1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid

This is the name of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] -4-oxo-3-quinoline carboxylic acid. According to this, its chemical structure should be analyzed by chemical methods.
Looking at its name, "quinoline carboxylic acid", it can be seen that this is a derivative of quinoline, which has a carboxyl group attached to the 3-position of the quinoline parent nucleus. " 1-Cyclopropyl ", that is, the 1-position of the quinoline parent nucleus is connected to a cyclopropyl group;" 6,8-difluoro ", each connected to a fluorine atom at Table 6 and 8;" 1,4-dihydro ", showing the double bond hydrogenation of the 1,4-position;" 4-oxo ", referring to the 4-position as a carbonyl group; and" 7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] ", is connected to a specific nitrogen-containing heterocyclic ring at the 7-position, which is composed of pyrrolido Pyridine is composed of octahydro and has a configuration of (4aS, 7aS). Therefore, the chemical structure of this compound is composed of quinoline as the parent nucleus, which is connected with cyclopropyl, fluorine atom, carbonyl, carboxyl and specific nitrogen-containing heterocycles at specific positions.

1 - cyclopropyl - 6,8 - difluoro - 1,4 - dihydro - 7 - [ (4aS, 7aS) - octahydro - 6H - pyrrolo [3,4 - b] pyridin - 6 - yl] - 4 - oxo - 3 - quinolinecarboxylic acid is ciprofloxacin, which is the leader of quinolone antimicrobial drugs. Its main uses are extensive and its efficacy is significant. Details are as follows:
First, ciprofloxacin is a mainstay in the prevention and treatment of urinary and reproductive system infections. Common urinary system infections such as pyelonephritis and cystitis are mostly caused by bacteria such as Escherichia coli. Ciprofloxacin can effectively relieve discomfort symptoms such as frequent urination, urgency, and urinary pain, and help patients return to health. For complex urinary tract infections, it can also play a key therapeutic role. In terms of reproductive system infections, whether it is prostatitis or urethritis caused by Neisseria gonorrhoeae, ciprofloxacin has a good therapeutic effect, which can effectively reduce inflammation and curb the spread of bacteria.
Second, in the field of intestinal infections, ciprofloxacin is also indispensable. For dysentery caused by Shigella and enteritis caused by Escherichia coli, ciprofloxacin can accurately combat bacteria and relieve symptoms such as diarrhea, abdominal pain, and fever. When dealing with cholera caused by Vibrio cholerae, it can cooperate with other treatment methods to help patients recover as soon as possible, which is of great significance in the field of public health.
Third, ciprofloxacin also has a place in the prevention and treatment of respiratory infections. Although the susceptibility to Streptococcus pneumoniae has changed, ciprofloxacin can still play a certain role in bronchitis, pneumonia, etc. caused by some gram-negative bacteria, helping to control infections, improve patients' respiratory conditions, and reduce symptoms such as cough, expectoration, and fever.
Fourth, in terms of skin and soft tissue infections, when Staphylococcus aureus and other bacteria invade the skin, causing furus, carbuncle, cellulitis, etc., ciprofloxacin can inhibit the growth of bacteria, promote inflammation, help wounds heal, and protect skin health.

1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] -4-oxo-3-quinolinocarboxylic acid, a key compound in the field of chemistry, is often used in the synthesis of medicine, and the preparation of many antibacterial drugs is an important intermediate.
Its synthesis method should first clarify the starting material of the reaction. An appropriate quinoline derivative can be selected as the starting substrate. The structure of this substrate needs to be in line with the quinoline core structure of the target product in order to lay the foundation for the subsequent reaction.
In the initial stage of the reaction, fluorination is performed at a specific position of the quinoline derivative to introduce 6,8-difluoro groups. This step requires careful selection of fluorinated reagents, such as Selectfluor, and strict control of reaction conditions, such as temperature and solvent. Due to the active characteristics of fluorine atoms, improper control of conditions can easily lead to side reactions, which affect the purity and yield of the product.
Then, cyclopropyl is introduced. Generally speaking, it can be achieved by nucleophilic substitution reaction. A nucleophile containing cyclopropyl is selected, and under the catalysis of a suitable base, it undergoes a substitution reaction with a specific position of the quinoline derivative to construct the cyclopropyl structure. Factors such as the strength and dosage of the base, the reaction time, etc. all have a profound impact on the reaction process.
Furthermore, the structure of [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] is constructed. This process may involve multi-step reactions, such as first forming a pyridine ring through a condensation reaction, and then reacting with hydrogenation and reduction to convert the pyridine into an octahydro-pyridine structure, and ensure that its stereochemical configuration is (4aS, 7aS). During this period, a chiral catalyst or chiral auxiliary agent should be used to guide the reaction to form a specific configuration product.
Finally, the reaction product is purified. Commonly used purification methods include column chromatography and recrystallization. Column chromatography is based on the difference in the partition coefficient between the product and the impurity in the stationary phase and the mobile phase to achieve separation; recrystallization uses the different solubility of the product and the impurity in a specific solvent with temperature to achieve the purpose of purification. Through this series of steps, high purity 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] -4-oxo-3-quinoline carboxylic acid can be obtained.

This is 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrole [3,4-b] pyridine-6-yl] -4-oxo-3-quinolinocarboxylic acid, which belongs to the quinolone class of antibacterial drugs. Its pharmacological properties are as follows:
- ** Broad antibacterial spectrum **: It has strong antibacterial activity against Gram-positive and negative bacteria. Common negative bacteria such as Escherichia coli and Klebsiella pneumoniae, as well as positive bacteria such as Staphylococcus aureus, are difficult to hide. This drug can inhibit bacterial DNA rotatase and topoisomerase IV, hinder bacterial DNA replication, transcription and repair, and cause bacterial death.
- ** Excellent permeability **: It can easily penetrate the bacterial cell membrane, reach a high concentration in the bacterial body, and give full play to the antibacterial effect. It can also be widely distributed in human tissues and body fluids, such as lungs, urinary system, intestines and other parts, which can reach effective therapeutic concentrations, so it has a good effect on multi-site infections.
- ** Long-lasting effect **: It has a long post-antibiotic effect. Even if the drug concentration is reduced to the minimum inhibitory concentration, the inhibitory effect on bacterial growth can still last for a long time. This allows the frequency of administration to be reduced and patient compliance to be improved.
- ** Drug resistance is gradually emerging **: With the wide application of this drug, the problem of bacterial drug resistance is also becoming more and more serious. Some bacteria develop drug resistance by changing the target of drug action, enhancing the active efflux system or producing inactivated enzymes. It is necessary to choose reasonably in clinical application to avoid abuse and delay the development of drug resistance.

1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] -4-oxo-3-quinoline carboxylic acid, which is the name of the chemical substance, or often called ciprofloxacin-related derivatives. When it comes to the uncommon adverse reactions of this substance, according to the ancient law, various pharmacological records and past medical records should be carefully studied.
When many physicians investigated drugs in the past, although there was no exact correspondence to the newly released chemical compounds, according to the characteristics and principles of action of the drugs, the efficacy of traditional herbs can be compared to infer their adverse reactions. As far as this substance is concerned, from its chemical structure and antibacterial mechanism of action, it can be inferred that it may have the following uncommon adverse reactions.
First, it may have a potential impact on the nervous system of the body. As traditional medical books say, some drugs with special taste are easy to disturb the mind and mind. Although this chemical is not a traditional herbal medicine, it acts on the metabolism of human cells, or causes disorders of the nervous system. Occasionally, hallucinations and mental abnormalities can be seen. It is like evil energy disturbing the mind, and the mind is abnormal.
Second, there may be hidden worries about the bones and joints. Looking at the traditional way of health, bones are dominated by the kidneys, the kidneys store essence, the essence produces marrow, and the marrow nourishes the bones. This chemical participates in complex biochemical reactions in the body, or affects the normal nourishment of the bone marrow. Occasionally, it can cause abnormal bone development in children and adolescents, or joint pain and stiffness in adults. It is like the muscles and bones lose their nourishment, and the flexion and extension are unfavorable.
Third, it may also affect the blood system. Blood flows all over the body and nourishes the organs. This substance may interfere with the normal generation and metabolism of cells in the blood. Occasionally, thrombocytopenia and leukocytosis are seen, just like the source of qi and blood biochemistry is blocked, and qi and blood are deficient.
Fourth, there may be a special reaction to the digestive system. The spleen and stomach are the foundation of acquired nature, the source of qi and blood biochemistry, and the main transportation and transformation of water and valleys. This chemical enters the body and transports through the spleen and stomach, occasionally causing nausea, vomiting, abdominal pain, diarrhea and other diseases. It is like the spleen and stomach transporting and losing the division, and the water and valleys do not melt.
Although the above are uncommon adverse reactions speculated by analogy, when it is used in clinical practice, it should be carefully observed and the reaction of patients after medication should not be ignored.