1 Cyclopropyl 6 7 8 Trifluoro 1 4 Dihydro 4 Oxo 3 Quinoline Carboxylic Acid
quinoline thiophene imidazole thiazole

1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid

Taiy Chemical

    Specifications

    HS Code

    849661

    Chemical Name 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
    Molecular Formula C13H9F3N2O3
    Molecular Weight 284.217 g/mol
    Appearance Solid (usually a powder)
    Physical State Solid at room temperature
    Melting Point Approximately 250 - 260 °C (decomposes)
    Solubility Poorly soluble in water, soluble in organic solvents like DMSO
    Pka Around 6.0 (carboxylic acid group)
    Uv Absorption Absorbs in the ultraviolet region, characteristic peaks can be used for identification
    Structural Features Contains a cyclopropyl group, trifluorinated benzene ring, and a quinoline - carboxylic acid moiety

    As an accredited 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing
    Storage
    Shipping
    Free Quote

    Competitive 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615365036030 or mail to info@alchemist-chem.com.

    We will respond to you as soon as possible.

    Tel: +8615365036030

    Email: info@alchemist-chem.com

    General Information
    Where to Buy 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid in China?
    As a trusted 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the chemical structure of 1-cyclopropyl-6,7,8-trifluoro-1, 4-dihydro-4-oxo-3-quinoline carboxylic acid
    1 - cyclopropyl - 6,7,8 - trifluoro - 1,4 - dihydro - 4 - oxo - 3 - quinoline carboxylic acid, that is, ciprofloxacin carboxylic acid, its chemical structure is as follows:
    This compound belongs to quinolones and has a quinoline parent nuclear structure. The quinoline ring is fused with a hexabenzene ring and a five-membered pyridine ring. There is a cyclopropyl group connected to the first position, and the cyclopropyl group consists of three carbon atoms to form a triangular ring structure, which is connected to the quinoline ring by a single bond. The fluorine atoms are connected to the 6th, 7th, and 8th positions, respectively, and the fluorine atoms are highly electronegative. The 4-position is a carbonyl group (C = O), which is connected by a double bond, so that the 4-position carbon atoms reach a stable electronic structure. The 3-position has a carboxyl group (-COOH), which is acidic and can undergo acid-base reactions. This structure endows it with unique chemical and biological activities and plays an important role in the field of antibacterial drugs. Its structural characteristics can act on targets such as bacterial DNA spin enzymes, interfere with bacterial DNA replication, transcription and other processes, and thus exert antibacterial effects.
    What are the main uses of 1-cyclopropyl-6,7,8-trifluoro-1, 4-dihydro-4-oxo-3-quinoline carboxylic acid
    1 - cyclopropyl - 6,7,8 - trifluoro - 1,4 - dihydro - 4 - oxo - 3 - quinoline carboxylic acid, often called ciprofloxacin carboxylic acid in Chinese, is a key intermediate in the synthesis of quinolone antibacterial drugs such as ciprofloxacin. Its main uses are as follows:
    - ** Antibacterial drug synthesis **: Based on this, different groups can be introduced to obtain quinolone antibacterial drugs with unique antibacterial activity and pharmacokinetic properties. Ciprofloxacin is an important product and has strong antibacterial power against Gram-positive and negative bacteria, such as Escherichia coli, Staphylococcus aureus, etc. Clinically used for the treatment of respiratory tract, urogenital tract, gastrointestinal tract and other local infections, such as pneumonia, urethritis, enteritis, etc. Because of its broad antibacterial spectrum and strong activity, it can effectively deal with infections caused by a variety of bacteria and provide strong protection for patient recovery.
    - ** Pharmaceutical R & D Basis **: In the field of medical research, it has laid the foundation for the research and development of new quinolones. By modifying and modifying its structure, researchers explore the relationship between structure and activity, and hope to develop new varieties with higher antibacterial activity, better safety, and low drug resistance. Such as adjusting the position, type, and quantity of substituents, changing the affinity and pharmacokinetic properties of drugs and bacterial targets to meet diverse clinical needs. < Br > - ** Quality Research and Standard Formulation **: Because it is a key intermediate, its quality research, such as purity, impurity type and content, can ensure the quality of subsequent synthetic drugs. The formulation of strict Quality Standards can ensure the stability of drug efficacy and safety. The production process is strictly controlled according to the standards, which can avoid the poor efficacy and adverse reactions of the finished drug due to the quality problems of the intermediate.
    What is the synthesis method of 1-cyclopropyl-6,7,8-trifluoro-1, 4-dihydro-4-oxo-3-quinoline carboxylic acid
    1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid, which is the key intermediate of quinolone antibacterial drugs. Its synthesis method often follows a multi-step reaction process.
    The initial step is to form a quinoline ring system through cyclization with suitable starting materials. Or select fluorobenzene-containing compounds and suitable nitrogen-containing heterocyclic precursors, and under suitable reaction conditions, such as alkali catalysis and specific temperature and solvent environment, make the two condensation reactions occur to initially generate quinoline derivatives. The key to this step is to precisely adjust the reaction conditions to promote the smooth progress of the reaction in the expected direction of cyclization and improve the yield and purity of the target product.
    Subsequently, for the obtained quinoline derivatives, cyclopropyl is introduced. This purpose can be achieved through nucleophilic substitution reaction, where the reagent with cyclopropyl is reacted with the quinoline derivative under specific conditions. In this process, it is extremely important to control the activity of the reagent, the polarity of the reaction solvent, and the reaction temperature. If the conditions are improper, side reactions may occur, which will affect the quality of the product.
    In the synthesis process, the separation and purification of the reaction products at each step is also crucial. Methods such as column chromatography and recrystallization are often used to remove impurities and obtain a pure target product. Each step of the reaction needs to be carefully monitored and controlled. Thin-layer chromatography (TLC), nuclear magnetic resonance (NMR) and other analytical methods are used to confirm the progress of the reaction and the structure of the product, and to ensure the smooth synthesis route. In this way, after carefully designing and manipulating the reaction in multiple steps, 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid can be successfully prepared.
    What are the physical and chemical properties of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
    1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid, this is an organic compound. Its physical and chemical properties are unique, let me tell you in detail.
    Looking at its properties, under normal temperature and pressure, it is mostly solid, crystalline, white or near-white, and mostly powdery, which is convenient for storage and operation. Its melting point is relatively high, which is due to the intermolecular force. In the molecular structure, cyclopropyl, fluorine atoms and quinoline carboxylic acid structural units interact, so that the molecules are tightly packed, and high energy is required to cause them to melt. < Br >
    When it comes to solubility, the solubility in water is quite low. Due to the limited polarity of the genome molecule, although the carboxyl group can interact with water to a certain extent, the hydrophobic groups such as cyclopropyl group and fluorine atom have a greater impact. However, in some organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF) and other polar organic solvents, it has good solubility. This property is of great significance in organic synthesis and drug development, and suitable solvents can be selected for reactions or preparations.
    Its chemical stability is also worth mentioning. The structure of the quinoline ring gives it a certain conjugate stability, but the carboxyl group is acidic, and it is easy to react in an alkaline environment to form corresponding carboxylate. Although cyclopropyl is relatively stable, it may also open the ring under certain conditions, such as the action of strong nucleophiles. At the same time, fluorine atoms have high electronegativity, which reduces the electron cloud density of carbon atoms connected to them, affects the activity of surrounding chemical bonds, and can change the reaction path and rate in some reactions.
    1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinocarboxylic acids The physicochemical properties of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acids are determined by their unique molecular structures and are widely used in many fields. The study of their properties is of great significance to the development of related fields.
    1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid market prospects
    1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid, Chinese name is 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxyquinoline-3-carboxylic acid, which is a key intermediate in the synthesis of quinolone antibacterial drugs. Looking at its market prospects, it is like a shining star in the vast starry sky, bright and promising.
    Since the development of the field of antibacterial drugs, the pursuit of high-efficiency, broad-spectrum and low-toxicity antibacterial agents has never stopped. Quinolones have emerged in the pharmaceutical arena due to their unique antibacterial mechanism and good antibacterial activity. And this intermediate, like the cornerstone of building a solid drug building, is necessary for the synthesis of many quinolones antibacterial drugs.
    From the current medical and health landscape, infectious diseases are still frequent, and both community-acquired infections and nosocomial infections are in high demand for highly effective antibacterial drugs. The quinolones involved in this intermediate have significant antibacterial activity against Gram-positive and negative bacteria, and can play an important role in the treatment of many infections such as respiratory tract, urinary tract, and gastrointestinal tract.
    Furthermore, with the advancement of science and technology, the pharmaceutical process continues to innovate. The research on the synthesis method of this intermediate is also becoming more and more mature, the cost is gradually controllable, and the quality is more and more stable. In this way, it will pave the way for its market expansion. Many pharmaceutical companies have invested in the research and development and production of related drugs to meet the needs of the clinic and the market.
    And with the intensification of global population mobility, the pressure of infectious disease prevention and control has increased, and the strategic position of antibacterial drugs has become increasingly prominent. As a key link in the synthesis of quinolones, this intermediate is like the key to unlocking the treasure trove of antibacterial drugs. The market prospect is extremely broad, and it is expected to write a brilliant chapter in the future pharmaceutical field and contribute significantly to human health and well-being.