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What is the chemical structure of (±) -4-ethyl-4,9-dihydroxy-1h-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4h, 12h) -dione
(±) - 4-ethyl-4,9-dihydroxy-1H-pyrano [3 ', 4': 6,7] indolicino [1,2-b] quinoline-3,14 (4H, 12H) -dione, this is a complex organic compound. Looking at its name, it can be inferred that its structure has a specific functional group and ring system.
"4-ethyl", which is clearly connected to the 4th carbon (-C ² H); "4,9-dihydroxy", which is known that each of the 4th and 9th carbons is connected to a hydroxyl group (-OH). "1H-pyrano [3 ', 4': 6,7] indolicino [1,2-b] quinoline", this is a fused ring structure, and the pyran ring fuses with the indolicino and quinoline ring system. The pyran ring contains an oxygen atom and is unsaturated; the indolicino and quinoline ring systems are also nitrogen-containing heterocycles with unique conjugate structures. "-3,14 (4H, 12H) -dione" indicates that it is a carbonyl group (C = O) at the 3rd and 14th positions, and the hydrogen atoms at this two positions are in the 4H and 12H states, respectively.
This compound has a complex structure, and its functional groups interact with the ring system, or it has unique chemical and physical properties. It may have important research value in the fields of organic synthesis and medicinal chemistry.
What are the main physical properties of (±) -4-ethyl-4,9-dihydroxy-1h-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4h, 12h) -dione
(±) -4-ethyl-4,9-dihydroxy-1H-pyrano [3 ', 4': 6,7] indolicino [1,2-b] quinoline-3,14 (4H, 12H) -dione, which is a rather complex organic compound. Its main physical properties are as follows:
- ** Appearance properties **: Generally speaking, this compound may be in a crystalline solid state. Due to the complex structure of this kind of compound containing polycyclic and multiple hydroxyl groups and carbonyl groups, it often interacts with Van der Waals forces by means of intermolecular hydrogen bonds, resulting in a regular crystal structure. < Br > - ** Melting point **: Due to the existence of many groups that can form hydrogen bonds in the molecule and the complex conjugate system, its melting point may be relatively high. The conjugate system enhances the stability of the molecule, while the hydrogen bond increases the intermolecular force. The synergy between the two results in a higher temperature to break the lattice energy and realize the transition from solid to liquid.
- ** Solubility **: Because of its hydrophilic hydroxyl group and hydrophobic polycyclic hydrocarbon group structure in the molecule, it may have certain solubility in polar organic solvents such as methanol, ethanol, and dimethyl sulfoxide. Hydroxyl groups can form hydrogen bonds with polar solvents, thereby increasing solubility; however, the larger hydrophobic polycyclic part will limit their solubility in water, so their solubility in water may be relatively low.
- ** Spectral properties **: In the infrared spectrum, hydroxyl groups will exhibit strong and wide absorption peaks at 3200-3600 cm fond, which is caused by the stretching vibration of hydroxyl groups; carbonyl groups will exhibit characteristic absorption peaks at 1650-1750 cm fond, which is caused by the stretching vibration of carbonyl groups. In nuclear magnetic resonance hydrogen spectroscopy, hydrogen atoms in different chemical environments will exhibit signal peaks at corresponding chemical shifts, which can be used to analyze the structure of molecules and the distribution of hydrogen atoms.
(±) -4-ethyl-4,9-dihydroxy-1h-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4h, 12h) -dione in what areas are used
(±) - 4-ethyl-4,9-dihydroxy-1H-pyrano [3 ', 4': 6,7] indano [1,2-b] quinoline-3,14 (4H, 12H) -dione, a complex organic compound, which has applications in many fields.
In the field of medicine, it shows unique potential. Or because of its specific chemical structure, it can interact with specific targets in organisms. For example, it can affect cell signaling pathways by precisely docking specific proteins or enzymes. In anti-tumor research, it may be able to inhibit tumor cell proliferation, induce tumor cell apoptosis, and provide new ideas for solving cancer problems. Or in neurological diseases, regulate the release of neurotransmitters, improve neurological function, and help the treatment of Parkinson's disease, Alzheimer's disease and other diseases.
In the field of materials science, it also has potential. With its unique structure, it gives materials novel properties. It may be used as a fluorescent material in optical sensors, with its excited light properties, to accurately detect specific substances in the environment, such as heavy metal ions, harmful gases, etc. Or it may participate in the construction of high-performance polymer materials, enhance the mechanical properties and thermal stability of materials, and expand the application of materials in high-end fields such as aerospace and automobile manufacturing.
In the field of total synthesis of natural products, the research on its synthesis is of great significance. The synthesis of this compound requires chemists to carefully design reaction routes and skillfully use various organic reactions. This not only promotes the development of organic synthesis methodologies, accumulates experience for the synthesis of other complex natural products, but also helps to deeply explore the biological activities of natural products, reveals the secrets of nature's chemistry, and lays the foundation for the subsequent development of new drugs and the creation of new materials.
What are the synthesis methods of (±) -4-ethyl-4,9-dihydroxy-1h-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4h, 12h) -dione
The synthesis of (±) -4-ethyl-4,9-dihydroxy-1H-pyrano [3 ', 4': 6,7] indolicino [1,2-b] quinoline-3,14 (4H, 12H) -dione is an important topic in the field of chemical synthesis. To obtain this compound, the following paths can be tried.
First, use natural products as starting materials. Seek natural products rich in similar structural fragments, and gradually convert them to the target product through fine chemical modification. For example, if a raw material with a pyran ring or quinoline structure is found, the required hydroxyl and ethyl functional groups can be introduced through selective oxidation, reduction, substitution and other reactions, and the indolicino ring system can be skillfully constructed. The key to this path lies in a deep understanding of the structure of natural products and precise control of the reaction conditions of each step, and strive to achieve selective transformation at specific positions in complex structures.
Second, the total synthesis strategy is adopted. Starting from simple basic raw materials, the target molecular skeleton is built through multi-step reactions. The quinoline ring can be constructed first, and suitable aniline and aldehyde compounds can be selected to form the quinoline mother nucleus through condensation reaction under acidic or basic catalysis. Subsequently, the pyran ring and the indolicino ring are introduced. When constructing the pyran ring, the condensation reaction of enol ether and aldehyde and ketone can be used to form the pyran ring structure; for the indolicino ring, it can be achieved by reactions such as nucleophilic substitution in molecules. In this process, the reaction sequence needs to be carefully designed and the interaction between functional groups needs to be considered to avoid unnecessary side reactions.
Third, the reaction is catalyzed by transition metals. Transition metal catalysts have unique advantages in constructing complex carbon-carbon bonds and carbon-heterogeneous bonds. For example, the coupling reaction catalyzed by palladium can precisely connect different structural fragments to achieve the introduction of ethyl and other groups. At the same time, the metal-catalyzed cyclization may play a key role in the construction of the ring structure, and the selectivity and yield of the cyclization reaction can be optimized by adjusting the ratio of reaction substrate and catalyst, reaction temperature, solvent and other conditions.
Synthesis of (±) -4-ethyl-4,9-dihydroxy-1H-pyrano [3 ', 4': 6,7] indolicino [1,2-b] quinoline-3,14 (4H, 12H) -dione requires comprehensive consideration of factors such as the availability of raw materials, the difficulty of reaction conditions, and the purity and yield of the target product. The appropriate synthesis path is carefully selected, and the reaction of each step is carefully optimized to achieve the ideal synthesis effect.
What is the biological activity of (±) -4-ethyl-4,9-dihydroxy-1h-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4h, 12h) -dione
(±) -4-ethyl-4,9-dihydroxy-1H-pyrano [3 ', 4': 6,7] indolicino [1,2-b] quinoline-3,14 (4H, 12H) -dione, the biological activity of this compound is related to many aspects.
It has a significant impact on the proliferation and differentiation of specific cells at the cellular level. Looking at past studies, it seems that the compound can bind to the central proteins of some key signaling pathways in cells, which is like key unlocking, precise and ingenious. In this way, it is like flipping delicate organs, affecting signal transmission, and thus changing the trajectory of cell growth.
At the level of the body as a whole, it may participate in regulating the immune response. It is like commanding a general of thousands of troops to guide the actions of immune cells. When the body faces the invasion of external pathogens, it may enhance the activity of immune cells, making it like a well-trained soldier, more efficient in identifying and destroying pathogens.
Furthermore, in the field of metabolic regulation, it also has potential effects. Or like a fine craftsman, carving metabolic pathways. It can act on some key enzymes involved in metabolism, changing their activity, and then regulating the body's absorption, transformation and utilization of nutrients.
However, the matter of biological activity is intricate, like the intertwined ancient wood. Although existing research has revealed some of its characteristics, there are still many unknowns, such as the deep forest shrouded in fog, which urgently needs to be further explored and studied by future generations to clarify all its mysteries.