1 Chloro 5 Bromoisoquinoline
quinoline thiophene imidazole thiazole

1-Chloro-5-bromoisoquinoline

Taiy Chemical

    Specifications

    HS Code

    938016

    Chemical Formula C9H5BrClN
    Molar Mass 242.499 g/mol
    Appearance Solid (usually)
    Solubility In Water Low solubility
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform

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    General Information
    Where to Buy 1-Chloro-5-bromoisoquinoline in China?
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    Frequently Asked Questions

    As a leading 1-Chloro-5-bromoisoquinoline supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the chemistry of 1-Chloro-5-bromoisoquinoline?
    1-Chloro-5-bromoisoquinoline is one of the organic compounds. Its chemical properties are well-researched.
    First of all, the properties of its halogen atom. Chlorine and bromine are both halogen elements. In the structure of 1-chloro-5-bromoisoquinoline, the activity of chlorine and bromine atoms is considerable. Halogen atoms are electron-absorbing, which can reduce the electron cloud density of the isoquinoline ring and make the electron distribution on the ring different from normal. This is the key to affecting many reaction characteristics of this compound.
    As for the nucleophilic substitution reaction, due to the electron absorption of the halogen atom, the density of the adjacent and para-position electron clouds on the isoquinoline ring is relatively low, which is easy to attract the attack of nucleophilic reagents. The nucleophilic reagent can replace the halogen atom by bonding with the carbon atom connected to the halogen atom by providing an electron pair. In this process, the halogen atom leaves in the form of a halogen ion.
    It can also participate in metal-catalyzed reactions. For example, in palladium-catalyzed cross-coupling reactions, with the assistance of appropriate ligands and bases, the halogen atom of 1-chloro-5-bromoisoquinoline can be coupled with carbon-containing nucleophiles to form new carbon-carbon bonds. This is an important means to construct complex molecular structures in organic synthesis.
    In addition, the isoquinoline ring of 1-chloro-5-bromoisoquinoline is aromatic and can undergo typical aromatic reactions. For example, in an electrophilic substitution reaction, although the electron cloud density on the ring is reduced due to the electron absorption of the halogen atom, it can still react with the electrophilic reagent under appropriate conditions to replace the hydrogen atom on the ring. However, due to the localization effect of halogen atoms, the reaction check point is selected, and it is more inclined to the neighbor and para-position of halogen atoms.
    Because of the existence of different electronegative atoms in the molecule, it can form inter-molecular or intramolecular weak interactions, such as hydrogen bonds, etc., which also affect its physical properties, such as melting point, boiling point, solubility, etc. In polar solvents, the solubility may vary due to the interaction with solvent molecules. The chemical properties of 1-chloro-5-bromoisoquinoline are determined by the synergy between the halogen atom and the isoquinoline ring in its structure, which is of great significance in the fields of organic synthesis and medicinal chemistry. Many reaction properties provide opportunities for creating new compounds and expanding the path of organic synthesis.
    What are the main uses of 1-Chloro-5-bromoisoquinoline?
    1-Chloro-5-bromoisoquinoline is an important compound in the field of organic synthesis. It has a wide range of uses and plays a key role in many fields.
    In the field of medicinal chemistry, this compound is often used as a key intermediate for the synthesis of specific biologically active drug molecules. Due to its unique chemical structure, various chemical reactions can be used to construct structures that are compatible with biological targets, and then drugs can be developed to treat specific diseases. For example, studies have shown that by modifying its structure, compounds that have significant inhibitory effects on certain tumor cells can be synthesized, providing new directions for the development of anti-cancer drugs.
    In the field of materials science, 1-chloro-5-bromoisoquinoline also has important applications. It can be chemically converted to introduce it into the structure of polymer materials, thereby imparting special properties to the materials. For example, it can improve the photoelectric properties of materials and be used in the fabrication of optoelectronic devices such as organic Light Emitting Diodes (OLEDs), which improves the luminous efficiency and stability of the devices.
    In addition, in the field of organic synthesis chemistry, as an important intermediate, it can participate in many organic reactions, such as nucleophilic substitution reactions, metal-catalyzed coupling reactions, etc. With the help of these reactions, more complex organic molecular structures can be constructed, laying the foundation for the synthesis of organic compounds with special functions and structures. Chemists often use its structural characteristics to design novel synthetic routes to prepare organic materials and compounds with unique properties.
    In conclusion, 1-chloro-5-bromoisoquinoline, with its unique chemical structure, has shown important application value in many fields such as drug research and development, materials science and organic synthesis, promoting the continuous development and innovation of related fields.
    What is 1-Chloro-5-bromoisoquinoline synthesis method?
    The synthesis of 1-chloro-5-bromoisoquinoline is an important content in the field of organic synthesis. Its synthesis path can be achieved through multi-step reactions.
    The first step is often to use isoquinoline as the starting material. The structure of isoquinoline has unique aromatic ring characteristics, which lays the foundation for subsequent reactions. In the halogenation reaction of isoquinoline, chlorine and bromine atoms can be introduced.
    In the halogenation reaction, suitable halogenation reagents can be selected. If chlorine atoms are to be introduced, chlorine-containing halogenating agents such as sulfoxide chloride can be used. The reaction conditions need to be carefully regulated, and temperature, reaction time and the proportion of reactants are all key factors. Too high or too low temperature may affect the reaction process and product selectivity.
    When introducing bromine atoms, bromine or other brominating reagents can be selected. Likewise, careful control of reaction conditions is required to ensure that bromine atoms are precisely introduced into the target position, that is, the 5-position.
    During the synthesis process, protection and deprotection steps may also be involved. Because other activity check points on the isoquinoline ring may be affected during halogenation, specific groups need to be protected. After the target halogenation reaction is completed, deprotection is performed to obtain a pure 1-chloro-5-bromoisoquinoline product.
    In addition, the choice of reaction solvent is also important. A suitable solvent can promote the dissolution of the reactants, which is conducive to the mass and heat transfer of the reaction, thereby improving the reaction efficiency and product yield.
    In short, the synthesis of 1-chloro-5-bromoisoquinoline requires comprehensive consideration of many factors such as reaction steps, reagent selection, condition control and solvent, and careful design and operation to obtain the target product.
    1-Chloro-5-bromoisoquinoline need to pay attention to when storing
    1-Chloro-5-bromoisoquinoline is an organic compound. When storing, many aspects need to be paid attention to.
    First, when protected from light. This compound may be sensitive to light, under light, or cause luminescent chemical reactions, causing it to decompose or deteriorate. Therefore, it should be stored in a dark container such as a brown bottle, and stored in a dark place.
    Second, the temperature should be controlled. Generally speaking, it should be placed in a cool environment to prevent its volatilization from intensifying due to high temperature, the rate of chemical reactions is accelerated, and even adverse consequences such as decomposition. The ideal storage temperature or refrigeration environment at 2-8 ° C depends on its physicochemical properties.
    Third, humidity must be paid attention to. In a high humidity environment, some compounds may absorb moisture, which in turn affects their purity and stability. Therefore, it should be stored in a dry place, and a desiccant can be placed in a storage container to maintain a dry environment.
    Fourth, the storage place should be well ventilated. 1-chloro-5-bromoisoquinoline may be volatile and irritating. Good ventilation can avoid its local accumulation, reduce safety risks, and is also beneficial to the health of workers.
    Fifth, this compound should be stored separately from oxidants, reducing agents, acids, alkalis and other substances. Due to its chemical properties, contact with these substances, or cause severe chemical reactions, such as combustion, explosion and other serious consequences.
    Finally, the storage container must be well sealed. On the one hand, it can prevent its volatilization from escaping, polluting the environment and causing waste; on the other hand, it can avoid the intrusion of impurities such as outside air and moisture, which will affect its quality and stability.
    When storing 1-chloro-5-bromoisoquinoline, attention should be paid to light, temperature, humidity, ventilation, isolation from other substances and container sealing, so as to ensure its stability, extend the storage period and ensure the safety of use.
    What is the market price of 1-Chloro-5-bromoisoquinoline?
    For 1-chloro-5-bromoisoquinoline, the market price is straight, and it is difficult to determine. This is a fine chemical, and its price often changes due to multiple reasons.
    The method of preparation is quite complex, and the price of raw materials and the art of preparation are the main factors. If the raw materials are easy and affordable, and the preparation art is good and the cost is saved, the price may be slightly lower. However, if the raw materials are rare and expensive, and the preparation process is complicated, special tools and agents are required, the price will be high.
    Changes in market conditions are also important. If there are many people who want it, and there are few people who supply it, the price will increase; on the contrary, if the supply exceeds the demand, the price may decrease. And the price varies from place to place, due to the difference in transportation fees, taxes, etc.
    Also, the difference in quality is also related to the price. High quality, the price must be higher than the usual. Generally speaking, the price per gram, or from tens to hundreds of yuan, is difficult to determine. To know the exact price, you should consult the chemical supplier, depending on the current market conditions and quality.