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What is the chemical structure of 1-azabicyclo [2.2.2] oct-3-yl (1S) -1-phenyl-3, 4-dihydroisoquinoline-2 (1H) -carboxylate butanedioate (1:1)?
This is related to the chemical structure of 1-azabicyclo [2.2.2] octyl-3-yl (1S) -1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylate succinate (1:1). This compound has a complex structure and contains multiple special groups.
According to its name, 1-azabicyclo [2.2.2] octyl-3-yl is a unique bilicyclic structure, which is connected by a delicate ring. The nitrogen atom is embedded in the ring to determine its characteristics. ( 1S) -1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid ester moiety, with phenyl and dihydroisoquinoline ring, and carboxylic acid ester groups are connected to it, and the spatial arrangement is determined by the (1S) configuration. The two are connected to form an ester bond to build a molecular main framework.
Furthermore, succinate (1:1), that is, succinate acid and the above main body are estered in a ratio of 1:1. The succinate acid contains a dicarboxyl group, which reacts with the main body here, or makes the molecule have special chemical activity and solubility. Overall, this compound is exquisitely designed, interacting with its various groups, or endowing it with unique physical and chemical properties and biological activities, making it useful in the fields of chemistry and medicine.
What are the physical properties of 1-azabicyclo [2.2.2] oct-3-yl (1S) -1-phenyl-3, 4-dihydroisoquinoline-2 (1H) -carboxylate butanedioate (1:1)?
1-Azabicyclo [2.2.2] octyl-3-yl (1S) -1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylate succinate (1:1), this is an organic compound with unique physical properties.
Looking at its morphology, under room temperature and pressure, it is mostly in the shape of white to quasi-white crystalline powder, which is delicate and uniform, and this morphology is easy to store and use. Its melting point is in a specific range, about [X] ℃ to [X] ℃. The stability of the melting point is one of the important basis for identifying the compound. < Br >
In terms of solubility, in organic solvents, such as methanol, ethanol, dichloromethane, etc., it exhibits a certain solubility and can be well dispersed and dissolved to form a uniform solution; however, in water, the solubility is quite limited and only slightly soluble. This difference in solubility is of great significance in the separation, purification and application of compounds.
In terms of stability, under conventional environmental conditions, it is relatively stable and can be stored for a long time without significant deterioration. However, it is necessary to avoid high temperatures, open flames and strong oxidants to prevent chemical reactions from triggering and causing structural changes. When encountering strong acids and alkalis, hydrolysis reactions are prone to occur, causing molecular structure damage and loss of original characteristics.
The physical properties of this compound have a profound impact on its application in medicinal chemistry, organic synthesis and other fields. Its specific morphology, melting point, solubility and stability lay an important foundation for related research and practical applications.
What are the main uses of 1-azabicyclo [2.2.2] oct-3-yl (1S) -1-phenyl-3, 4-dihydroisoquinoline-2 (1H) -carboxylate butanedioate (1:1)?
1 - azabicyclo [2.2.2] oct - 3 - yl (1S) -1 - phenyl - 3,4 - dihydroisoquinoline - 2 (1H) -carboxylate butanedioate (1:1), this is the name of an organic compound, its main use is very critical in the field of medicine and chemistry research today.
In the field of medicine, this compound is often an important starting material or active ingredient for the development of new drugs. Its unique chemical structure gives it the potential to interact with specific targets in organisms, or to regulate certain physiological processes, and then it is expected to become an effective drug for the treatment of specific diseases. For example, by binding to specific receptors on the cell surface, it affects cell signaling pathways and plays a therapeutic role in related diseases such as neurological diseases and cardiovascular diseases.
In the field of chemical research, it can be used as a key intermediate for the synthesis of more complex organic compounds with special functions. Chemists explore new synthetic pathways and methods by performing a series of chemical modifications and reactions on it, expanding the boundaries of organic synthetic chemistry. Furthermore, in-depth study of its physical and chemical properties also helps to understand the principle of intermolecular interactions, providing experimental basis for the development of theoretical chemistry. In short, this compound occupies a pivotal position in the frontier research of medicine and chemistry, and contributes greatly to the progress of related fields.
What are the preparation methods of 1-azabicyclo [2.2.2] oct-3-yl (1S) -1-phenyl-3, 4-dihydroisoquinoline-2 (1H) -carboxylate butanedioate (1:1)?
To prepare 1 - azabicyclo [2.2.2] oct - 3 - yl (1S) -1 - phenyl - 3,4 - dihydroisoquinoline - 2 (1H) -carboxylate butanedioate (1:1), there are three methods.
First, start with (1S) -1 -phenyl-3,4 -dihydroisoquinoline-2 (1H) -carboxylic acid and 1-azabicyclo [2.2.2] octan-3 -ol, so that the two are stored in shrinkage agents, such as dicyclohexyl carbodiimide (DCC) and 4-dimethylaminopyridine (DMAP), in suitable solvents, such as dichloromethane, stirred at room temperature to form esters. Afterwards, at succinic acid, in a ratio of 1:1, the target substance is obtained. This way, the shrinkage agent has a high valence, and the by-product dicyclohexyl urea is difficult to separate. < Br >
Second, first prepare its active ester with (1S) -1 - phenyl - 3,4 - dihydroisoquinoline - 2 (1H) -carboxylic acid, such as esters with p-nitrophenol, promoted by DCC and DMAP. Then, make 1 - azabicyclo [2.2.2] octan - 3 - ol in response to it, and form esters under mild conditions. Then succinic acid is used to obtain the desired. This method has strong reactivity of active esters and high yield. However, one more step is to make active esters, and the step is to increase reproduction.
Third, use 1-azabicyclo [2.2.2] octan-3-ol to form a semiester with succinic anhydride, and then (1S) -1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid in a suitable solvent. In this way, succinic anhydride is cleverly used, or the operation is simplified, but the preparation of semiester and subsequent reaction conditions need to be fine-tuned to achieve optimum effect.
All these methods have their own advantages and disadvantages. When they are implemented, they should be selected according to the availability of materials, cost, yield, and difficulty in separation, so as to become the target compound.
1-Azabicyclo [2.2.2] oct-3-yl (1S) -1-phenyl-3, 4-dihydroisoquinoline-2 (1H) -carboxylate butanedioate (1:1) Are there any safety risks or precautions?
1-Azabicyclo [2.2.2] octyl-3-yl (1S) -1 -phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxysuccinate (1:1) This material is related to safety risks and precautions, and it needs to be carefully observed.
Although I do not know its specific properties and uses, it is common sense to infer that chemical substances may pose various risks. First, chemically synthesized substances have complex compositions or are toxic. If inhaled through the mouth and nose, in contact with the skin, or causing discomfort to the human body, it can cause skin itching, respiratory tract irritation, and can damage the organs and endanger life. Second, it may be flammable or explosive in a specific environment. In case of an open flame, hot topic, or causing a violent reaction, it will cause fire, explosion, and damage to people.
Therefore, when using this object, it is necessary to strictly abide by the procedures. Operators should use protective equipment, such as protective clothing, gloves, goggles, etc., to prevent contact. The operation room should be well ventilated to avoid gas accumulation. Storage should also be careful, choose a cool, dry and ventilated place, and avoid mixing with contraindicated substances. Dispose of it properly and do not discard it at will to prevent pollution of the environment and harm to life.
Although this thing is not known in detail, according to the chemical nature and safety requirements, none of the above things should be ignored. Those who watch this thing should always be vigilant to ensure safety.