy. If the corresponding drug is used to treat common and high-incidence diseases, such as some chronic inflammatory or infectious diseases, the demand for the chemical will continue to rise like a rising tide.

However, the supply side should not be underestimated. The complexity of its synthesis process is like a bumpy mountain road. If the synthesis steps are cumbersome and the conditions are harsh, it will be difficult and dangerous on the way, limiting the increase in output. The stability of the supply of raw materials is also the key. Just like the ancient trade routes relied on stable supply, if raw materials are scarce or the supply channels are unstable, it will directly impact the market supply and cause price fluctuations.

The level of competition is like the dispute between merchants and gangs in ancient times. If similar or alternative chemicals emerge in the market, it is just like the rise of new merchants and the sharing of market share. The market prospect of this chemical may be clouded. However, if it has unique advantages, such as a unique chemical structure that gives drugs better efficacy or safety, it can also be like a powerful merchant gang that can gain a firm foothold with unique products and open up a broad market.

Regulations and policies on the market are like ancient decrees on the impact of commerce. Although strict drug regulatory policies ensure quality and safety, they may also increase entry barriers and production costs such as strict decrees, affecting the progress of marketing activities. However, in the long run, compliance with production and operation can also create a healthy market environment and facilitate its steady development.

Overall, the market prospects for 1-cyclopropyl-6-fluoro-8-hydroxy-1,4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrole [3,4-b] pyridine-6-yl] -4-oxo-3-quinolinocarboxylic acid hydrochloride, opportunities and challenges coexist. All factors need to be carefully considered in order to be like a wise man in business and seize the opportunity.