[2,2'-biquinoline]-4,4'-dicarboxylic acid

"[2,2 '-biquinoline] -4,4' -dicarboxylic acid", according to its name, this is an organic compound. Its structure contains two quinoline rings connected by the 2,2 '-position, and this biquinoline structure is its core framework. At the 4,4' -position, each is connected with a carboxyl group (-COOH). This dicarboxyl group imparts a certain polarity and reactivity to the compound. The
quinoline ring itself has a conjugated system, which is planar and provides a certain rigidity and stability. The two quinoline rings are connected at the 2,2 '-position, which affects the molecular spatial configuration and electron cloud distribution. The presence of carboxyl groups enables molecules to participate in a variety of chemical reactions, such as salt formation with bases, esterification with alcohols, etc.
The structural characteristics of this compound determine that it may have unique applications in materials science, coordination chemistry and other fields. In coordination chemistry, carboxyl groups can be used to coordinate with metal ions to construct metal-organic framework materials; in materials science, due to its own structural properties, it can be used to prepare materials with specific optical and electrical properties.

[2,2 '-Biquinoline] -4,4' -dicarboxylic acid, which has a wide range of uses. In the field of chemical synthesis, it often acts as a ligand, complexes with metal ions, and then generates metal complexes with unique structures and specific properties. These complexes exhibit excellent activity in catalytic reactions, can efficiently catalyze many organic reactions, improve the reaction rate and yield, just like the miraculous additives used in ancient alchemy, accelerating the wonderful process of dansha conversion into mercury.
In the field of materials science, [2,2 '-biquinoline] -4,4' -dicarboxylic acid can participate in the preparation of functional materials. By specific means, it is integrated into the material structure to give the material unique optical and electrical properties. For example, it can produce luminescent materials that have a keen response to specific wavelengths of light, similar to ancient spiritual objects that can emit strange light with different celestial phenomena. It has great potential in the field of optoelectronic devices and can be used to manufacture Light Emitting Diodes, sensors, etc.
In the field of biomedicine, because of its certain biocompatibility and unique chemical structure, it can be used to design and synthesize biological probes. This probe can accurately identify specific molecules or cells in living organisms, just like the magic silver needle in the hands of ancient gods, accurately exploring the source of disease, and assisting in early diagnosis and treatment monitoring of diseases. And in drug development, it may serve as a lead compound template, and through structural modification and optimization, create new drugs with better efficacy and fewer side effects.

[2,2 '-Biquinoline] -4,4' -dicarboxylic acid, an organic compound. Its physical properties are as follows:
In terms of color state, it often appears as a crystalline solid, with a pure appearance and a specific crystal structure. This morphology is determined by the interaction and arrangement of molecules. Due to the conjugated system of molecular structure and the characteristics of functional groups, the solid color is mostly white to light yellow, and this color difference may vary due to purity and crystallization conditions.
In terms of solubility, its solubility in water is limited. Although the carboxyl group in its molecule can form a hydrogen bond with water, the part of the quinoline is a hydrophobic structure, resulting in the overall solubility in water is not high. However, in polar organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), the solubility is better. This is because these organic solvents can form stronger intermolecular forces with the compound, overcoming the hydrophobicity of its molecules, and assisting its dispersion and dissolution.
Melting point is also an important physical property. Experiments have determined that its melting point is in a specific temperature range. At this temperature, solid substances absorb energy, molecular vibration intensifies, and the lattice structure is destroyed, and then it transforms into a liquid state. Accurate melting point data is of great significance for the identification of purity and quality. The higher the purity, the closer the melting point is to the theoretical value, and the narrower the melting range.
In addition, the compound has certain stability and can maintain its own structure and properties at room temperature and pressure. However, under extreme conditions such as high temperature and strong acid and base, the molecular structure may change, such as the reaction of carboxylic groups with acid and base, which affects its physical and chemical properties.
In summary, the physical properties of [2,2 '-biquinoline] -4,4' -dicarboxylic acid have a profound impact on its application in chemical synthesis, materials science and other fields. Researchers need to rationally design experiments and application plans according to its characteristics.

% 5B2% 2C2% 27 - biquinoline% 5D - 4% 2C4% 27 - dicarboxylic acid is [2,2 '-biquinoline] -4,4' -dicarboxylic acid. There are many ways to synthesize this compound. The following are the common ways:
First, use 2-methylquinoline as the starting material. First, 2-methylquinoline is oxidized under specific conditions by an oxidant. For example, using strong oxidants such as potassium permanganate or potassium dichromate can convert methyl into carboxyl groups to obtain 4-carboxyl-2-methylquinoline. Subsequently, by coupling reaction, such as Ullmann reaction, two molecules of 4-carboxyl-2-methylquinoline are coupled under the catalytic action of copper powder and base, so as to construct a 2,2 '-biquinoline structure, and finally obtain [2,2' -biquinoline] -4,4 '-dicarboxylic acid. This process condition is quite critical, and the oxidation step needs to pay attention to control the reaction temperature and the amount of oxidant to prevent excessive oxidation; the coupling reaction requires very strict requirements on the catalyst and reaction solvent.
Second, quinoline-2-formaldehyde is used as the starting material. Quinoline-2-formaldehyde is first condensed by Knoevenagel, and reacted with active methylene compounds such as malonic acid under the catalysis of weak bases such as pyridine to obtain 2- (2-quinolinyl) acrylic intermediates. After that, the intermediates are oxidized by hydrogen peroxide to achieve double bond cleavage and carboxylation, and then [2,2 '-biquinoline] -4,4' -dicarboxylic acid is synthesized. In this route, the Knoevenagel condensation reaction needs to control the appropriate pH and reaction time, and the oxidation step should pay attention to the effect of reaction conditions on product selectivity.
Third, the cyclization reaction using metal catalysis. [2,2 '-biquinoline] -4,4' -dicarboxylic acid can also be prepared from suitable derivatives of o-halobenzonitrile in the presence of transition metal catalysts such as palladium and nickel, in combination with nitrogen-containing ligands and bases, through intramolecular cyclization and subsequent hydrolysis and oxidation. In this method, the selection of metal catalysts and the design of ligands play a decisive role in the activity and selectivity of the reaction, and the precise regulation of the reaction conditions at each step is related to the purity and yield of the product.

[2,2 '-Biquinoline] -4,4' -dicarboxylic acid, which is useful in many fields. In the field of materials science, due to its unique structure and properties, it can be used as a key building block for the construction of exquisite materials. With its ingenious complexation with metal ions, it can create metal-organic framework materials (MOFs) with outstanding performance. Such materials shine in the field of gas adsorption and separation, and can efficiently capture specific gases, such as carbon dioxide, which is of great significance for environmental protection and carbon reduction. In the field of catalysis, [2,2 '-biquinoline] -4,4' -dicarboxylic acid is often used as a ligand, in coordination with metal catalysts, greatly improve the efficiency and selectivity of catalytic reactions, and many organic synthesis reactions can be precisely advanced.
In the field of biomedicine, it also has a good performance. It can be cleverly modified as a fluorescent probe, which can achieve accurate detection and imaging of substances in living organisms by virtue of its keen response to specific biomolecules, helping medical research to penetrate into the microscopic level and gain insight into the mysteries of life. In the field of chemical sensing, with the specific recognition ability of specific analytes, a highly sensitive sensing system is constructed to quickly and accurately detect environmental pollutants or biomarkers, providing powerful means for environmental monitoring and disease diagnosis. All of this shows that [2,2 '-biquinoline] -4,4' -dicarboxylic acid is an indispensable and important substance in today's scientific research and practical applications.