1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester

Ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinocarboxylate is a crucial compound in the field of organic synthesis. It has a wide range of uses, first in the field of medicinal chemistry, and is a key intermediate for the synthesis of many quinolone antibacterial drugs.
Quinolones can inhibit bacterial DNA gyrase or topoisomerase IV, impede bacterial DNA replication, transcription and repair, and exhibit excellent antibacterial activity. The unique structure of this compound gives it a unique advantage in the construction of quinolone parent nuclei. It can be chemically modified to introduce different substituents to optimize the antibacterial spectrum, enhance the antibacterial efficacy and improve the pharmacokinetic properties.
In the field of pesticides, it has also emerged. It can be used as a lead compound to develop new pesticides with antibacterial, insecticidal or herbicidal activities. Due to its specific biological active structural units, after rational design and modification, it is expected to obtain high-efficiency, low-toxicity and environmentally friendly pesticide varieties, which will contribute to agricultural pest control. In organic synthetic chemistry, this compound can participate in a variety of organic reactions, such as hydrolysis, esterification, substitution, etc., because it contains multiple reactive functional groups, such as ester groups, carboxyl groups, etc., providing an effective way to construct complex organic molecules and assisting in the synthesis of organic materials or fine chemicals with special structures and functions.

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid ethyl ester, this is an organic compound. Its chemical properties are unique and of great research value.
From the structural point of view, the compound contains cyclopropyl, which has a special tension, which makes its reactivity different from conventional alkyl groups. This tension can make cyclopropyl open the ring under specific conditions and participate in various chemical reactions, such as nucleophilic substitution, electrophilic addition, etc., endowing the compound with various reaction paths.
The introduction of 6,7-difluorine atoms significantly affects the distribution of its electron cloud. Fluorine atoms have high electronegativity and strong electron-absorbing effect, which can bias the molecular electron cloud towards fluorine atoms, change the charge density of surrounding atoms, and then affect the polarity and chemical reactivity of compounds. This may not only enhance its interaction with specific receptors, but also have potential applications in the field of medicinal chemistry; in organic synthesis, it will also affect the selectivity of the reaction check point and the reaction rate.
8-methoxy group as the power supply can increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution, which determines the activity and selectivity of the compound in reactions such as aromatic electrophilic substitution.
The structural part of 4-oxo-3-quinoline carboxylic acid ethyl ester in the molecule gives it a variety of chemical properties. Carbonyl is polar and can participate in nucleophilic addition reactions, such as reacting with reagents containing active hydrogen to form new compounds. The quinoline ring system has aromatic and conjugated systems, which not only make the compound have certain stability, but also affect its spectral properties and electron transfer ability.
This compound may have certain solubility in organic solvents, and the specific solubility varies depending on the properties of the solvent. In the fields of chemical synthesis, drug development, etc., the understanding of its solubility is helpful to select suitable reaction solvents and separation and purification methods.
In a chemical reaction, due to its structural complexity, it interacts with various groups, and the reaction conditions need to be precisely controlled. Different reaction types, such as oxidation, reduction, substitution, etc., need to match suitable reagents and reaction temperature, time and other parameters to obtain ideal products and yields.
In summary, 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinocarboxylate has rich chemical properties, and the synergistic effect of various groups lays the foundation for its application in organic synthesis, pharmaceutical chemistry and other fields.

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid ethyl ester, this is an organic compound, and its preparation process is as follows:
Initially, with a specific starting material, after carefully selected reaction paths, start the synthesis journey. First, the quinoline compound with the corresponding structure is placed in a reactor. In this container, many reaction conditions need to be precisely controlled, such as temperature, pressure, and the ratio of reactants. It is all about success or failure.
Dissolve the starting material with a suitable solvent to make it easier for molecules to interact. Then, in a specific order, a cyclopropylation reagent is added. This reagent is cleverly combined with a quinoline compound to successfully introduce cyclopropyl in its structure. This step of the reaction needs to be carefully monitored to ensure that the cyclopropyl is accurately connected to the target position.
Then, a fluorine substitution reaction is carried out to introduce fluorine atoms into the system, which is a key step to improve the specific properties of the compound. The introduction of fluorine atoms gives the product unique chemical activity and physical properties. Under strictly controlled reaction conditions, the fluorine substitution reagent is fully reacted with the intermediate, and the fluorine-containing intermediate product is obtained through separation and purification.
Next, the methoxylation step is carried out, and the methoxylation reagent is used to connect the methoxyl group to a specific position. This operation also requires precise regulation of the reaction parameters to ensure the precise substitution of the methoxyl group.
As for the formation of the ethyl ester structure, it is in the subsequent steps that a suitable esterification reagent is used to react with the aforementioned intermediate, and through the esterification reaction, the ethyl ester group is successfully constructed at the end of the molecule.
After each step of the reaction is completed, it is necessary to use means such as column chromatography and recrystallization to separate and purify to remove impurities and obtain high-purity products. After multi-step reaction and fine processing, 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid ethyl ester was finally obtained. This preparation process is closely related to each step, and a slight error in any link may affect the purity and yield of the product, which requires careful operation and strict control by the synthesizer.

I don't know the price range of 1 - Cyclopropyl - 6,7 - difluoro - 1,4 - dihydro - 8 - methoxy - 4 - oxo - 3 - quinolinecarboxylic acid ethyl ester in the market. However, if you want to know its price, you can go to the trading house of various chemical reagents and the market of chemical raw materials. Or on the platform of online chemical product trading, check the price quoted by each merchant in detail, and then you can know the approximate price range. The price of this compound may vary depending on the quality, purity, supply channel, and market supply and demand. If you want to get an accurate price, you need to go to the relevant market in person, consult the merchants, and compare their quotations before you can get it.

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid ethyl ester related Quality Standards are as follows:
First, the appearance should be presented as a white to light yellow crystalline powder, uniform color, no visible foreign matter. This feature is like the quality of jade, the appearance of pure can be preliminarily determined its quality. The state of the powder, the degree of fineness is also related to subsequent use, it is necessary to ensure that the particles are uniform, neither too coarse to affect the dissolution and other properties, nor too fine to cause inconvenience such as flying.
Second, the melting point is usually within a specific temperature range, such as [specific temperature range]. The melting point is like the "individual temperature" of a substance, and accurately controlling this temperature range is like mastering the key to opening the door to its purity and characteristics. If the melting point deviates from the normal range, high or low, it indicates that there may be impurity interference in the substance, just like music is out of tune, indicating quality deviation.
Third, purity detection is very critical. Using high-performance liquid chromatography and other precision means to determine, its purity should generally not be lower than [specific purity value]. Purity to the substance is like the fullness of the fruit. The higher the purity, the better the effect in various application scenarios. The presence of impurities may not only affect its own performance, but also cause adverse reactions or reduce the overall efficiency when reacting or applying with other substances.
Fourth, the residual solvents need to follow strict restrictions. Like common organic solvents, such as methanol, ethanol, acetone, etc., the residual amount must meet the established standards. If the residual solvent exceeds the standard, it will not only affect the stability of the substance, but also may bring safety hazards in subsequent use. It is like a "cancer" hidden in the dark. Although it is difficult to detect for a while, it may cause serious consequences at a critical time.
Fifth, the moisture content cannot be ignored. Generally, it should be controlled below [specific moisture value]. Moisture is like an "invisible factor" in a substance. Excessive moisture may cause reactions such as hydrolysis, damage the structure of the substance, and affect its quality and performance. Therefore, strict restrictions are required to ensure that the substance is at an appropriate degree of dryness.